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Modulators of RPS14 with broad antiviral activity

Modulators of RPS14 with broad antiviral activity
具有广泛抗病毒活性的 RPS14 调节剂
批准号：
10916045
负责人：
Juan Marugan
金额：
$24.08万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916045
关键词：
AdenovirusesAutomobile DrivingBasic ScienceBindingBiological AssayHealthHumanHuman GenomeLeadNational Center for Advancing Translational SciencesRare DiseasesReagentReportingResearchTestingTranslationsViral PhysiologyWorkbiophysical techniquescandidate identificationdesigndrug candidateimprovednovelpharmacologicprogramssmall moleculetoolvirtual screening

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英文摘要
This collaborative team aims to build on previous research by uncovering novel modulators of RPS14. During the reporting period, the collaborative team worked to identify candidate RPS14 binders using a virtual screening approach. Molecules were tested for RPS14 binding using biophysical approaches and activity was assessed in adenovirus replication assays. At present, the team is pursuing structural studies and designing reagents to further characterize hits and confirm on-target activity, with a view to nominating a lead small molecule modulator of RPS14.
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