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XENOPUS WNT GENES IN MESODERMAL AND NEURAL PATTERNING

XENOPUS WNT GENES IN MESODERMAL AND NEURAL PATTERNING
爪蟾 WNT 基因在中胚层和神经模式中的作用
批准号:
2025491
负责人:
Jan L Christian
金额:
$8.8万
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-01-01 至 1998-12-31

项目摘要

项目成果

Jan L Christian的其他基金

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中文摘要
翻译
描述(改编自申请人摘要):长期目标
英文摘要
DESCRIPTION (adapted from applicant's abstract): The long term goal of the proposed research is to understand the molecular mechanisms by which Wnts convey developmental information in vertebrates. A primary goal of the present study is to examine the mechanisms by which wnt-8 contributes to abnormal or normal patterning by testing the hypotheses (a) that misexpression of Xwnt-8 in anterior mesoderm either retards the normal involution of this tissue or alters its neural inducing activity thereby leading to a loss of forebrain and (b) that misexpression of Xwnt-8 in prospective dorsal mesoderm leads to identifiable changes in gene expression that promote ventral rather than dorsal differentiation. A number of related Xenopus Wnts have been identified whose developmental functions remain unexplored. One such gene, Xwnt-8b, which is more closely related to Xwnt-8 than it is to other Wnts, is transiently expressed during the same developmental stages as Xwnt-8 but in different cell types. To initiate functional analysis of Xwnt-8b and to examine structure/function relationships to both Xwnt-8b and Xwnt-8, Dr. Christian will test the hypotheses: (a) that maintenance of the usual expression pattern of Xwnt-8b is required for normal embryonic patterning and (b) that specific, identifiable domains of Xwnt-8 and Xwnt-8b mediate their distinct biological activities and biochemical characteristics. Specific aims are: (1) analysis of mechanisms underlying the Xwnt-8 mediated loss of forebrain; (2) identification and cloning of zygotic genes involved in dorsal or ventral specification; (3) cloning of the complete coding region of the Xwnt-8b cDNA; (4) analysis of embryonic expression of Xwnt-8b transcripts; (5) perturbation of normal expression of Xwnt-8b; and (6) identification of functional domains of Xwnt-8b.
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Analysis of BMP Heterodimer formation and function
  • 批准号:
    10371195
  • 项目类别:
  • 资助金额:
    $19.06万
  • 财政年份:
    2021
  • 负责人:
    Jan L Christian
  • 依托单位:
Analysis of BMP Heterodimer Formation and Function
  • 批准号:
    10406484
  • 项目类别:
  • 资助金额:
    $6.77万
  • 财政年份:
    2021
  • 负责人:
    Jan L Christian
  • 依托单位:
Analysis of BMP Heterodimer formation and function
  • 批准号:
    10593673
  • 项目类别:
  • 资助金额:
    $3.16万
  • 财政年份:
    2021
  • 负责人:
    Jan L Christian
  • 依托单位:
Novel Developmental Regulation of Bmp and nodal signaling by Tril
  • 批准号:
    9921215
  • 项目类别:
  • 资助金额:
    $31.64万
  • 财政年份:
    2012
  • 负责人:
    Jan L Christian
  • 依托单位:
国内基金
海外基金
ITS-HPLC-HRMS-Bioassay多级筛选策略指导下海洋真菌中新型抗菌活性产物的发现