权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Spatiotemporal Organization of the Inferior Frontal Gyrus During Speech Production - Resubmission - 1

言语产生过程中额下回的时空组织 - 重新提交 - 1

基本信息

批准号：
10591409
负责人：
Adeen Flinker
金额：
$ 56.45万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10591409
关键词：
Address Anatomy Anterior Aphasia Articulation Articulators Behavior Bilateral Biological Assay Broca&apos s area Clinical Data Electric Stimulation Electrocorticogram Electrodes Etiology Goals Human Impairment Inferior frontal gyrus Knowledge Language Left Lesion Maps Measurement Measures Medical center Middle Inferior Frontal Convolution Mutism Names New York Operative Surgical Procedures Outcome Study Output Patients Physical shape Probability Production Research Personnel Resolution Resources Retrieval Role Sampling Semantics Site Spatial Distribution Specificity Speech Speech Disorders Surface Techniques Testing Time Traction Universities cognitive task cohort density design frontal lobe improved neural neuroimaging neurophysiology neurosurgery neurotransmission novel therapeutic intervention prevent response segregation semantic processing simulation spatiotemporal trait

项目摘要

Project Summary Speech is a uniquely human trait that is central to our everyday lives, but the mechanisms that enable retrieval and formation of articulatory sequences remain elusive. Several lines of evidence suggest that the left inferior frontal gyrus (IFG), or Broca’s region, is active prior to articulation per se and critically supports articulatory planning. However, it remains unclear how different anatomical parcellations of IFG support retrieval of semantic information and articulatory planning. To investigate this issue, we will leverage resources at NYU, assembling clinicians and researchers with complementary expertise to reexamine the role of the IFG in speech. We propose working in a cohort of neurosurgical patients who provide a rare and unique opportunity to collect direct cortical recordings and perturbations during speech production. Specifically, we will address the following questions: (1) what is the time constant of neural responses across IFG in relation to speech production, (2) what is the functional specificity of IFG regions, pars opercularis and pars triangularis, and (3) what are the functional boundaries Broca’s territory across the left and right frontal cortices. To gain traction on these issues, we have developed a battery of speech production tasks that is designed to mirror clinical electrical stimulation mapping and provides a within subject functional and causal comparison. We will use standard and high density electrocorticography (ECoG) to measure responses with high temporal precision within IFG. To determine causality, we will manipulate cortical activity using direct cortical stimulation and examine changes in behavior, timing of speech deficits and comparing with ECoG functional responses. The outcome of this study will greatly advance our understanding of the neurophysiologic mechanisms underlying speech production with a long-term goal of addressing a range of speech disorders and improving current language mapping techniques.

项目总结