SUPPORT SERVICES FOR THE PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS IMPLEMENTATION SCIENCE NETWORK
通过全面护理连续体为资源有限环境中受艾滋病毒影响的青少年提供预防和治疗支持服务 实施科学网络
基本信息
- 批准号:10917617
- 负责人:
- 金额:$ 146.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-25 至 2024-08-24
- 项目状态:已结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAdolescentAdultAffectAfrica South of the SaharaAgeAsiaAwardBrazilCaringChildhoodClinical ProtocolsClinical ResearchClinical TrialsCollectionCommunicable DiseasesCommunicationCommunitiesComprehensive Health CareContinuity of Patient CareContractsCountryDevelopmentEducationEffectivenessEnsureEquipmentFamilyFundingGeographyGoalsGrantHIVHIV InfectionsHealthHealth systemHuman ResourcesIncidenceIncomeIndividualInformation SystemsInfrastructureInterventionLawsLeadershipMissionMonitorNational Institute of Child Health and Human DevelopmentNational Institute on Minority Health and Health DisparitiesOutcomePoliciesPopulationPreventionPublic HealthPublic Health PracticePublicationsQualifyingResearchResearch ActivityResearch PersonnelResearch Project GrantsResearch SupportResource-limited settingRiskServicesStatistical ModelsStructureStudy modelsSurveysTranslatingTranslationsU-Series Cooperative AgreementsUnited States National Institutes of HealthViralWorkYouthbehavioral and social scienceclinical developmentclinical research sitedata infrastructuredata managementeducation researcheffectiveness/implementation studyimplementation scienceimprovedinnovationmultidisciplinaryperformance siteprevention serviceprogramspublic health interventionresearch clinical testingsocial science researchsuccessweb siteworking group
项目摘要
Support Services for the Prevention and Treatment through a Comprehensive Care
Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science
Network (PATC3H-IN) (UG1/UM2) Program
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) requires support for logistical and operational coordination, website and communication management, analytic and data management, infrastructure for emerging research, regulatory, and monitoring of research activities for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN) (UG1/UM2) Program.
The NICHD and partner NIH Institutes anticipate funding 8 PATC3H-IN UG1 awards in Asia and throughout sub-Saharan Africa in 2023 through a cooperative agreement mechanism for interventions of high public health significance: The prevention of new HIV infections among adolescents at risk, and the identification of, linkage to and retention in care of, and long-term viral suppression among youth living with HIV in low-to-middle income countries with high HIV burden. The PATC3H-IN network will expand and/or improve on successes achieved by its predecessor, PATC3H, to new geographic settings and/or risk populations and stimulate much needed implementation science (IS) research in the prevention of new HIV infections among adolescents at risk and the identification of, and linkage and retention to care of and long-term viral suppression among youth living with HIV in low-to-middle income countries (LMICs). PATC3H-IN will establish a network of investigators with multidisciplinary expertise on the youth-specific PHCC and in IS research, whose mission will be to evaluate promising prevention innovations contextually and developmentally tailored for HIV uninfected at-risk youth, and treatment and care interventions for youth living with HIV which have demonstrated efficacy and/or effectiveness in adolescent or adult populations and to translate them into public health practices.
The structure of PATC3H-IN will consist of multiple interdependent functional components: (1) Five Clinical Research Centers (CRC) awarded through the UG1 grant mechanism; (2) one Implementation Science Coordinating Center (ISCC) to be awarded through a UM2 grant mechanism in 2024; and (3) a Scientific Leadership Committee (SLC). The CRCs will conduct clinical research and clinical trials, including implementation, effectiveness, and hybrid implementation-effectiveness studies at their 8-or more participating Clinical Research Performance Sites (CRPS). The ISCC will establish infrastructure to support research education and capacity building across PATC3H-IN, as well as infrastructure for stakeholder engagement in and dissemination of findings from PATC3H-IN and advanced statistical modeling support across PATC3H-IN. The ISCC will also provide infrastructure for conducting foundational research to support the work of clinical sites, including possible modeling studies and translation projects, as well as national surveys, and/or systematic collection and analysis of relevant policies and laws. Lastly, the SLC will be responsible for PATC3H-IN governance, oversight, and coordination, and will develop and implement the network research agenda, convening working groups as needed, prioritizing emerging research projects, efficiently managing the development of clinical protocols, implementing and completing clinical trials, and ensuring timely publication and communication of results.
通过全面护理预防和治疗的支助服务
资源受限环境中受艾滋病毒影响的青少年的连续体实施科学
网络(PATC 3 H-IN)(UG 1/UM 2)程序
Eunice Kennedy Shriver国家儿童健康和人类发展研究所(NICHD)需要支持后勤和业务协调,网站和通信管理,分析和数据管理,新兴研究的基础设施,监管,通过对资源有限环境中受艾滋病毒影响的青少年的连续全面护理进行预防和治疗的研究活动执行科学网(PATC 3 H-IN)(UG 1/UM 2)程序。
NICHD和合作伙伴NIH研究所预计将通过合作协议机制,为2023年亚洲和整个撒哈拉以南非洲地区的8个PATC 3 H-IN UG 1奖项提供资金,用于具有高度公共卫生意义的干预措施:预防高危青少年中新的艾滋病毒感染,查明艾滋病毒感染者,在艾滋病毒负担高的中低收入国家,艾滋病毒感染者中的年轻人长期受到病毒抑制。PATC 3 H-IN网络将扩大和/或改进其前身PATC 3 H取得的成功,以适应新的地理环境和/或风险人群,并促进急需的实施科学研究,以预防风险青少年中新的艾滋病毒感染,以及在中低收入国家(LMIC)感染艾滋病毒的青年中与护理和长期病毒抑制的联系和保留。PATC 3 H-IN将建立一个研究人员网络,该网络具有针对青年的PHCC和IS研究的多学科专业知识,其使命将是评估有前景的预防创新,为未感染艾滋病毒的高危青年量身定制,已证明有效的艾滋病毒感染青年治疗和护理干预措施,或在青少年或成年人群中的有效性,并将其转化为公共卫生实践。
PATC 3 H-IN的结构将由多个相互依存的功能组件组成:(1)通过UG 1资助机制授予的五个临床研究中心(CRC);(2)将通过2024年UM 2资助机制授予的一个实施科学协调中心(ISCC);以及(3)科学领导委员会(SLC)。CRC将在其8个或更多参与临床研究绩效研究中心(CRPS)开展临床研究和临床试验,包括实施、有效性和混合实施-有效性研究。ISCC将建立基础设施,以支持PATC 3 H-IN的研究教育和能力建设,以及利益相关者参与和传播PATC 3 H-IN的研究结果的基础设施,以及PATC 3 H-IN的高级统计建模支持。ISCC还将为开展基础研究提供基础设施,以支持临床研究中心的工作,包括可能的建模研究和翻译项目,以及国家调查和/或相关政策和法律的系统收集和分析。最后,SLC将负责PATC 3 H-IN的管理、监督和协调,并将制定和实施网络研究议程,根据需要召集工作组,优先考虑新兴研究项目,有效管理临床方案的制定,实施和完成临床试验,并确保及时发布和交流结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
BARBARA DRIVER其他文献
BARBARA DRIVER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('BARBARA DRIVER', 18)}}的其他基金
SUPPORT SERVICES FOR HIV AIDS CLINICAL TRIAL NETWORKS
HIV 艾滋病临床试验网络的支持服务
- 批准号:
10872942 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
CORE NICHD NETWORK CLINICAL SITE SUPPORT FOR IMPAACT RELATED STUDIES
核心 NICHD 网络临床站点支持影响相关研究
- 批准号:
10792687 - 财政年份:2022
- 资助金额:
$ 146.15万 - 项目类别:
STUDY CLOSEOUT FOR THE INTERNATIONAL COHORT STUDY OF CHILDREN BORN TO WOMEN INFECTED WITH ZIKA VIRUS DURING PREGNANCY (ZIP 2.0)
对怀孕期间感染寨卡病毒的妇女所生儿童的国际队列研究即将结束 (ZIP 2.0)
- 批准号:
10701122 - 财政年份:2022
- 资助金额:
$ 146.15万 - 项目类别:
PHASE I STUDY OF PHARMACOKINETICS, SAFETY AND ACCEPTABILITY OF A SINGLE DOSE OF PRETOMANID ADDED TO AN OPTIMIZED BACKGROUND REGIMEN IN CHILDREN WITH RIFAMPICIN RESISTANT TUBERCULOSIS IMPAACT 2034
对患有利福平耐药结核病儿童的单剂量 Pretomanid 的药代动力学、安全性和可接受性的 I 期研究添加到优化背景方案中的影响 2034
- 批准号:
10679271 - 财政年份:2022
- 资助金额:
$ 146.15万 - 项目类别:
SUPPORT SERVICES OF THE HIV AIDS CLINICAL TRIAL NETWORKS
HIV艾滋病临床试验网络的支持服务
- 批准号:
10792689 - 财政年份:2022
- 资助金额:
$ 146.15万 - 项目类别:
A5418 STUDY OF TECOVIRIMAT FOR HUMAN MONKEYPOX VIRUS (STOMP)
A5418 TECOVIRIMAT 针对人猴痘病毒 (STOMP) 的研究
- 批准号:
10710436 - 财政年份:2022
- 资助金额:
$ 146.15万 - 项目类别:
IMPAACT RELATED PROTOCOLS FOR THE RESEARCH ON TREATMENT, PREVENTION, DIAGNOSIS AND EPIDEMIOLOGY OF HIV INFECTIONS
HIV 感染的治疗、预防、诊断和流行病学研究的影响相关方案
- 批准号:
10369859 - 财政年份:2021
- 资助金额:
$ 146.15万 - 项目类别:
SECONDARY DATA ANALYSES AND INVESTIGATION OF RESEARCH CONCEPT PROPOSALS FROM THE PROSPECTIVE COHORT OF HIV AND ZIKA IN INFANTS AND PREGNANCY STUDY (HIV-ZIP)
二手数据分析和调查婴儿和妊娠研究中艾滋病毒和寨卡病毒前瞻性队列的研究概念提案 (HIV-ZIP)
- 批准号:
10576710 - 财政年份:2021
- 资助金额:
$ 146.15万 - 项目类别:
ZIP 2.0 STUDY CHILD COHORT WITH INTERIM ANALYSIS OF AGE 30 MONTHS DATA
ZIP 2.0 研究儿童队列,对 30 个月龄数据进行中期分析
- 批准号:
10396161 - 财政年份:2021
- 资助金额:
$ 146.15万 - 项目类别:
HIV AND OTHER IMPAACT RELATED INFECTIOUS DISEASE STUDIES
艾滋病毒和其他影响相关的传染病研究
- 批准号:
9916163 - 财政年份:2019
- 资助金额:
$ 146.15万 - 项目类别:
相似海外基金
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The impact of changes in social determinants of health on adolescent and young adult mental health during the COVID-19 pandemic: A longitudinal study of the Asenze cohort in South Africa
COVID-19 大流行期间健康社会决定因素的变化对青少年和年轻人心理健康的影响:南非 Asenze 队列的纵向研究
- 批准号:
10755168 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
A Priority Setting Partnership to Establish a Patient, Caregiver, and Clinician-identified Research Agenda for Adolescent and Young Adult Cancer in Canada
建立优先合作伙伴关系,以建立患者、护理人员和临床医生确定的加拿大青少年和年轻人癌症研究议程
- 批准号:
480840 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
Miscellaneous Programs
Incidence and Time on Onset of Cardiovascular Risk Factors and Cardiovascular Disease in Adult Survivors of Adolescent and Young Adult Cancer and Association with Exercise
青少年和青年癌症成年幸存者心血管危险因素和心血管疾病的发病率和时间以及与运动的关系
- 批准号:
10678157 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
Fertility experiences among ethnically diverse adolescent and young adult cancer survivors: A population-based study
不同种族青少年和年轻成年癌症幸存者的生育经历:一项基于人群的研究
- 批准号:
10744412 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
Treatment development for refractory leukemia using childhood/adolescent, and young adult leukemia biobank
利用儿童/青少年和青年白血病生物库开发难治性白血病的治疗方法
- 批准号:
23K07305 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular design of Two-Way Player CAR-T cells to overcome disease/antigen heterogeneity of childhood, adolescent, and young adult cancers
双向 CAR-T 细胞的分子设计,以克服儿童、青少年和年轻成人癌症的疾病/抗原异质性
- 批准号:
23H02874 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Effects of adolescent social isolation on adult decision making and corticostriatal circuitry
青少年社会隔离对成人决策和皮质纹状体回路的影响
- 批准号:
10756652 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
Adolescent trauma produces enduring disruptions in sleep architecture that lead to increased risk for adult mental illness
青少年创伤会对睡眠结构产生持久的破坏,从而导致成人精神疾病的风险增加
- 批准号:
10730872 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别:
Using Tailored mHealth Strategies to Promote Weight Management among Adolescent and Young Adult Cancer Survivors
使用量身定制的移动健康策略促进青少年和年轻癌症幸存者的体重管理
- 批准号:
10650648 - 财政年份:2023
- 资助金额:
$ 146.15万 - 项目类别: