Characterizing training-related neuroplasticity in developmental prosopagnosia

表征发育性面盲症中与训练相关的神经可塑性

• 批准号: 9008389
• 负责人: Joseph Michael DeGutis
• 金额: $ 39.55万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9008389
• 关键词: Address; Affect; Anterior; Area; Behavior assessment; Cognition Disorders; Cognitive; Computers; Control Groups; Data Analyses; Development; Diffusion Magnetic Resonance Imaging; Discrimination; Disease; E-learning; Effectiveness; Employment Opportunities; Event-Related Potentials; Eye; Face; Face Processing; Functional Magnetic Resonance Imaging; Goals; Home environment; Individual; Intervention; Laboratories; Lead; Learning; Life; Longevity; MRI Scans; Measures; Memory; Mission; Monitor; National Eye Institute; Neuronal Plasticity; Oral cavity; Participant; Patient Self-Report; Performance; Persons; Population; Process; Published Comment; Randomized; Recruitment Activity; Reporting; Resolution; Rest; Running; Scanning; Social Functioning; Testing; Time; Training; Training Programs; Variant; Vision; Vision Disorders; Work; active control; base; blind; cognitive training; daily functioning; developmental prosopagnosia; effective therapy; face perception; functional outcomes; fusiform face area; improved; improved outcome; laptop; programs; public health relevance; relating to nervous system; response; screening; social; success; treatment program; white matter; white matter change

 DESCRIPTION (provided by applicant): The long-term goal of this proposal is to develop an effective treatment for developmental prosopagnosia and to understand the mechanisms of treatment-related improvements. This is relevant to the National Eye Institute's mission to better treat visual disorders and understand mechanisms of visual function. The particular goal of this proposal is to build on our previous successes at improving face processing in developmental prosopagnosics (DPs) using cognitive training targeting holistic face processing. Our specific aims for this proposal are to: 1) Determine whether an improved, longer version of the holistic face training program is more effective at improving face processing and daily functioning in developmental prosopagnosics (DPs) than active control training; 2) To use functional MRI to characterize how core and extended face processing regions change after holistic face training compared to active control training; and 3) To characterize how event-related potential (ERP) signatures of face processing change after holistic face training compared to active control training. As an exploratory aim, we also seek to determine if face-selective white matter tracts in ventral occipito-temporal regions change after holistic face training compared to active control training. To achieve these aims, we propose to run a triple-blind (assessor, participant, and data analysis is blind to treatment), randomized longitudinal treatment study with 50 DPs. We propose to have 25 DPs complete 6 weeks of holistic face training and 25 complete 6 weeks of a matched active control training that uses the same faces. After screening, DPs will perform baseline cognitive and functional assessments as well as MRI scans (including fMRI and DTI) and ERP recording. Next, DPs will be randomized to either holistic face training or active control training and will train on a laptop computer at home or in the laboratory for 30 sessions (36 mins/session) over 6 weeks. During this time, a cognitive training coach will closely monitor their progress. Within one week of intervention completion, DPs will repeat the behavioral assessments, MRI scans, and ERP recording. To measure the longevity of training effects, DPs will also repeat all assessments after a 6-week no-contact period.

 描述（由申请人提供）：本提案的长期目标是开发一种有效治疗发育性面容失认症的方法，并了解治疗相关改善的机制。这与国家眼科研究所的使命有关，即更好地治疗视觉障碍和了解视觉功能的机制。该提案的具体目标是在我们之前成功改善发育面容失认学（DP）中的面部处理的基础上，使用针对整体面部处理的认知训练。我们提出这项建议的具体目的是：1）确定一个改进的，更长版本的整体面部训练计划是否比主动控制训练更有效地改善面部加工和日常功能; 2）使用功能性MRI来表征与主动控制训练相比，整体面部训练后核心和扩展面部加工区域的变化;（3）研究整体面孔训练与主动控制训练相比，面孔加工的事件相关电位（ERP）特征的变化。作为一个探索性的目标，我们还试图确定面部选择性白色物质是否会在大脑中收缩， 与主动控制训练相比，整体面部训练后腹侧枕颞区发生变化。为了实现这些目标，我们建议进行一项三盲（评估者、受试者和数据分析对治疗设盲）、随机纵向治疗研究（50名DP）。我们建议让25名DP完成6周的整体面部训练，25名完成6周的匹配主动控制训练，使用相同的面部。筛选后，DP将进行基线认知和功能评估以及MRI扫描（包括fMRI和DTI）和ERP记录。接下来，DP将随机接受整体面部训练或主动控制训练，并将在家中或实验室的笔记本电脑上进行为期6周的30次训练（36分钟/次）。在此期间，认知训练教练将密切监测他们的 中求进工作总在干预完成后的一周内，DP将重复行为评估，MRI扫描和ERP记录。为了测量培训效果的持久性，DP还将在6周的无接触期后重复所有评估。