Modulators of RPS14 with broad antiviral activity

具有广泛抗病毒活性的 RPS14 调节剂

• 批准号: 10916045
• 负责人: Juan Marugan
• 金额: $ 24.08万
• 依托单位: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10916045
• 关键词: Adenoviruses; Automobile Driving; Basic Science; Binding; Biological Assay; Health; Human; Human Genome; Lead; National Center for Advancing Translational Sciences; Rare Diseases; Reagent; Reporting; Research; Testing; Translations; Viral Physiology; Work; biophysical techniques; candidate identification; design; drug candidate; improved; novel; pharmacologic; programs; small molecule; tool; virtual screening

This collaborative team aims to build on previous research by uncovering novel modulators of RPS14. During the reporting period, the collaborative team worked to identify candidate RPS14 binders using a virtual screening approach. Molecules were tested for RPS14 binding using biophysical approaches and activity was assessed in adenovirus replication assays. At present, the team is pursuing structural studies and designing reagents to further characterize hits and confirm on-target activity, with a view to nominating a lead small molecule modulator of RPS14.

该合作团队旨在通过发现RPS14的新型调制器来建立先前的研究。在报告期间，合作团队使用虚拟筛选方法确定候选RPS14粘合剂。利用生物物理方法检测分子与RPS14的结合，并通过腺病毒复制试验评估其活性。目前，该团队正在进行结构研究和设计试剂，以进一步表征命中并确认靶活性，以期提名RPS14的主要小分子调节剂。