Structural characterization of novel AB5 cytotoxin - SubAB

新型 AB5 细胞毒素 - SubAB 的结构表征

• 批准号: nhmrc : 491011
• 负责人: Dr Travis Beddoe
• 金额: $ 29.67万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-characterization-novel-cytotoxin-subab/81507
• 关键词: Structural; characterization; novel; AB5; cytotoxin

AB5 toxins are virulence factors from a range of pathogenic bacteria, including Shiga toxigenic E. coli (STEC), S. dysenteriae, V. cholerae, and B. pertussis. AB5 toxins comprise a catalytic A subunit that disrupts distinct essential cellular processes within the cell and a receptor binding, pentameric B subunit that enables the toxin to target certain cell types. We are structural characterizing a novel AB5 toxin that targets an essential component of the cellular machinery.

AB5毒素是一系列致病菌的毒力因子，包括志贺产毒大肠杆菌(STEC)、痢疾杆菌、霍乱弧菌和百日咳杆菌。AB5毒素包括一个催化A亚单位，它扰乱细胞内不同的基本细胞过程，以及一个受体结合的五聚体B亚单位，使毒素能够靶向某些细胞类型。我们正在对一种新型的AB5毒素进行结构表征，该毒素针对细胞机械的一个基本组件。