SUPPORT SERVICES FOR THE PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS (PATC3H) (UG3/UH3) PROGRAM

介绍 尤妮斯·肯尼迪·施莱佛国家儿童健康和人类发展研究所 （NICHD）需要支持后勤和业务协调、网站和通信 管理，监管和监测预防和治疗研究活动 通过对资源有限的受艾滋病毒影响的青少年的全面护理 设置（PATC 3 H）（UG 3/UH 3）程序。 NICHD和合作伙伴NIH研究所在巴西和整个亚热带地区资助了8个PATC 3 H奖项。 2018年撒哈拉非洲通过分阶段创新合作协议机制， 具有高度公共卫生意义的干预措施： 青少年的风险，并确定，联系和保留在照顾， 在艾滋病毒高负担的中低收入国家，艾滋病毒感染者中的青年受到抑制。 研究人员将评估针对几个层面的各种创新组合干预措施， 包括个人、家庭、诊所、社区、结构和教育及卫生系统。项目 包括与当地机构和监管机构合作，包括政策和计划领导人， 推进研究目标的实现，并最大限度地实现和可持续性， 有效的干预措施和最佳做法。 目标 本任务订单将提供所有必要的服务、合格人员、材料、设备， 支持a）后勤和业务协调，B）监管基础设施所需的设施 c）网站管理和通信 管理所有8个PATC 3 H研究项目的研究活动，以进行临床试验， 评估针对个人、家庭、诊所、社区的各种综合干预措施， 在结构、教育和卫生系统各级改善青少年的健康状况， 艾滋病毒感染者和青年的风险。 https://www.patc3h.org/SitePages/Home.aspx 本任务订单的执行期为一个基准年和4个备选年或最多5年 年

Introduction The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) requires support for logistical and operational coordination, website and communication management, regulatory, and monitoring of research activities for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) (UG3/UH3) Program. The NICHD and partner NIH Institutes have funded 8 PATC3H awards in Brazil and throughout sub- Saharan Africa in 2018 through a phased innovation cooperative agreement mechanism for interventions of high public health significance: The prevention of new HIV infections among adolescents at risk, and the identification of, linkage to and retention in care of, and long-term viral suppression among youth living with HIV in low-to-middle income countries with high HIV burden. Investigators will evaluate a variety of innovative combination interventions aimed at several levels, including individual, family, clinic, community, structural and education and health systems. Projects include collaborations with local agencies and regulatory bodies, including policy and program leaders, to advance achievement of the research objectives, and maximize implementation and sustainability of efficacious interventions and best practices. Objectives This Task Order will provide all the necessary services, qualified personnel, materials, equipment, and facilities needed for support of a) logistical and operational coordination, b) regulatory infrastructure and monitoring of non-registrational trials, and c) website administration and communication management of research activities for all 8 PATC3H research projects to conduct clinical trials for the evaluation of a variety of combination interventions aimed at the individual, family, clinic, community, structural and education and health systems levels to improve health outcomes among adolescents at risk for and youth living with HIV. https://www.patc3h.org/SitePages/Home.aspx The period of performance of this task order is a base year and 4 option years or a maximum of 5 years.