Build to LEAD – Building partnerships to Link the Exposome to Autoimmune Disease (Admin Supp)

总结 我们正在申请1 R21 AR 084042“建立领先-建立伙伴关系， 将暴露体与自身免疫性疾病联系起来”。行政补充研究属于 积极的家长补助金，这是重点建立合作团队，参加博览会， 自身免疫疾病协作团队（EXACT）网络。所有EXACT网络网站将研究如何 环境暴露影响自身免疫性疾病的易感性、发病和结果。这一行政 补充将提供一个机会，建立额外的合作，扩大自身免疫暴露体 首脑会议提出的母赠款和扩大协调麻烦的数据收集的所有成员 精确网络。行政补充文件有三个具体目标。具体目标1： 与环境接触方面的专家建立更多的合作，并增加 专家顾问在家长补助金。具体目标2建议扩大自身免疫暴露体 首脑会议和相关工作组和咨询小组，以吸收更多具有以下专长的关键利益攸关方： 家长补助金，但关键的精确网络。这可能包括儿科自身免疫性疾病的专家 和健康的社会决定因素。具体目标3建议扩大麻烦数据的统一 收集到精确的网络。这将包括对整个网络中的麻烦数据进行景观分析， 确定和选择与生物样本相关的最佳处理方案， 在未来的EXACT网络研究中统一现有数据的共同优先事项。值得注意的是，所有拟议的 这项工作将与美国国立卫生研究院和EXACT网络协商完成，并将成为未来EXACT的基础 网络研究。拟议的工作是在母奖的范围内，因为它的重点是建立 合作小组研究的作用，麻烦的发展和进展的自身免疫性 疾病

SUMMARY We are requesting an Administrative Supplement for 1R21AR084042 “Build to LEAD – Building partnerships to Link the Exposome to Autoimmune Disease”. The Administrative Supplement studies are within the scope of the active parent grant, which is focused on establishing collaborative teams to participate in the Exposome in Autoimmune Diseases Collaborating Teams (EXACT) Network. All EXACT Network sites will study how environmental exposures influence autoimmune disease susceptibility, onset and outcomes. This Administrative Supplement will provide an opportunity to establish additional collaborations, expand the Autoimmune Exposome Summits proposed in the parent grant and expand harmonization of exposome data collection to all members of the EXACT Network. The Administrative Supplement has three Specific Aims. Specific Aim 1 proposes to establish additional collaborations with experts in environmental exposures and to increase the involvement of the expert consultants in the parent grant. Specific Aim 2 proposes to expand the Autoimmune Exposome Summits and related working and advisory groups to include additional key stakeholders with expertise beyond the parent grant but critical for the EXACT Network. This could include experts in pediatric autoimmune diseases and social determinants of health. Specific Aim 3 proposes to expand the harmonization of exposome data collection to the EXACT Network. This will include a landscape analysis of exposome data across the network, identification and selection of optimal processing protocols for exposure-associated biospecimens and defining shared priorities for existing data to be harmonized in future EXACT Network studies. Notably, all of the proposed work will be done in consultation with NIH and the EXACT Network and will be foundational for future EXACT Network studies. The proposed work is within the scope of the parent award as it focuses on establishing collaborative teams for studying the role of the exposome in the development and progression of autoimmune disease.