课题基金 / 基金详情

Modulators of RPS14 with broad antiviral activity

Modulators of RPS14 with broad antiviral activity
具有广泛抗病毒活性的 RPS14 调节剂
批准号：
10916045
负责人：
Juan Marugan
金额：
$24.08万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916045
关键词：
AdenovirusesAutomobile DrivingBasic ScienceBindingBiological AssayHealthHumanHuman GenomeLeadNational Center for Advancing Translational SciencesRare DiseasesReagentReportingResearchTestingTranslationsViral PhysiologyWorkbiophysical techniquescandidate identificationdesigndrug candidateimprovednovelpharmacologicprogramssmall moleculetoolvirtual screening

项目摘要

项目成果

Juan Marugan的其他基金

相似基金

相关文献

中文摘要
翻译
该合作团队旨在通过发现RPS14的新型调制器来建立先前的研究。在报告期间，合作团队使用虚拟筛选方法确定候选RPS14粘合剂。利用生物物理方法检测分子与RPS14的结合，并通过腺病毒复制试验评估其活性。目前，该团队正在进行结构研究和设计试剂，以进一步表征命中并确认靶活性，以期提名RPS14的主要小分子调节剂。
英文摘要
This collaborative team aims to build on previous research by uncovering novel modulators of RPS14. During the reporting period, the collaborative team worked to identify candidate RPS14 binders using a virtual screening approach. Molecules were tested for RPS14 binding using biophysical approaches and activity was assessed in adenovirus replication assays. At present, the team is pursuing structural studies and designing reagents to further characterize hits and confirm on-target activity, with a view to nominating a lead small molecule modulator of RPS14.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Small molecule agonists of the relaxin 1 receptor
Identification of Small Molecule that act on gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome
Kinetic High Throughput Screening for Agonists and Inhibitors of the TRPML1 Ion channel
HTS Assay for Identification of Compounds that Reduce PNC Prevalence
海外基金