NIDCD Core for Clinical Research and Care
NIDCD 临床研究和护理核心
基本信息
- 批准号:10923716
- 负责人:
- 金额:$ 304.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AQP1 geneAdministratorAdmission activityAdultAmbulatory Care FacilitiesAppointmentAreaAudiologyCCRCare given by nursesCaringChildChromosome MappingCisplatinClinicalClinical ClerkshipClinical DataClinical InvestigatorClinical ResearchClinical ServicesClinical TrialsClinics and HospitalsCommunication impairmentComplexConsultConsultationsContinuing EducationCredentialingDataData CollectionDatabasesDevelopmentDiseaseDoseEmergency SituationEndoscopyEquilibriumEquipment and SuppliesEvaluationFellowshipFosteringGenesGenetic studyHead and Neck DisorderHead and Neck Squamous Cell CarcinomaHead and Neck SurgeonHearingHearing problemHereditary DiseaseHospital AdministrationHospitalsHourHumanHuman ResourcesImageIndiaInpatientsInstitutional Review BoardsInterventionIntervention StudiesIntramural Research ProgramLaboratoriesLabyrinthMaintenanceMedicalMedical StudentsMentorsMissionMolecularMolecular AnalysisMonitorNational Institute on Deafness and Other Communication DisordersNatural HistoryNeoadjuvant TherapyNurse PractitionersNursing ResearchOlfactory NeuroblastomaOperative Surgical ProceduresOtolaryngologistOtolaryngologyOutpatientsPakistanParotid GlandPathogenesisPatient CarePatient EducationPatientsPhasePhenotypePhysiciansProgram DevelopmentProtocols documentationProviderRecordsRecurrent respiratory papillomatosisResearchResearch SupportResourcesSafetySalivaryScientistServicesSpecimenSpeechSupervisionSurgeonTestingTimeTrainingTravelUnited States National Institutes of HealthVestibular AqueductVisitVoiceWorkadeno-associated viral vectoratorvastatinbevacizumabcareer developmentcisplatin induced hearing lossclinical careclinical implementationdata managementgenetic analysisgenetic deafnessgenome editinghearing impairmenthearing restorationhereditary hearing losshuman papilloma virus oropharyngeal squamous cell carcinomahuman subjectinpatient serviceirradiationmeetingsototoxicityoutpatient programspatient screeningphase 2 studyphotoimmunotherapyprogramsprotocol developmentquality assurancerecruitresponsesymposiumvolunteer
项目摘要
The NIDCD Core for Clinical Research and Care supports the following NIDCD projects:
1 ZIA DC000039 Identification of Genes Causing Syndromic and Nonsyndromic Hearing Impairment
1 ZIA DC000046 Genetic Studies of Human Communications Disorders
1 ZIA DC000060 Molecular Analysis of Human Hereditary Deafness
1 ZIA DC000064 Clinical Analysis of Disorders Of Hearing And Balance
1 ZIA-DC-000082 Neurotology Program
1-ZIA-DC-000088 Cellular and Molecular Pathogenesis of Hearing Restoration in Adult Inner Ear
The NIDCD and collaborative protocols supported by the core include:
OH93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol
97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment
01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment with Enlarged Vestibular Aqueducts
01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance
12-DC-0152 - Normative values in audiovestibular testing
17-DC-0138 - Cisplatin and statins in ototoxcity
18-DC-0051 - NIDCD Biospecimens protocol
20-DC-0047 - Natural History and Genome Editing in Dominant Hearing Loss
21-DC-0002- Phase III Interventional Study using Atorvastatin to Reduce Cisplatin-Induced Hearing Loss
21-C-0009 - A Natural History Study of Children and Adults with Olfactory Neuroblastoma
000077 Clinical Data and Specimens in head and neck disorders
000141 Hearing Instability Phenotyping
15-D-0129 Dose-Escalation Study Evaluating the Safety of a Single Administration of an Adeno-Associated Virus Vector Encoding Human Aquaporin-1 in Irradiation-Induced Parotid Salivary Hypofunction
04C0165 - Data Collection, Clinical Care and Interventions in CCR, NCI
001572 - A Phase II Study of Bevacizumab in Adults with Recurrent Respiratory Papillomatosis (RRP)
21C0013: PRGN-2012 in Recurrent Respiratory Papillomatosis
20C0024: Neoadjuvant IO for head and neck squamous cell carcinoma
20C0104: Combo Immunotx in HPV oropharyngeal squamous cell carcinoma
000462: ASP-1929 Photoimmunotherapy
The NIDCD Core for Clinical Research and Care supports over 3,000 outpatient clinic evaluations per year. Core otolaryngologists perform 50-100 major surgical cases annually. Staff mentor medical students during senior clinical clerkships. The Otolaryngologist Surgeon Scientist Career Development Program is coordinated through the OCD.
NIDCD临床研究和护理核心支持以下NIDCD项目:
1 ZIA DC 000039综合征型和非综合征型听力障碍基因的鉴定
1 ZIA DC 000046人类交流障碍的遗传学研究
1 ZIA DC 000060人类遗传性耳聋的分子分析
1 ZIA DC 000064听力和平衡障碍的临床分析
1 ZIA-DC-000082神经耳科项目
1-ZIA-DC-000088成人内耳听力恢复的细胞和分子发病机制
核心支持的NIDCD和协作协议包括:
OH 93-DC-0016 -非综合征型遗传性听力障碍基因定位:印度/巴基斯坦方案
97-DC-0180 -人类遗传性听力障碍的遗传分析
01-DC-0228 -前庭水管扩大性听力损害的临床和分子分析
01-DC-0229-遗传性听力和平衡障碍的遗传分析
12-DC-0152 -听觉前庭测试的标准值
17-DC-0138 -顺铂和他汀类药物治疗耳毒性
18-DC-0051 - NIDCD生物标本方案
20-DC-0047 -显性听力损失的自然史和基因组编辑
21-DC-0002-使用阿托伐他汀减少顺铂诱导的听力损失的III期干预研究
21-C-0009 -儿童和成人嗅神经母细胞瘤的自然史研究
000077头颈部疾病的临床数据和标本
000141听力不稳定表型
15-D-0129剂量递增研究,评价编码人水通道蛋白-1的腺相关病毒载体单次给药治疗辐射诱导的腮腺唾液功能减退症的安全性
04 C 0165-CCR中的数据收集、临床护理和干预,NCI
001572 -贝伐珠单抗治疗复发性呼吸道乳头状瘤病(RRP)成人的II期研究
21 C 0013:PRGN-2012治疗复发性呼吸道乳头状瘤病
20 C 0024:头颈部鳞状细胞癌的新辅助IO
20 C 0104:Combo Immunotx治疗HPV口咽鳞状细胞癌
000462:ASP-1929光免疫疗法
NIDCD临床研究和护理核心每年支持3 000多个门诊诊所评估。核心耳鼻喉科医生每年进行50-100例大手术。在高级临床实习期间,工作人员指导医学生。耳鼻喉科医生外科医生科学家职业发展计划通过OCD协调。
项目成果
期刊论文数量(18)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Otologic manifestations of Fanconi anemia and other inherited bone marrow failure syndromes.
范可尼贫血和其他遗传性骨髓衰竭综合征的耳科表现。
- DOI:10.1002/pbc.26155
- 发表时间:2016
- 期刊:
- 影响因子:3.2
- 作者:Kalejaiye,Adedoyin;Giri,Neelam;Brewer,CarmenC;Zalewski,ChristopherK;King,KellyA;Adams,CharleenD;Rosenberg,PhilipS;Kim,HJeffrey;Alter,BlancheP
- 通讯作者:Alter,BlancheP
Mechanisms of hearing loss in neurofibromatosis type 2.
2型神经纤维瘤病中听力丧失的机制。
- DOI:10.1371/journal.pone.0046132
- 发表时间:2012
- 期刊:
- 影响因子:3.7
- 作者:Asthagiri AR;Vasquez RA;Butman JA;Wu T;Morgan K;Brewer CC;King K;Zalewski C;Kim HJ;Lonser RR
- 通讯作者:Lonser RR
Trismus and voice change after starting tuberculosis treatment.
- DOI:10.1016/j.idcr.2021.e01307
- 发表时间:2021
- 期刊:
- 影响因子:1.5
- 作者:Rocco JM;Hammoud DA;Allen CT;Galindo F;Laidlaw E;Sereti I
- 通讯作者:Sereti I
Surgical resection of endolymphatic sac tumors in von Hippel-Lindau disease: findings, results, and indications.
von Hippel-Lindau病中内淋巴囊肿瘤的手术切除:发现,结果和适应症。
- DOI:10.1002/lary.23646
- 发表时间:2013-03
- 期刊:
- 影响因子:0
- 作者:Kim HJ;Hagan M;Butman JA;Baggenstos M;Brewer C;Zalewski C;Linehan WM;Lonser RR
- 通讯作者:Lonser RR
Discrimination task reveals differences in neural bases of tinnitus and hearing impairment.
- DOI:10.1371/journal.pone.0026639
- 发表时间:2011
- 期刊:
- 影响因子:3.7
- 作者:Husain FT;Pajor NM;Smith JF;Kim HJ;Rudy S;Zalewski C;Brewer C;Horwitz B
- 通讯作者:Horwitz B
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Joshua Levy其他文献
Joshua Levy的其他文献
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