SUPPORT SERVICES FOR THE PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS (PATC3H) (UG3/UH3) PROGRAM

引言 尤尼斯·肯尼迪·施莱弗国家儿童健康和人类发展研究所 (NICHD)需要在后勤和业务协调、网站和通信方面提供支持 预防和治疗研究活动的管理、管理和监测 通过对资源受限的艾滋病毒感染青少年进行全面护理 设置(PATC3H)(UG3/UH3)程序。 NICHD和合作伙伴NIH研究所在巴西和整个分地区资助了8个PATC3H奖项 2018年撒哈拉非洲通过阶段性创新合作协议机制 具有高度公共卫生意义的干预措施：在 处于危险中的青少年，以及识别、关联和保留照顾和长期病毒 在艾滋病毒负担较高的低收入到中等收入国家，对感染艾滋病毒的青年进行抑制。 调查人员将评估针对多个层面的各种创新组合干预措施， 包括个人、家庭、诊所、社区、结构以及教育和卫生系统。项目 包括与当地机构和监管机构合作，包括政策和方案领导人， 促进研究目标的实现，并最大限度地实施和维持 有效的干预措施和最佳做法。 目标 该任务订单将提供所有必要的服务、合格的人员、材料、设备和 A)后勤和业务协调、b)监管基础设施所需的支助设施 和监测非注册试验，以及c)网站管理和通信 管理所有8个PATC3H研究项目的研究活动，以进行 评估针对个人、家庭、诊所、社区、 结构、教育和卫生系统层面，以改善青少年的健康状况 艾滋病毒携带者和青少年的风险。 Https://www.patc3h.org/SitePages/Home.aspx 此任务订单的履约期间为基准年和4个选项年或最多5年 好几年了。

Introduction The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) requires support for logistical and operational coordination, website and communication management, regulatory, and monitoring of research activities for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) (UG3/UH3) Program. The NICHD and partner NIH Institutes have funded 8 PATC3H awards in Brazil and throughout sub- Saharan Africa in 2018 through a phased innovation cooperative agreement mechanism for interventions of high public health significance: The prevention of new HIV infections among adolescents at risk, and the identification of, linkage to and retention in care of, and long-term viral suppression among youth living with HIV in low-to-middle income countries with high HIV burden. Investigators will evaluate a variety of innovative combination interventions aimed at several levels, including individual, family, clinic, community, structural and education and health systems. Projects include collaborations with local agencies and regulatory bodies, including policy and program leaders, to advance achievement of the research objectives, and maximize implementation and sustainability of efficacious interventions and best practices. Objectives This Task Order will provide all the necessary services, qualified personnel, materials, equipment, and facilities needed for support of a) logistical and operational coordination, b) regulatory infrastructure and monitoring of non-registrational trials, and c) website administration and communication management of research activities for all 8 PATC3H research projects to conduct clinical trials for the evaluation of a variety of combination interventions aimed at the individual, family, clinic, community, structural and education and health systems levels to improve health outcomes among adolescents at risk for and youth living with HIV. https://www.patc3h.org/SitePages/Home.aspx The period of performance of this task order is a base year and 4 option years or a maximum of 5 years.