Rod and Cone Mediated Function in Retinal Disease

视杆细胞和视锥细胞在视网膜疾病中介导的功能

基本信息

  • 批准号:
    10930530
  • 负责人:
  • 金额:
    $ 74.29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
  • 资助国家:
    美国
  • 起止时间:
  • 项目状态:
    未结题

项目摘要

Specific Aim 1: To establish the normal ranges of dark-adapted retinal sensitivities for the Medmont, and for RF hyperacuity function on the Display++ monitor in healthy volunteers. We have established normal range for the Medmont dark adaptometer and RF hyperacuity measures for the Display++. We amended this protocol to add new fundus-guided and non-guided perimeters to the protocol. Since the last review we have recruited 23 healthy volunteers to establish normal ranges for a range of tests (e.g. scotopic thresholds, ERG) on new instruments. Specific Aim 2: To establish the normal ranges for the kinetics of dark adaptation for the Medmont DAC blue and red stimuli in healthy volunteers. We have established the normal range for dark adaptation with the Medmont dark adaptometer. Since the last review we have recruited 16 healthy volunteers (subset of HV from Aim 1) to establish the normal range of dark adaptation for the MonCvONE perimeter. Specific Aim 3: To quantify local changes in rod and cone photoreceptor function across the retina in participants with retinal disease. We have studied rod function and dark adaptation, from seven members of a family with late-onset retinal degeneration (L-ORD). We have followed several members longitudinally and plan to continue following these patients. We developed a new test of rod function based on scotopic contour and shape discrimination (Flynn and Jeffrey, PMID: 30747948). Last year we published our results using this novel test to examine early changes in rod mediated function in participants with intermediate age-related macular degeneration (iAMD) with or without reticular pseudodrusen (RPD). (Jeffrey BG et al. PMID: 35749129.)
具体目标1:在健康志愿者中建立Medmont暗适应视网膜灵敏度的正常范围,以及Display++监视器上RF超敏功能的正常范围。我们已经建立了Medmont暗适应计和Display++的RF超敏度测量的正常范围。 我们修改了该方案,在方案中添加了新的眼底引导和非引导周长。 自上一次审查以来,我们招募了23名健康志愿者,在新仪器上建立一系列测试(例如暗视阈值,ERG)的正常范围。 具体目标2:确定健康志愿者中Medmont DAC蓝色和红色刺激的暗适应动力学的正常范围。 我们用Medmont暗适应仪建立了暗适应的正常范围。自上次审查以来,我们招募了16名健康志愿者(目标1中的HV子集),以确定MonCvONE视野计的暗适应正常范围。 具体目标3:量化视网膜疾病受试者视网膜上视杆细胞和视锥细胞感光功能的局部变化。我们研究了晚发性视网膜变性(L-ORD)家族的7名成员的视杆细胞功能和暗适应。 我们已经纵向跟踪了几位成员,并计划继续跟踪这些患者。我们开发了一种基于暗视轮廓和形状辨别的新的视杆功能测试(Flynn和Jeffrey,PMID:30747948)。 去年,我们发表了我们的结果,使用这种新的测试来检查有或没有网状假性玻璃疣(RPD)的中度年龄相关性黄斑变性(iAMD)参与者中杆介导功能的早期变化。 (Jeffrey BG等人PMID:35749129.)

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brett Jeffrey其他文献

Brett Jeffrey的其他文献

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{{ truncateString('Brett Jeffrey', 18)}}的其他基金

Rod and Cone Mediated Function in Retinal Disease
视杆细胞和视锥细胞在视网膜疾病中介导的功能
  • 批准号:
    10246743
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:
An Observational Cross-Sectional Study of Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
视网膜疾病功能性视觉虚拟现实移动性评估的观察横断面研究
  • 批准号:
    10706149
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:
The Focal Electro-Oculogram in Macular Disease
黄斑疾病的局灶眼电图
  • 批准号:
    9362431
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:
Color Vision in Inherited Retinal Degenerations
遗传性视网膜变性中的色觉
  • 批准号:
    8938363
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:
Color Vision in Inherited Retinal Degenerations
遗传性视网膜变性中的色觉
  • 批准号:
    9155612
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:
The Focal Electro-Oculogram in Macular Disease
黄斑疾病的局灶眼电图
  • 批准号:
    9555712
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:
Color Vision in Inherited Retinal Degenerations
遗传性视网膜变性中的色觉
  • 批准号:
    9555700
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:
Color Vision in Inherited Retinal Degenerations
遗传性视网膜变性中的色觉
  • 批准号:
    8737687
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:
Rod and Cone Mediated Function in Retinal Disease
视杆细胞和视锥细胞在视网膜疾病中介导的功能
  • 批准号:
    9555713
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:
An Observational Prospective Natural History Study of Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4
ELOVL4 突变继发的 Stargardt 样黄斑营养不良 (STDG3) 的观察性前瞻性自然史研究
  • 批准号:
    10706152
  • 财政年份:
  • 资助金额:
    $ 74.29万
  • 项目类别:

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