TOTAL SYNTHESES OF BIOACTIVE MOLECULES VIA VINYL SULFONE

该提议寻求合成本发明化合物的天然对映体。 具有生物学意义的天然产物（1）Roseophilin;（2） （3）伊博替丁。 第四个目标是发展 合成卤代吲哚的一种新的成环方法。 整个计划旨在扩大乙烯砜化学的范围 用于合成上述天然产物。 一个额外的统一 特点是研究偶氮烯和过渡金属化学， 实现吡咯和吲哚的构建和/或递送， 目标生物碱的部分。

This proposal seeks to synthesize the natural enantiomers of the biologically significant natural products (1) Roseophilin; (2) Pancratistatin; and (3) Ibogaine. A fourth goal is the development of a new annulation procedure for synthesis of halogenated indoles. The overall program seeks to expand the scope of vinyl sulfone chemistry for the synthesis of the above natural products. An additional unifying feature is the investigation of azoene and transition metal chemistry to achieve the construction and/or delivery of the pyrrole and indole portions of the targeted alkaloids.