NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS

新的铑催化烯丙基烷基化反应

• 批准号: 6181094
• 负责人: P Andrew Evans
• 金额: $ 6.13万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6181094
• 关键词: alkylation; amination; chemical addition; podophyllin; rhodium; stereochemistry

DESCRIPTION: (Applicant's Abstract) The aim of the following proposal is the development of the asymmetric rhodium-catalyzed allylic alkylation reaction, and the application of this unique chemistry to the synthesis of biologically important natural products. The rhodium-catalyzed allylic alkylation reaction represents a powerful method for the construction of common stereochemical motifs present in a variety of complex biologically important natural products and is particularly useful for the asymmetric synthesis of acyclic ternary and quaternary carbon stereogenic centers. Further development and application of this chemistry is necessary in order to define the scope and limitations of this important synthetic transformation. Preliminary studies will focus on the examination of stabilized carbon and nitrogen nucleophiles.

描述：(申请人摘要)以下提案的目的是 不对称Rh催化的烯丙基烷基化反应的研究进展 以及这种独特的化学在生物合成中的应用 重要的天然产物。Rh催化的烯丙基烷基化反应 代表了一种构建通用立体化学结构的有效方法 存在于各种复杂的具有生物重要性的天然产品中的基元 特别适用于不对称合成无环三元和 第四纪碳立体中心。二次开发和应用 这种化学是必要的，以便确定 这一重要的综合转变。初步研究将集中在 稳定的碳和氮亲核试剂的检验。