NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS

描述：（申请人的摘要）以下提议的目的是： 不对称铑催化的烯丙基烷基化反应的发展， 以及这种独特的化学方法在生物合成中的应用 重要的天然产品。铑催化的烯丙基烷基化反应 代表了构建常见立体化学的强有力方法 存在于各种复杂的生物学重要的天然产物中的基序 并且特别适用于无环三元和 季碳立体中心。进一步发展和应用 这种化学反应是必要的，以便定义范围和限制， 这一重要的合成转化。初步研究将集中在 稳定的碳和氮亲核试剂的检验。

DESCRIPTION: (Applicant's Abstract) The aim of the following proposal is the development of the asymmetric rhodium-catalyzed allylic alkylation reaction, and the application of this unique chemistry to the synthesis of biologically important natural products. The rhodium-catalyzed allylic alkylation reaction represents a powerful method for the construction of common stereochemical motifs present in a variety of complex biologically important natural products and is particularly useful for the asymmetric synthesis of acyclic ternary and quaternary carbon stereogenic centers. Further development and application of this chemistry is necessary in order to define the scope and limitations of this important synthetic transformation. Preliminary studies will focus on the examination of stabilized carbon and nitrogen nucleophiles.