"Sao Paulo-Minas Gerais Center for Chagas Disease Treatment (SaMiTrop)"

“圣保罗-米纳斯吉拉斯州恰加斯病治疗中心 (SaMiTrop)”

• 批准号: 10592351
• 负责人: Ester Cerdeira Sabino
• 金额: $ 38.87万
• 依托单位: FUNDACAO FACULDADE DE MEDICINA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592351
• 关键词: Antibodies; Area; Articulation; Artificial Intelligence; Benznidazole; Biological Markers; Cardiac; Cardiomyopathies; Central America; Chagas Disease; Chronic; Clinical; Data; Data Collection; Diagnosis; Disease Marker; Enrollment; Etiology; Health system; Healthcare Systems; Heart Diseases; Imaging Techniques; Inflammation; Knowledge; Latin America; Lesion; Magnetic Resonance; Maps; Measures; Methodology; Methods; Morbidity - disease rate; Myocardial; Myocardial tissue; Natural History; Patients; Persons; Plasma; Positron-Emission Tomography; Primary Health Care; Process; Prospective cohort; Protocols documentation; Registries; Research; Research Personnel; Sampling; Surrogate Markers; Testing; Treatment Efficacy; Tropical Medicine; Trypanocidal Agents; Trypanosoma cruzi; biomarker identification; biomarker panel; biomarker validation; candidate marker; clinically relevant; cohort; diagnostic strategy; digital health; efficacy validation; follow-up; health care availability; health service use; heart imaging; implementation framework; implementation science; improved; mortality; neglect; patient-level barriers; prospective; response; success; tool

ABSTRACT Chagas disease (CD) remains one of the most neglected illnesses in the world, with estimates indicating 5.7 million infected people in Latin and Central America. Currently, there are many barriers that patients with CD have to overcome to obtain a diagnosis, adequate treatment, and appropriate follow-up. One of the main ones is the high rate of underdiagnosis and consequently of patients treated. It is estimated that less than 10% of patients are diagnosed and that less than 1% are treated. Furthermore, to date, there is no "reliable" method that allows measuring therapeutic efficacy. During the last 15 years, researchers from the São Paulo-Minas Gerais Tropical Medicine Research Center (SaMi-Trop) have developed numerous projects that have evidenced the high number of patients in an endemic area in the north of the State of Minas Gerais, in addition to providing valuable information on the natural history of CD, the rate of progression to cardiomyopathy and its relationship with antibody levels. A great key to the success of such initiatives has been their strategic articulation with primary health care, which has made it possible to have large cohorts of patients accompanied for more than 10 years. Therefore, it is intended in this project to apply all this knowledge and articulation to identify methodologies and tools that allow overcoming existing barriers. The results obtained will make it possible to increase the number of diagnosed patients to whom treatment will be offered and identify strategies and biomarkers that make it possible to improve patient follow-up and help evaluate new treatment candidates.

摘要 恰加斯病（CD）仍然是世界上最被忽视的疾病之一，估计有5.7 在拉丁美洲和中美洲有100万感染者。目前，有许多障碍， 必须克服这些障碍才能获得诊断、适当的治疗和适当的随访。其中一个主要的原因是 诊断不足率高，因此患者治疗不足。据估计，不到10%的患者 只有不到1%的人得到了治疗。此外，到目前为止，还没有一种“可靠”的方法， 测量治疗效果。在过去的15年里，来自圣保罗-米纳斯吉拉斯热带地区的研究人员 医学研究中心（SaMi-Trop）已经开发了许多项目，证明了大量的 在米纳斯吉拉斯州北部的一个地方病流行区， 关于CD自然史、进展为心肌病的速度及其与 抗体水平。这些举措取得成功的一个重要关键是它们与主要的 医疗保健，这使得有可能有大量的病人陪同超过10年。 因此，本项目的目的是应用所有这些知识和衔接来确定方法， 克服现有障碍的工具。所取得的成果将有可能增加 的诊断患者将提供治疗，并确定战略和生物标志物，使其 可以改善患者随访并帮助评估新的治疗候选者。