A functional and structural approach to understanding Leptospiral host-pathogen interactions

了解钩端螺旋体宿主-病原体相互作用的功能和结构方法

• 批准号: nhmrc : 491010
• 负责人: Dr Travis Beddoe
• 金额: $ 33.61万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-structural-approach-pathogen-interactions/99837
• 关键词: functional; structural; approach; understanding; Leptospiral

Leptospirosis is a zoonosis of worldwide distribution caused by infection with pathogenic Leptospira. Infection occurs due to contact with water contaminated by urine of domestic animals. It occurs infrequently in Australia, but recent local surveillance data indicate hospitalisation rate of 56% with an average duration of 5.3 days. Through the combined approach of structural biology and functional microbiology we hope to understand how leptospira interacts with the human host.

钩端螺旋体病是由致病性钩端螺旋体感染引起的一种世界性分布的人畜共患病。感染是由于接触被家畜尿液污染的水。它在澳大利亚很少发生，但最近的当地监测数据显示，住院率为56%，平均住院时间为5.3天。通过结构生物学和功能微生物学的结合，我们希望了解钩端螺旋体如何与人类宿主相互作用。