PEDIATRIC AIDS CLINICAL TRIALS GROUP

儿科艾滋病临床试验组

• 批准号: 2003814
• 负责人: WALTER T HUGHES
• 金额: $ 114.9万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2003814
• 关键词: 2'3' dideoxycytidine; 2'3' dideoxyinosine; AIDS; AIDS /HIV test; AIDS education /prevention; AIDS vaccines; Mycobacterium avium; Pneumocystis carinii; Pneumocystis pneumonia; Streptococcus pneumoniae vaccine; adolescence (12-20); antiviral agents; antiviral antibody; atovaquone; chemoprevention; child (0-11); clinical research; clinical trial phase I; combination chemotherapy; community; congenital infection; cooperative study; cytomegalovirus; dapsone; data management; drug administration routes; epidemiology; family; flow cytometry; ganciclovir; gene therapy; health behavior; human immunodeficiency virus 1; human pregnant subject; human subject; immunotherapy; measles vaccine; microorganism disease chemotherapy; monoclonal antibody; neuropsychological tests; nevirapine; opportunistic infections; outcomes research; passive immunization; pathologic process; pediatric AIDS; pharmacokinetics; phenotype; polymerase chain reaction; premature infant human; protease inhibitor; retinitis; social service; stavudine; tissue /cell culture; vertical transmission; virus DNA; virus RNA; virus infection mechanism; zidovudine

A pediatric AIDS Clinical Trials Unit (PACTU) is proposed for St. Jude Children's Research Hospital with subunits at the University of Tennessee, (Le Bonheur Children's Medical Center and The Med), the Methodist Hospital and Vanderbilt University Medical center. The objective is to support the scientific agenda of the coordinating and Operations Center (CORC) proposed by Spector et al. and the NIAID) HIV/AIDS research agenda set forth in 1995. The team off the proposed PACTU includes well established academic specialists in pediatric and adult infectious diseases, immunology, pharmacology, virology, pharmaceutical science, pediatric neurology, psychology, neonatology, fetal and maternal medicine, vaccinology, oncology and gene transfer- based therapy. Each of the three children's hospitals have ongoing clinics for pediatric AIDS and the hospitals provide three separate obstetrical and neonatal programs with experience in maternal and infant AIDS. Over the past five years the St. Jude PACTU has demonstrated excellence as an innovative, productive, interactive site for the AUG program of the NIAID). We now plan to build on the existing program by addition of esteemed colleagues, state-of-the-art facilities and expanded clientele of HIV-infected infants, children and women at Vanderbilt University. This, in turn, provides access for all HIV- infected children throughout Tennessee and its seven bordering states to ACTG protocols and experimental drugs and vaccines. The high density population of African-Americans in the mid-South and the rapid increase of HIV infection in adolescents of this group assure an ample sample of HIV-infected pregnant women and their infants, as well as non- pregnant adolescents for study. Because of the strength of our experience in pharmacology, phrmacokinetics and new drug development we intend to take a major role in phase I and I/II studies of new compounds. A second major emphasis will be on HIV-infected adolescents because of unique features of these older pediatric patients, the prevalence of these individuals in our catchment area and our well established collaboration with specialists in internal medicine who share our, interest in AIDS research.

一个儿科艾滋病临床试验单位（PACTU）建议圣裘德 儿童研究医院，在哥伦比亚大学设有分部。 田纳西州，（Le Bonheur儿童医疗中心和医学）， 卫理公会医院和范德比尔特大学医学中心。的 目标是支持协调和 运营中心（CORC）由Spector等人和NIAID提出） 1995年制定了艾滋病毒/艾滋病研究议程。该小组提出， PACTU包括儿科和儿科领域的知名学术专家， 成人传染病，免疫学，药理学，病毒学， 药学，小儿神经病学，心理学，神经病学， 胎儿和母亲医学，疫苗学，肿瘤学和基因转移- 基于治疗。三家儿童医院都在继续 儿科艾滋病诊所和医院提供三个独立的 产科和新生儿方案，在孕产妇和 婴儿艾滋病在过去的五年里，圣裘德PACTU已经 作为一个创新、高效、互动的网站， （参见NIAID的AUG计划）。我们现在计划在现有的基础上再接再厉 通过增加受人尊敬的同事，最先进的设施， 感染艾滋病毒的婴儿、儿童和妇女的服务对象扩大， 范德比尔特大学。这反过来又为所有艾滋病毒感染者提供了机会- 田纳西州及其周边七个州的受感染儿童 ACTG协议和实验性药物和疫苗。高密度 美国中南部非洲裔人口的迅速增长 这组青少年中艾滋病毒感染的比例确保了充足的样本 感染艾滋病毒的孕妇及其婴儿，以及 怀孕的青少年进行研究。 因为我们的力量 药理学、药理学和新药开发经验 我们打算在第一阶段和第一/第二阶段的新研究中发挥重要作用， 化合物.第二个主要重点将是感染艾滋病毒的青少年 由于这些老年儿科患者的独特特征， 这些人在我们的集水区和我们的井中的患病率 与内科专家建立了合作关系， 分享我们对艾滋病研究的兴趣。