Spatiotemporal Organization of the Inferior Frontal Gyrus During Speech Production - Resubmission - 1

言语产生过程中额下回的时空组织 - 重新提交 - 1

基本信息

  • 批准号:
    10591409
  • 负责人:
  • 金额:
    $ 56.45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-05-15 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

Project Summary Speech is a uniquely human trait that is central to our everyday lives, but the mechanisms that enable retrieval and formation of articulatory sequences remain elusive. Several lines of evidence suggest that the left inferior frontal gyrus (IFG), or Broca’s region, is active prior to articulation per se and critically supports articulatory planning. However, it remains unclear how different anatomical parcellations of IFG support retrieval of semantic information and articulatory planning. To investigate this issue, we will leverage resources at NYU, assembling clinicians and researchers with complementary expertise to reexamine the role of the IFG in speech. We propose working in a cohort of neurosurgical patients who provide a rare and unique opportunity to collect direct cortical recordings and perturbations during speech production. Specifically, we will address the following questions: (1) what is the time constant of neural responses across IFG in relation to speech production, (2) what is the functional specificity of IFG regions, pars opercularis and pars triangularis, and (3) what are the functional boundaries Broca’s territory across the left and right frontal cortices. To gain traction on these issues, we have developed a battery of speech production tasks that is designed to mirror clinical electrical stimulation mapping and provides a within subject functional and causal comparison. We will use standard and high density electrocorticography (ECoG) to measure responses with high temporal precision within IFG. To determine causality, we will manipulate cortical activity using direct cortical stimulation and examine changes in behavior, timing of speech deficits and comparing with ECoG functional responses. The outcome of this study will greatly advance our understanding of the neurophysiologic mechanisms underlying speech production with a long-term goal of addressing a range of speech disorders and improving current language mapping techniques.
项目总结

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Neural correlates of sign language production revealed by electrocorticography.
  • DOI:
    10.1212/wnl.0000000000010639
  • 发表时间:
    2020-11-24
  • 期刊:
  • 影响因子:
    9.9
  • 作者:
    Shum J;Fanda L;Dugan P;Doyle WK;Devinsky O;Flinker A
  • 通讯作者:
    Flinker A
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Adeen Flinker其他文献

Adeen Flinker的其他文献

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{{ truncateString('Adeen Flinker', 18)}}的其他基金

Characterizing the temporal processing of speech in the human auditory cortex
表征人类听觉皮层中语音的时间处理
  • 批准号:
    10211535
  • 财政年份:
    2021
  • 资助金额:
    $ 56.45万
  • 项目类别:
Characterizing the temporal processing of speech in the human auditory cortex
表征人类听觉皮层中语音的时间处理
  • 批准号:
    10448483
  • 财政年份:
    2021
  • 资助金额:
    $ 56.45万
  • 项目类别:
Characterizing the temporal processing of speech in the human auditory cortex
表征人类听觉皮层中语音的时间处理
  • 批准号:
    10626815
  • 财政年份:
    2021
  • 资助金额:
    $ 56.45万
  • 项目类别:
Spatiotemporal organization of the inferior frontal gyrus during speech production - Resubmission - 1
言语产生过程中额下回的时空组织 - 重新提交 - 1
  • 批准号:
    10369007
  • 财政年份:
    2019
  • 资助金额:
    $ 56.45万
  • 项目类别:
Hemispheric asymmetry in auditory processing - spectral and temporal modulations
听觉处理中的半球不对称 - 频谱和时间调制
  • 批准号:
    8703518
  • 财政年份:
    2012
  • 资助金额:
    $ 56.45万
  • 项目类别:
Hemispheric asymmetry in auditory processing - spectral and temporal modulations
听觉处理中的半球不对称 - 频谱和时间调制
  • 批准号:
    8457327
  • 财政年份:
    2012
  • 资助金额:
    $ 56.45万
  • 项目类别:
Hemispheric asymmetry in auditory processing - spectral and temporal modulations
听觉处理中的半球不对称 - 频谱和时间调制
  • 批准号:
    8543455
  • 财政年份:
    2012
  • 资助金额:
    $ 56.45万
  • 项目类别:
Electrocorticographic Analysis of Phonological and Lexical Processing
语音和词汇处理的皮质电图分析
  • 批准号:
    8061270
  • 财政年份:
    2011
  • 资助金额:
    $ 56.45万
  • 项目类别:

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