Novel perspectives on the function of AB5 toxin B subunits

AB5 毒素 B 亚基功能的新视角

• 批准号: nhmrc : 1084050
• 负责人: Dr Travis Beddoe
• 金额: $ 69.47万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-perspectives-function-b-subunits/518976
• 关键词: Novel; perspectives; function; AB5; toxin

AB5 toxins are important virulence factors of pathogenic bacteria. They comprise pentameric B subunits that bind to target cell surfaces and catalytic A subunits that damage host cell functions. This proposal examines a new paradigm wherein the B subunits are significant contributors to cell damage. We will characterize the cytopathic properties of diverse B subunits, particularly those of emerging toxins. This will provide novel insights into pathogenesis and inform development of therapeutics.

AB5毒素是致病菌的重要毒力因子。它们包括结合靶细胞表面的五聚体B亚基和破坏宿主细胞功能的催化性A亚基。该提议研究了一种新的范例，其中B亚基是细胞损伤的重要贡献者。我们将描述不同B亚基的致细胞病变特性，特别是那些新出现的毒素。这将为发病机制提供新的见解，并为治疗方法的发展提供信息。