淋巴细胞功能的分子遗传学分析-猫眼课题宝

淋巴细胞功能的分子遗传学分析

批准号：

10927729

负责人：

David Margulies

金额：

$76.58万

依托单位：

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/10927729

关键词：

Address Affinity Antibodies Antigen-Presenting Cells Antigens Area Autoimmunity Bacterial Infections Biochemical Biological Cancerous Cell surface Cells Collaborations Communicable Diseases Complex Cryoelectron Microscopy Engineering Family Generations Goals Histocompatibility Human Immune response Immune system Lymphocyte Function Malignant Neoplasms Molecular Molecular Biology Molecular Genetics Monoclonal Antibodies Monoclonal Antibody Therapy Mus Myeloid Cells NK Cell Activation Natural Killer Cells Nature Parasitic infection Pathologic Peptide/MHC Complex Peptides Predisposition Process Proteins Reaction Receptor Cell Recombinants Regulation Roentgen Rays Role Site Stress T-Cell Receptor Viral Physiology Virus Diseases genetic analysis immune activation immune system function in vitro Model in vivo interest nonhuman primate receptor response three dimensional structure trafficking tumor

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中文摘要

翻译

我们对几种PAN-抗MHC-I单抗与其MHC-I(人类白细胞抗原-I)抗原相互作用的结构基础的研究形成了几种工程形式的单抗的基础。关于它们相互作用的分子细节以及它们对各种NK和髓系细胞受体的竞争性阻断作用的性质，人们正在积极研究。结构和生化研究构成了非人类灵长类动物计划功能研究的基础，它们将成为进一步人性化和亲和力成熟研究的主题。随着信息的积累，我们预计这些单抗及其衍生物可能成为旨在开发针对各种肿瘤的单抗疗法的新研究的基础。

英文摘要

Our studies of the structural basis by which several pan-anti-MHC-I mAb interact with their MHC-I (HLA-I) antigens form the basis of several engineered forms of the mAb. These are being actively studied with respect to the molecular details of their interactions and the nature of their competitive blocking effects on various NK and myeloid cell receptors. The structural and biochemical studies form the basis of planned functional studies in non-human primates, and they will be the subject of further humanization and affinity maturation studies. As information accumulates, we expect that these mAb and their derivatives may form the basis of new studies aimed at developing mAb therapies for various tumors.

期刊论文(11)

专著(0)

科研奖励(0)

会议论文

Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides.

DOI： 10.3389/fimmu.2020.629399

发表时间： 2020

期刊：

Frontiers in immunology

影响因子： 7.3

作者：

[Puig M, Ananthula S, Venna R, Kumar Polumuri S, Mattson E, Walker LM, Cardone M, Takahashi M, Su S, Boyd LF, Natarajan K, Abdoulaeva G, Wu WW, Roderiquez G, Hildebrand WH, Beaucage SL, Li Z, Margulies DH, Norcross MA]

通讯作者： Norcross MA

The in-betweeners: MAIT cells join the innate-like lymphocytes gang.

中间者：MAIT 细胞加入了先天性淋巴细胞群。

DOI： 10.1084/jem.2118insight3

发表时间： 2014

期刊：

The Journal of experimental medicine

影响因子： --

作者：

[Margulies,DavidH]

通讯作者： Margulies,DavidH

Chaperones and Catalysts: How Antigen Presentation Pathways Cope With Biological Necessity.

DOI： 10.3389/fimmu.2022.859782

发表时间： 2022

期刊：

Frontiers in immunology

影响因子： 7.3

作者：

[]

通讯作者：

Antigen-processing and presentation pathways select antigenic HIV peptides in the fight against viral evolution.

抗原加工和呈递途径选择抗原性 HIV 肽来对抗病毒进化。

DOI： 10.1038/ni0609-566

发表时间： 2009

期刊：

Nature immunology

影响因子： 30.5

作者：

[Margulies,DavidH]

通讯作者： Margulies,DavidH

Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen.

DOI： 10.1016/j.jaut.2013.06.003

发表时间： 2013-08

期刊：

Journal of autoimmunity

影响因子： 12.8

作者：

[Horai R, Silver PB, Chen J, Agarwal RK, Chong WP, Jittayasothorn Y, Mattapallil MJ, Nguyen S, Natarajan K, Villasmil R, Wang P, Karabekian Z, Lytton SD, Chan CC, Caspi RR]

通讯作者： Caspi RR