PLACENTAL DEFECTS UNDERLIE FETAL WATER DISEASE

胎盘缺陷是胎儿水病的根源

• 批准号: 2403265
• 负责人: Kent L.R. Thornburg
• 金额: $ 15.14万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2403265
• 关键词: amniotic fluid; diffusion; edema; electrical conductance; human pregnant subject; hydrostatic pressure; insulin; membrane permeability; membrane potentials; osmotic pressure; perfusion; placenta disorders; placental transfer; thiosulfate; vitamin B12; water flow

Fetal water diseases, which include hydrops fetalis and polyhydramnios, are an increasingly common cause of infant mortality and morbidity. Nearly all fetuses with the non-immune form do not survive. Yet the mechanisms that underlie the pathophysiology are unknown. This application is based on the umbrella hypothesis that a number of primary fetal abnormalities cause fetal water diseases through a common pathway-alterations in the physicochemical properties of the placental barrier. The application is designed to quantitate missing pieces of data that will allow us to estimate the physical forces that regulate the movement of water across the placenta in normal and diseased patients. Aim l of the study is to measure the diffusion permeability of the tracer substances of different molecular weights and charges in normal placentas from pregnancies with water disease. Aim 2 is to estimate the hydraulic conductivity and reflection coefficients of several important molecular species from the in vitro perfused placentas of hydropic and polyhydramniotic patients and from normal control patients. The data for these two specific aims will provide the basis for predicting the roles of disturbances in the forces that drive water across the placenta under normal and pathological conditions.

胎儿水疾病，包括胎儿水肿和羊水过多， 是造成婴儿死亡和发病的一个日益普遍的原因。近 所有具有非免疫形式的胎儿不能存活。 然而， 病理生理学的基础是未知的。 本申请基于 关于一些原发性胎儿畸形 导致胎儿水疾病通过一个共同的途径-改变在 胎盘屏障的理化性质。应用程序 旨在量化缺失的数据， 估计调节水运动的物理力量， 正常和患病患者的胎盘。 研究的目的是 测量不同的示踪物质的扩散渗透率， 正常胎盘中的分子量和电荷 水病。 目的2是估算水力传导系数， 反射系数的几个重要的分子物种从 羊水过多和羊水过多患者的体外灌注胎盘， 正常对照组患者。 这两个具体目标的数据将 为预测扰动在部队中的作用提供了基础 在正常和病理情况下， 条件

项目成果

Localization of fibrillin-1 in the human term placenta.

fibrillin-1 在人类足月胎盘中的定位。

• DOI: 10.1016/1071-5576(95)97405-6
• 发表时间: 1995
• 期刊: Journal of the Society for Gynecologic Investigation
• 作者: Jacobson,SL;Kimberly,D;Thornburg,K;Maslen,C
• 通讯作者: Maslen,C