Effects of environmental contaminants on anxiety-like and fear behaviors, and gut-microbiota in rodents
环境污染物对啮齿动物焦虑样和恐惧行为以及肠道微生物群的影响
基本信息
- 批准号:10908899
- 负责人:
- 金额:$ 6.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAgricultureAmygdaloid structureAnimalsAnxietyBacteriaBehaviorBehavioralBiologicalBrainBrain regionBreathingChemicalsClinicalConsumptionDarknessDevelopmentDillDiseaseDoseEmotional disorderEnvironmental PollutantsEnvironmental PollutionEnzymesEventExposure toFOS geneFemaleFoodFood PreservativesFreezingFrightFunctional disorderFutureGoalsGonadal HormonesGrantHealthHerbicidesHistologyHumanKnowledgeLightLinkMammalsMeasuresMemory impairmentMental disordersMetabolicMinority GroupsMissionMovementNational Institute of Environmental Health SciencesNational Institute of Mental HealthNational Institute on Minority Health and Health DisparitiesNeurodevelopmental DisorderNeurologicNeuronsNeurotransmittersPathogenesisPathway interactionsPlantsPredispositionPrefrontal CortexRattusReportingResearch Domain CriteriaResistanceRiskRodentRoleRouteSamplingSerotoninSex DifferencesStructureStructure of terminal stria nuclei of preoptic regionTestingTimeToxic Environmental SubstancesUnited States Environmental Protection AgencyUnited States Food and Drug AdministrationUnited States National Institutes of HealthWateranxiety-like behaviorarmbehavior changebehavior testbehavioral studybrain circuitrycomparison controlconditioned fearcontaminated drinking watercontaminated waterdrinkingdysbiosisemotion dysregulationexposed human populationfear memoryfecal microbiotaglyphosategut microbesgut microbiotaindustrial productionmalemicrobial based therapymicroorganismneuralpathogenpreclinical studyresponsesexshikimatesymbiont
项目摘要
Project Summary
Our goal is to understand the effects of environmental contaminants, namely glyphosate, on
anxiety-like and fear-related behaviors, and determine possible links between gut microbial
imbalances and behavioral deficits. The increased risk of human exposure to chemicals from
food preservatives, agriculture and industrial production suggests a link between exposure to
environmental toxins, such as glyphosate, and the development of neurological and emotional
disorders. Glyphosate, the active ingredient in glyphosate-based herbicides, was initially
considered safe for mammals since it exerts its effect by inhibiting a metabolic route not present
in mammals. However, this enzyme is found in microorganism, making the gut microbiota likely
susceptible to damage by glyphosate. Given that the gut microbiota benefits the host, by acting
as a defense against pathogens, producing neurotransmitters such as serotonin, and regulating
normal brain function, disturbances of the gut microbiota may contribute to neural pathogenesis
by generating a cascade of events which lead to emotional dysregulation. Thus, glyphosate can
impact the health of animals by acting against their gut microbes. The influence of glyphosate
on anxiety-like and fear-related behaviors is unclear. To evaluate the potential relationship
between the influence of glyphosate on anxiety, fear, and gut microbiota, a link must be
examined. Understanding how glyphosate impacts rat gut symbionts, their behavior and brain
pathophysiology will help elucidate a possible role of this chemical to anxiety and fear. We will
give either glyphosate-contaminated drinking water or filtered water, to adult rats, and perform
behavioral studies for anxiety-like and fear-related behaviors. We hypothesize that prolonged
drinking of glyphosate-contaminated water will lead to increased anxiety-like and fear-related
behaviors. In addition, by evaluating for changes in the composition of gut microbiota, we will
identify microbial imbalances that may correlate with the development of emotional disorders.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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FILIPA GODOY-VITORINO其他文献
FILIPA GODOY-VITORINO的其他文献
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{{ truncateString('FILIPA GODOY-VITORINO', 18)}}的其他基金
Effects of environmental contaminants on anxiety-like and fear behaviors, and gut-microbiota in rodents
环境污染物对啮齿动物焦虑样和恐惧行为以及肠道微生物群的影响
- 批准号:
10816154 - 财政年份:2023
- 资助金额:
$ 6.91万 - 项目类别:
Effects of environmental contaminants on anxiety-like and fear behaviors, and gut-microbiota in rodents
环境污染物对啮齿动物焦虑样和恐惧行为以及肠道微生物群的影响
- 批准号:
10693846 - 财政年份:2022
- 资助金额:
$ 6.91万 - 项目类别:
Effects of environmental contaminants on anxiety-like and fear behaviors, and gut-microbiota in rodents
环境污染物对啮齿动物焦虑样和恐惧行为以及肠道微生物群的影响
- 批准号:
10433395 - 财政年份:2022
- 资助金额:
$ 6.91万 - 项目类别:
Cross-sectional associations of oral microbiota with oral HPV infection among high-risk Hispanic adults
高危西班牙裔成年人口腔微生物群与口腔 HPV 感染的横断面关联
- 批准号:
10003477 - 财政年份:2018
- 资助金额:
$ 6.91万 - 项目类别:
Pilot Project 1: Combination of Viroimmunotherapy and Microbiota Modulation to Treat Gastric Cancer
试点项目 1:病毒免疫疗法与微生物群调节相结合治疗胃癌
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10247755 - 财政年份:2002
- 资助金额:
$ 6.91万 - 项目类别:
Pilot Project 1: Combination of Viroimmunotherapy and Microbiota Modulation to Treat Gastric Cancer
试点项目 1:病毒免疫疗法与微生物群调节相结合治疗胃癌
- 批准号:
10247768 - 财政年份:2002
- 资助金额:
$ 6.91万 - 项目类别:
Pilot Project 1: Combination of Viroimmunotherapy and Microbiota Modulation to Treat Gastric Cancer
试点项目 1:病毒免疫疗法与微生物群调节相结合治疗胃癌
- 批准号:
10021569 - 财政年份:2002
- 资助金额:
$ 6.91万 - 项目类别:
The Microbiome as a risk factor for hr-HPV persistence and Cervical Cancer
微生物组是 hr-HPV 持续存在和宫颈癌的危险因素
- 批准号:
10707134 - 财政年份:1997
- 资助金额:
$ 6.91万 - 项目类别:
The Microbiome as a risk factor for hr-HPV persistence and Cervical Cancer
微生物组是 hr-HPV 持续存在和宫颈癌的危险因素
- 批准号:
10556249 - 财政年份:1997
- 资助金额:
$ 6.91万 - 项目类别:
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