SUPPORT SERVICES FOR THE PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS IMPLEMENTATION SCIENCE NETWORK

通过全面护理连续体为资源有限环境中受艾滋病毒影响的青少年提供预防和治疗支持服务 实施科学网络

• 批准号: 10917617
• 负责人: BARBARA DRIVER
• 金额: $ 146.15万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-25 至 2024-08-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10917617
• 关键词: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Affect; Africa South of the Sahara; Age; Asia; Award; Brazil; Caring; Childhood; Clinical Protocols; Clinical Research; Clinical Trials; Collection; Communicable Diseases; Communication; Communities; Comprehensive Health Care; Continuity of Patient Care; Contracts; Country; Development; Education; Effectiveness; Ensure; Equipment; Family; Funding; Geography; Goals; Grant; HIV; HIV Infections; Health; Health system; Human Resources; Incidence; Income; Individual; Information Systems; Infrastructure; Intervention; Laws; Leadership; Mission; Monitor; National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; Outcome; Policies; Population; Prevention; Public Health; Public Health Practice; Publications; Qualifying; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resource-limited setting; Risk; Services; Statistical Models; Structure; Study models; Surveys; Translating; Translations; U-Series Cooperative Agreements; United States National Institutes of Health; Viral; Work; Youth; behavioral and social science; clinical development; clinical research site; data infrastructure; data management; education research; effectiveness/implementation study; implementation science; improved; innovation; multidisciplinary; performance site; prevention service; programs; public health intervention; research clinical testing; social science research; success; web site; working group

Support Services for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN) (UG1/UM2) Program The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) requires support for logistical and operational coordination, website and communication management, analytic and data management, infrastructure for emerging research, regulatory, and monitoring of research activities for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN) (UG1/UM2) Program. The NICHD and partner NIH Institutes anticipate funding 8 PATC3H-IN UG1 awards in Asia and throughout sub-Saharan Africa in 2023 through a cooperative agreement mechanism for interventions of high public health significance: The prevention of new HIV infections among adolescents at risk, and the identification of, linkage to and retention in care of, and long-term viral suppression among youth living with HIV in low-to-middle income countries with high HIV burden. The PATC3H-IN network will expand and/or improve on successes achieved by its predecessor, PATC3H, to new geographic settings and/or risk populations and stimulate much needed implementation science (IS) research in the prevention of new HIV infections among adolescents at risk and the identification of, and linkage and retention to care of and long-term viral suppression among youth living with HIV in low-to-middle income countries (LMICs). PATC3H-IN will establish a network of investigators with multidisciplinary expertise on the youth-specific PHCC and in IS research, whose mission will be to evaluate promising prevention innovations contextually and developmentally tailored for HIV uninfected at-risk youth, and treatment and care interventions for youth living with HIV which have demonstrated efficacy and/or effectiveness in adolescent or adult populations and to translate them into public health practices. The structure of PATC3H-IN will consist of multiple interdependent functional components: (1) Five Clinical Research Centers (CRC) awarded through the UG1 grant mechanism; (2) one Implementation Science Coordinating Center (ISCC) to be awarded through a UM2 grant mechanism in 2024; and (3) a Scientific Leadership Committee (SLC). The CRCs will conduct clinical research and clinical trials, including implementation, effectiveness, and hybrid implementation-effectiveness studies at their 8-or more participating Clinical Research Performance Sites (CRPS). The ISCC will establish infrastructure to support research education and capacity building across PATC3H-IN, as well as infrastructure for stakeholder engagement in and dissemination of findings from PATC3H-IN and advanced statistical modeling support across PATC3H-IN. The ISCC will also provide infrastructure for conducting foundational research to support the work of clinical sites, including possible modeling studies and translation projects, as well as national surveys, and/or systematic collection and analysis of relevant policies and laws. Lastly, the SLC will be responsible for PATC3H-IN governance, oversight, and coordination, and will develop and implement the network research agenda, convening working groups as needed, prioritizing emerging research projects, efficiently managing the development of clinical protocols, implementing and completing clinical trials, and ensuring timely publication and communication of results.

通过全面护理预防和治疗的支助服务 资源受限环境中受艾滋病毒影响的青少年的连续体实施科学 网络（PATC 3 H-IN）（UG 1/UM 2）程序 Eunice Kennedy Shriver国家儿童健康和人类发展研究所（NICHD）需要支持后勤和业务协调，网站和通信管理，分析和数据管理，新兴研究的基础设施，监管，通过对资源有限环境中受艾滋病毒影响的青少年的连续全面护理进行预防和治疗的研究活动执行科学网（PATC 3 H-IN）（UG 1/UM 2）程序。 NICHD和合作伙伴NIH研究所预计将通过合作协议机制，为2023年亚洲和整个撒哈拉以南非洲地区的8个PATC 3 H-IN UG 1奖项提供资金，用于具有高度公共卫生意义的干预措施：预防高危青少年中新的艾滋病毒感染，查明艾滋病毒感染者，在艾滋病毒负担高的中低收入国家，艾滋病毒感染者中的年轻人长期受到病毒抑制。PATC 3 H-IN网络将扩大和/或改进其前身PATC 3 H取得的成功，以适应新的地理环境和/或风险人群，并促进急需的实施科学研究，以预防风险青少年中新的艾滋病毒感染，以及在中低收入国家（LMIC）感染艾滋病毒的青年中与护理和长期病毒抑制的联系和保留。PATC 3 H-IN将建立一个研究人员网络，该网络具有针对青年的PHCC和IS研究的多学科专业知识，其使命将是评估有前景的预防创新，为未感染艾滋病毒的高危青年量身定制，已证明有效的艾滋病毒感染青年治疗和护理干预措施，或在青少年或成年人群中的有效性，并将其转化为公共卫生实践。 PATC 3 H-IN的结构将由多个相互依存的功能组件组成：（1）通过UG 1资助机制授予的五个临床研究中心（CRC）;（2）将通过2024年UM 2资助机制授予的一个实施科学协调中心（ISCC）;以及（3）科学领导委员会（SLC）。CRC将在其8个或更多参与临床研究绩效研究中心（CRPS）开展临床研究和临床试验，包括实施、有效性和混合实施-有效性研究。ISCC将建立基础设施，以支持PATC 3 H-IN的研究教育和能力建设，以及利益相关者参与和传播PATC 3 H-IN的研究结果的基础设施，以及PATC 3 H-IN的高级统计建模支持。ISCC还将为开展基础研究提供基础设施，以支持临床研究中心的工作，包括可能的建模研究和翻译项目，以及国家调查和/或相关政策和法律的系统收集和分析。最后，SLC将负责PATC 3 H-IN的管理、监督和协调，并将制定和实施网络研究议程，根据需要召集工作组，优先考虑新兴研究项目，有效管理临床方案的制定，实施和完成临床试验，并确保及时发布和交流结果。