New Rhodium-Catalyzed Allylic Alkylation Reactions

描述（由申请人提供）：以下提案的目的是发展区域和对映体特异性铑催化的烯丙基取代作为一般交叉偶联反应，并与自由基环化和新型金属催化的碳环化反应相结合。预计这些过程将促进新策略的设计和应用，使生物重要分子的快速全合成成为可能。

DESCRIPTION (provided by applicant): The aim of the following proposal is the development of the regio- and enantiospecific rhodium-catalyzed allylic substitution as a general cross-coupling reaction, and the combination with free radical cyclization and novel metal-catalyzed carbocyclization reactions. It is anticipated that these processes will facilitate the design and application of novel strategies that permit the expeditious total synthesis of the biological important molecules. The specific areas of interest are summarized as follows: New Allylic Amination Reactions with Cyclic Vinylogous Amides and Ureas: the development of new allylic amination reactions with vinylogous amides and ureas for the total synthesis of the alkaloids, lepadiformine and batzelladine D. New Metal-Catalyzed Carbocyclization Reactions: enantioselective metal-catalyzed [2+2+2] carbocyclization reactions using chiral rhodium complexes, and the combination with allylic substitutions for new tandem processes. The development of a temporary silicon-tethered (TST) rhodium-catalyzed [4+2+2] carbocyclization approach to the diterpene, epoxydictymene.