Build to LEAD – Building partnerships to Link the Exposome to Autoimmune Disease (Admin Supp)

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SUMMARY We are requesting an Administrative Supplement for 1R21AR084042 “Build to LEAD – Building partnerships to Link the Exposome to Autoimmune Disease”. The Administrative Supplement studies are within the scope of the active parent grant, which is focused on establishing collaborative teams to participate in the Exposome in Autoimmune Diseases Collaborating Teams (EXACT) Network. All EXACT Network sites will study how environmental exposures influence autoimmune disease susceptibility, onset and outcomes. This Administrative Supplement will provide an opportunity to establish additional collaborations, expand the Autoimmune Exposome Summits proposed in the parent grant and expand harmonization of exposome data collection to all members of the EXACT Network. The Administrative Supplement has three Specific Aims. Specific Aim 1 proposes to establish additional collaborations with experts in environmental exposures and to increase the involvement of the expert consultants in the parent grant. Specific Aim 2 proposes to expand the Autoimmune Exposome Summits and related working and advisory groups to include additional key stakeholders with expertise beyond the parent grant but critical for the EXACT Network. This could include experts in pediatric autoimmune diseases and social determinants of health. Specific Aim 3 proposes to expand the harmonization of exposome data collection to the EXACT Network. This will include a landscape analysis of exposome data across the network, identification and selection of optimal processing protocols for exposure-associated biospecimens and defining shared priorities for existing data to be harmonized in future EXACT Network studies. Notably, all of the proposed work will be done in consultation with NIH and the EXACT Network and will be foundational for future EXACT Network studies. The proposed work is within the scope of the parent award as it focuses on establishing collaborative teams for studying the role of the exposome in the development and progression of autoimmune disease.