Long Lasting Organic Semiochemical Formulation to Effectively Manage Blood Sucking Diptera.

持久的有机化学制剂可有效控制吸血双翅目。

• 批准号: 10565865
• 负责人: Agenor Mafra-Neto
• 金额: $ 100万
• 依托单位: ISCA TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-12 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10565865
• 关键词: Adoption; Adult; Aedes; Air; Anopheles Genus; Area; Bacillus thuringiensis; Bacteria; Bacterial Artificial Chromosomes; Beds; Behavior; Biological; Blood; Blood-Borne Pathogens; Brazil; Breeding; Chemicals; Collection; Consumption; Control Groups; Culex (Genus); Culicidae; Data; Dengue; Diptera; Dryness; Ensure; Environment; Exposure to; Female; Floods; Food; Formulation; Fostering; Friends; Grant; Habitats; Home; Human Bites; Infection; Ingestion; Insecticides; International; Intervention; Invaded; Juvenile Hormones; Larva; Left; Life; Malaria; Marketing; Measures; Methoprene; Mosquito Control; Mosquito-borne infectious disease; Names; Nature; Organophosphates; Oviposition; Partner in relationship; Penetration; Persons; Pest Control; Phase; Pilot Projects; Population; Predisposition; Process; Rain; Readiness; Regulation; Research; Residual state; Resistance; Resistance development; Risk; Risk Reduction; Running; Safety; Sales; Sedimentation process; Semiochemicals; Site; Source; Stimulant; Surface; Tanzania; Technology; Temephos; Toxin; United States National Institutes of Health; Variant; Vectorial capacity; Water; West Nile virus; ZIKA; commercialization; controlled release; design; disease transmission; efficacy trial; egg; feeding; larval control; malaria mosquito; malaria transmission; mortality; novel; outbreak control; preference; prevent; programs; pyrethroid; research and development; success; sucking; transmission process; vector; vector management strategies; vector mosquito

Project Summary: SPLAT BAC Plus is a unique controlled-release larvicide designed to suppress populations of multiple species of mosquitoes, such as those that transmit malaria, dengue, and West Nile virus (WNV). This CRP proposal seeks to establish SPLAT BAC Plus as an effective, economically viable control strategy for use in integrated vector management (IVM) programs and for control of nuisance mosquitoes around the globe. SPLAT BAC Plus has several advantages over previous larvicides: 1) It contains a combination of larvicidal agents with different modes of action: Bacillus thuringiensis israelensis (Bti), B. sphaericus (Bsp) [recently renamed Lysinibacillus sphaericus]—two bacteria that destroy the gut of mosquitoes that ingest them—and an insect growth regulator (IGR), such as methoprene or pyriproxyfen, that prevents larvae from developing into adults. This combination drastically reduces the risk of resistance compared to single-action larvicides. While there are products on the market combining Bti and Bsp, the inclusion of an IGR in SPLAT BAC Plus will further inhibit the development of resistance and greatly extend the field life of the larvicide. 2) SPLAT BAC Plus includes components that promote larval attraction and feeding on the formulation—intensifying their exposure to the Bti, Bsp, and IGR contained within it—and oviposition attractants (attractants for egg-laying females). As point sources of SPLAT BAC Plus float at the surface of treated water, these attractants are released into the air, enticing female mosquitoes to lay their eggs preferentially at that site. 3) SPLAT BAC Plus can be applied to potential larval habitats under dry conditions ahead of rainfall, a major advantage over most larvicides, which must be applied shortly after these sites fill with water to catch mosquito larvae at a susceptible stage. 4) Following application, SPLAT BAC Plus cures and becomes rainfast, becoming activated when the surfaces are submerged for a few days, detaching and floating to the water's surface and releasing its attractants. After this point, SPLAT BAC Plus remains buoyant and effective for up to 5 months, considerably longer than the 1–2 week-field life associated with older Bti/Bsp larvicides. 5) SPLAT BAC Plus contains environmentally safe larvicides and semiochemical attractants incorporated in an inert matrix composed of food-safe ingredients. To achieve global commercialization of SPLAT BAC Plus, ISCA Technologies intends to pursue the following Specific Aims: 1) Obtain the required regulatory approvals to begin sales of SPLAT BAC Plus in the US and begin penetration of target international markets (e.g., Brazil, Tanzania); 2) Foster consumer support and buy-in via demonstration trials of SPLAT BAC Plus with targeted distributors of mosquito control products, pest control operators (PCOs), and mosquito control districts; and 3) Utilize SPLAT BAC Plus to launch a more diversified product line of mosquito control technologies, designed to conform to the different needs of various mosquito control groups and consumers, such as varying target species, environmental and safety concerns, and difficulties with resistance to different control agents.

项目概要： SPLAT BAC Plus是一种独特的控制释放杀幼虫剂，旨在抑制多个物种的种群。 蚊子，如传播疟疾、登革热和西尼罗河病毒（WNV）的蚊子。该CRP提案旨在 建立SPLAT BAC Plus作为一种有效的、经济上可行的控制策略，用于综合媒介 防治（IVM）计划和控制地球仪周围的讨厌蚊子。SPLAT BAC Plus具有 与以前的杀幼虫剂相比，它具有以下几个优点：1）它含有不同模式的杀幼虫剂组合 苏云金芽孢杆菌（Bacillus thuringiensis israelensis，Bti），B.球形芽孢杆菌（Bsp）[最近改名为赖氨酸芽孢杆菌 sphaericus]--两种破坏蚊子肠道的细菌，以及一种昆虫生长调节剂 (IGR)，如烯虫酯或吡丙醚，防止幼虫发育成成虫。这种组合 与单效杀幼虫剂相比，大大降低了抗药性的风险。虽然有产品在 市场结合Bti和Bsp，在SPLAT BAC Plus中包含IGR将进一步抑制发展 并大大延长了杀幼虫剂的田间使用寿命。2)SPLAT BAC Plus包括以下组件， 促进幼虫的吸引力和对制剂的摄食-加强它们对Bti、Bsp和IGR的暴露 其中包含的-和产卵引诱剂（产卵雌性引诱剂）。作为SPLAT的点源 BAC Plus漂浮在处理过的水面上，这些引诱剂被释放到空气中，引诱雌性 蚊子会优先在那里产卵。3)SPLAT BAC Plus可用于潜在幼虫 栖息地在干燥的条件下提前降雨，一个主要的优势，大多数杀幼虫剂，必须适用 不久后，这些地点充满水，以捕捉处于易感阶段的蚊子幼虫。4)在应用之后， SPLAT BAC Plus固化并固化，当表面浸没几分钟后就会被激活 天，分离和漂浮到水面，并释放其引诱剂。在此之后，SPLAT BAC Plus 保持浮力和有效长达5个月，大大超过1-2周的现场寿命相关 使用老的Bti/Bsp杀幼虫剂。5)SPLAT BAC Plus含有环保的杀幼虫剂和化学信息素 引诱剂掺入由食品安全成分组成的惰性基质中。实现全球 SPLAT BAC Plus的商业化，ISCA技术公司打算追求以下具体目标：1） 获得所需的监管批准，以便开始在美国销售SPLAT BAC Plus，并开始渗透 瞄准国际市场（例如，巴西、坦桑尼亚）; 2）通过示范促进消费者的支持和接受 SPLAT BAC Plus与目标蚊子控制产品经销商、害虫控制运营商（PCO）进行试验， 及蚊患防治区;及3）利用SPLAT BAC Plus推出更多元化的产品系列， 灭蚊技术，以配合不同灭蚊团体的不同需要 和消费者，如不同的目标物种，环境和安全问题，以及困难， 对不同控制剂的抗性。