Identification of Small Molecule that act on gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome

鉴定作用于 gsp 的小分子，gsp 是导致纤维发育不良/麦库恩-奥尔布赖特综合征的病因突变

• 批准号: 9205776
• 负责人: Juan Marugan
• 金额: $ 11.4万
• 依托单位: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9205776
• 关键词: Identification; Small; Molecule; act; gsp

During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.

在此期间，NCGC与NIH和校外研究人员建立并维持了180多项积极合作，促进了整个人类疾病范围内的药物发现工作。这些努力已经导致了100多个高通量筛选和近60个药物化学活动，为我们的合作者和一般研究界提供了丰富的出版物和有前途的小分子线索。此外，NCGC还承担了一些信息学方面的挑战，以便更好地利用现有的药物和疾病目标信息，并向公众提供易于获得的资源，进一步促进人类疾病新疗法的发展。