Developmental prosopagnosia subtypes: validation, neural mechanisms, and differential approaches to treatment

发育性面盲症亚型：验证、神经机制和不同的治疗方法

• 批准号: 10565937
• 负责人: Joseph Michael DeGutis
• 金额: $ 40.52万
• 依托单位: BOSTON VA RESEARCH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10565937
• 关键词: Affect; Alzheimer' s Disease; Anger; Area; Behavior; Behavioral; Cognitive; Collection; Computers; DSM-V; Data; Depressed mood; Development; Diffusion Magnetic Resonance Imaging; Disease; Electroencephalography; Emotions; Employment; Event-Related Potentials; Eye; Face; Face Processing; Fright; Functional Magnetic Resonance Imaging; Goals; Grouping; Heterogeneity; Impairment; Individual; Learning; Longevity; Longitudinal Studies; Measures; Memory; Memory impairment; Mission; National Eye Institute; Online Systems; Oral cavity; Patient Self-Report; Perception; Pilot Projects; Population; Population Decreases; Research; Sample Size; Sampling; Schizophrenia; Subgroup; Testing; Training; Training Programs; Validation; Vision; Vision Disorders; Visual; Waiting Lists; autism spectrum disorder; behavior test; cognitive training; comparison control; computerized; developmental prosopagnosia; face perception; improved; individualized medicine; neural; neuromechanism; novel; receptive field; recruit; response; sample fixation; social anxiety; treatment response; trend; white matter

The goal of this proposal is to better characterize the cognitive and neural basis of face perception heterogeneity in developmental prosopagnosia (DP) and to test whether potential perceptual subtypes are better suited for one type of cognitive training program vs. another. This is relevant to the National Eye Institute's mission to better treat visual disorders and understand mechanisms of visual function. Our pilot results (N=45 DPs) provide preliminary evidence that there are perceptually-impaired (PI-DPs) and perceptually-unimpaired (PU-DPs) DP subgroups that may be mechanistically distinct. We find that PI-DPs have deficient eye processing, reduced holistic processing abilities, reduced N170 response to eye contrast- reversed faces, and a trend towards decreased white matter integrity in the occipital face area, a face-selective region involved in face parts processing. We also find that PI-DPs, compared to PU-DPs, show a greater treatment response to our computerized face perception training program. The goals of the current proposal are to build on these pilot results to further test and validate the PI-DP vs. PU-DP subgroup distinction, to better understand the neural mechanisms underlying perceptual heterogeneity in DPs, and to examine treatment implications of potential subgroups. In particular, our aims for this proposal are to: 1) Collect a large sample of web-based and in-lab DPs (N=280) and controls (N=140) and replicate our pilot findings showing eye processing and holistic processing deficits in PI-DPs. We will also perform latent profile analysis to determine if DPs naturally form PI-DP vs. PU-DP subgroups or rather represent a continuum of face perception deficits. 2) Characterize the neural mechanisms of DP face perception heterogeneity using functional fMRI, EEG, and diffusion tensor imaging in 80 DPs and 40 controls. To test better understand the neural underpinnings of DPs' reduced eye region sensitivity and reduced holistic processing, we seek examine the N170 event-related potential response to isolated eyes vs. mouths as well as face inversion and for fMRI, population receptive fields of face-selective regions as well as responses to isolated mouths and eyes. We will also examine whether PI-DPs vs. PU-DPs have white matter integrity differences in face-selective white matter regions. 3) Determine whether PI-DPs vs. PU-DPs have differential responses to face perception training, face memory training, or face perception+face memory training programs. This will involve a longitudinal study of 120 DPs being assigned to either a waitlist control condition or 6 weeks of one of the three cognitive training programs. Before and after training/waiting, we will assess DPs on a validated battery of face perception and recognition tests as well as self-reported face recognition. To measure the longevity of potential training effects, DPs will also repeat assessments after a 6-week no-contact period.

这个提议的目的是更好地描述面部感知的认知和神经基础 异质性的发展性面容失认症（DP），并测试是否潜在的知觉亚型， 更适合一种类型的认知训练计划而不是另一种。这与国民眼有关 研究所的使命是更好地治疗视觉障碍和了解视觉功能的机制。我们的飞行员 结果（N=45 DP）提供了初步证据，表明存在感知受损（PI-DP）， 感知未受损（PU-DP）DP亚组，其可能在机制上不同。我们发现PI-DP 眼睛处理能力不足，整体处理能力降低，对眼睛对比度的N170反应降低， 颠倒的面孔，以及枕骨面部区域白色物质完整性降低的趋势， 涉及面零件加工的区域。我们还发现，与PU-DP相比，PI-DP显示出更大的 治疗反应我们的计算机化的脸知觉训练计划。本提案的目标 将在这些试点结果的基础上进一步测试和验证PI-DP与PU-DP亚组的区别， 更好地理解DP中感知异质性的神经机制，并检查 潜在亚组的治疗影响。具体而言，我们提出这项建议的目的是：1）收集大量 基于网络和实验室DP（N=280）和对照组（N=140）的样本，并复制我们的试点结果，显示 眼加工和整体加工缺陷。我们还将进行潜在的个人资料分析， 确定DP是否自然形成PI-DP与PU-DP子组，或者更确切地说，是否代表面部的连续体 知觉缺陷2)描述DP人脸感知异质性的神经机制， 在80名DP和40名对照中进行功能性fMRI、EEG和弥散张量成像。为了更好地理解测试， DP的眼区敏感性降低和整体处理能力降低的神经基础，我们试图检查 N170事件相关电位对离体眼与嘴的反应以及面部倒置和功能磁共振成像， 面部选择性区域的群体感受野以及对孤立的嘴和眼睛的反应。我们将 还检查PI-DP与PU-DP在面部选择性白色物质中是否具有白色物质完整性差异 地区3)确定PI-DP与PU-DP是否对面部感知训练、面部 记忆训练，或面部感知+面部记忆训练计划。这将涉及一项纵向研究， 120名DP被分配到候补名单控制条件或6周的三种认知训练之一 程序.在训练/等待之前和之后，我们将评估DP对面部感知的验证电池， 识别测试以及自我报告的面部识别。为了测量潜在训练的寿命 在为期6周的无接触期后，DP也将重复评估。