STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
批准号:
2023473
负责人:
P Andrew Evans
金额:
$10.9万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-05-01 至 2002-04-30
中文摘要
描述:该提案的目的是应用新颖的
分子内酰基自由基环化合成
重要的环醚。 尽管存在多种合成方法
这些化合物的研究,寻找增加骨骼和
立体化学灵活性继续存在。 酰基已收到
作为有机合成中的活性中间体,其关注相对有限,
尽管它们具有有效形成碳-碳键的潜力。 PI 的
初步综合研究表明,该方法可能
对于目标定向合成具有重要的实用性。
本文提出的合成研究将集中于制备
cis-kumausyne、kumausallene 以及制定可行的策略
强效抗真菌剂龙胆酸A-D。 龙胆酸A-D
代表已知最有效的抗真菌剂,其活性超过
两性霉素 B 的浓度提高了三个数量级以上,使它们
极其重要的目标。
英文摘要
DESCRIPTION: The aim of the proposal is the application of novel
intramolecular acyl radical cyclizations to the synthesis of biologically
important cyclic ethers. Although numerous methods exist for the synthesis
of these compounds, the search for new methods with increased skeletal and
stereochemical flexibility continues. Acyl radicals have received
relatively limited attention as reactive intermediates in organic synthesis,
despite their potential to efficiently form carbon-carbon bonds. The PI's
preliminary synthetic studies indicate that this methodology is likely to
have significant utility for target directed synthesis.
The synthetic studies proposed herein will focus on the preparation of
cis-kumausyne, kumausallene, and the development of a viable strategy for
the potent antifungal agents gamberic acids A-D. The gamberic acids A-D
represent the most potent antifungal agents known, with activity exceeding
that of amphotericin B by over three orders of magnitude, making them
extremely important targets.
期刊论文(0)
专著(0)
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会议论文
NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
-
批准号:6500648
-
项目类别:
-
资助金额:$17.91万
-
财政年份:2001
-
负责人:P Andrew Evans
-
依托单位:
STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
-
批准号:6423825
-
项目类别:
-
资助金额:$2.81万
-
财政年份:2001
-
负责人:P Andrew Evans
-
依托单位:
NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
-
批准号:6434411
-
项目类别:
-
资助金额:$11.15万
-
财政年份:2001
-
负责人:P Andrew Evans
-
依托单位:
New Rhodium-Catalyzed Allylic Alkylation Reactions
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批准号:7092149
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项目类别:
-
资助金额:$24.89万
-
财政年份:1999
-
负责人:P Andrew Evans
-
依托单位:
New Rhodium-Catalyzed Allylic Alkylation Reactions
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批准号:6914924
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项目类别:
-
资助金额:$25.51万
-
财政年份:1999
-
负责人:P Andrew Evans
-
依托单位:
New Rhodium-Catalyzed Allylic Alkylation Reactions
-
批准号:6822051
-
项目类别:
-
资助金额:$25.54万
-
财政年份:1999
-
负责人:P Andrew Evans
-
依托单位:
New Rhodium-Catalyzed Allylic Alkylation Reactions
-
批准号:7167124
-
项目类别:
-
资助金额:$6.82万
-
财政年份:1999
-
负责人:P Andrew Evans
-
依托单位:
NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
-
批准号:6181094
-
项目类别:
-
资助金额:$6.13万
-
财政年份:1999
-
负责人:P Andrew Evans
-
依托单位:
NEW RHODIUM CATALYZED ALLYLIC ALKYLATION REACTIONS
-
批准号:2909009
-
项目类别:
-
资助金额:$20.86万
-
财政年份:1999
-
负责人:P Andrew Evans
-
依托单位:
STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
-
批准号:6181202
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项目类别:
-
资助金额:$7.94万
-
财政年份:1997
-
负责人:P Andrew Evans
-
依托单位:
STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
-
批准号:2701772
-
项目类别:
-
资助金额:$9.89万
-
财政年份:1997
-
负责人:P Andrew Evans
-
依托单位:
Stereoselective Synthesis of Cyclic Ethers
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批准号:6838201
-
项目类别:
-
资助金额:$25.06万
-
财政年份:1997
-
负责人:P Andrew Evans
-
依托单位:
Stereoselective Synthesis of Cyclic Ethers
-
批准号:6731751
-
项目类别:
-
资助金额:$25.09万
-
财政年份:1997
-
负责人:P Andrew Evans
-
依托单位:
STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
-
批准号:2910262
-
项目类别:
-
资助金额:$10.32万
-
财政年份:1997
-
负责人:P Andrew Evans
-
依托单位:
STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
-
批准号:6386539
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1997
-
负责人:P Andrew Evans
-
依托单位:
Stereoselective Synthesis of Cyclic Ethers
-
批准号:7010028
-
项目类别:
-
资助金额:$24.45万
-
财政年份:1997
-
负责人:P Andrew Evans
-
依托单位:
STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
-
批准号:6569978
-
项目类别:
-
资助金额:$5.36万
-
财政年份:1997
-
负责人:P Andrew Evans
-
依托单位:
海外基金