SUPPORT SERVICES FOR THE PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS IMPLEMENTATION SCIENCE NETWORK

通过全面护理预防和治疗的支持服务 资源受限环境实施科学中的艾滋病毒感染青少年的连续体 网络(PATC3H-IN)(UG1/UM2)计划 尤尼斯·肯尼迪·施莱弗国家儿童健康和人类发展研究所(NICHD)需要为后勤和业务协调、网站和通信管理、分析和数据管理、新出现的研究基础设施、监管和监测研究活动提供支持，以通过资源受限环境实施科学网络(PATC3H-IN)(UG1/UM2)计划预防和治疗受艾滋病毒影响的青少年的综合护理连续体。 NICHD和伙伴NIH研究所预计将于2023年在亚洲和整个撒哈拉以南非洲地区通过合作协议机制资助8个PATC3H-IN UG1奖项，用于具有高度公共卫生意义的干预措施：预防高危青少年中的新艾滋病毒感染，以及在艾滋病毒负担较高的低收入到中等收入国家的艾滋病毒携带者中识别、联系和留住艾滋病毒感染者，并长期抑制病毒。PATC3H-IN网络将在其前身PATC3H所取得的成功的基础上扩大和/或改进到新的地理环境和/或风险人群，并促进急需的实施科学(IS)研究，以预防高危青少年中新的艾滋病毒感染，并在中低收入国家(LMIC)的艾滋病毒感染者中确定、联系和保留以照顾和长期抑制艾滋病毒感染者的研究。PATC3H-IN将建立一个具有多学科专门知识的调查人员网络，专门研究针对青年的PCC和IS研究，其任务将是评估针对未感染艾滋病毒的高危青年的有前景的预防创新，以及针对感染艾滋病毒的青年的治疗和护理干预措施，这些措施已在青少年或成人人口中证明有效和/或有效，并将其转化为公共卫生实践。 PATC3H-IN的结构将由多个相互依赖的功能部分组成：(1)通过UG1赠款机制授予的五个临床研究中心(CRC)；(2)将于2024年通过UM2赠款机制授予的一个实施科学协调中心(ISCC)；以及(3)科学领导委员会(SLC)。CRC将在其8个或更多参与的临床研究绩效站点(CRP)进行临床研究和临床试验，包括实施、有效性和混合实施-有效性研究。ISCC将建立基础设施，以支持整个PATC3H-IN的研究教育和能力建设，以及为利益攸关方参与和传播PATC3H-IN的研究结果和整个PATC3H-IN的高级统计建模支持建立基础设施。ISCC还将为开展基础性研究提供基础设施，以支持临床站点的工作，包括可能的建模研究和翻译项目，以及国家调查，和/或相关政策和法律的系统收集和分析。最后，SLC将负责PATC3H-IN的管理、监督和协调，并将制定和实施网络研究议程，根据需要召集工作组，对新出现的研究项目进行优先排序，有效管理临床方案的开发，实施和完成临床试验，并确保及时发布和交流结果。

Support Services for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN) (UG1/UM2) Program The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) requires support for logistical and operational coordination, website and communication management, analytic and data management, infrastructure for emerging research, regulatory, and monitoring of research activities for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN) (UG1/UM2) Program. The NICHD and partner NIH Institutes anticipate funding 8 PATC3H-IN UG1 awards in Asia and throughout sub-Saharan Africa in 2023 through a cooperative agreement mechanism for interventions of high public health significance: The prevention of new HIV infections among adolescents at risk, and the identification of, linkage to and retention in care of, and long-term viral suppression among youth living with HIV in low-to-middle income countries with high HIV burden. The PATC3H-IN network will expand and/or improve on successes achieved by its predecessor, PATC3H, to new geographic settings and/or risk populations and stimulate much needed implementation science (IS) research in the prevention of new HIV infections among adolescents at risk and the identification of, and linkage and retention to care of and long-term viral suppression among youth living with HIV in low-to-middle income countries (LMICs). PATC3H-IN will establish a network of investigators with multidisciplinary expertise on the youth-specific PHCC and in IS research, whose mission will be to evaluate promising prevention innovations contextually and developmentally tailored for HIV uninfected at-risk youth, and treatment and care interventions for youth living with HIV which have demonstrated efficacy and/or effectiveness in adolescent or adult populations and to translate them into public health practices. The structure of PATC3H-IN will consist of multiple interdependent functional components: (1) Five Clinical Research Centers (CRC) awarded through the UG1 grant mechanism; (2) one Implementation Science Coordinating Center (ISCC) to be awarded through a UM2 grant mechanism in 2024; and (3) a Scientific Leadership Committee (SLC). The CRCs will conduct clinical research and clinical trials, including implementation, effectiveness, and hybrid implementation-effectiveness studies at their 8-or more participating Clinical Research Performance Sites (CRPS). The ISCC will establish infrastructure to support research education and capacity building across PATC3H-IN, as well as infrastructure for stakeholder engagement in and dissemination of findings from PATC3H-IN and advanced statistical modeling support across PATC3H-IN. The ISCC will also provide infrastructure for conducting foundational research to support the work of clinical sites, including possible modeling studies and translation projects, as well as national surveys, and/or systematic collection and analysis of relevant policies and laws. Lastly, the SLC will be responsible for PATC3H-IN governance, oversight, and coordination, and will develop and implement the network research agenda, convening working groups as needed, prioritizing emerging research projects, efficiently managing the development of clinical protocols, implementing and completing clinical trials, and ensuring timely publication and communication of results.