NIDCD Core for Clinical Research and Care

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The NIDCD Core for Clinical Research and Care supports the following NIDCD projects: 1 ZIA DC000039 Identification of Genes Causing Syndromic and Nonsyndromic Hearing Impairment 1 ZIA DC000046 Genetic Studies of Human Communications Disorders 1 ZIA DC000060 Molecular Analysis of Human Hereditary Deafness 1 ZIA DC000064 Clinical Analysis of Disorders Of Hearing And Balance 1 ZIA-DC-000082 Neurotology Program 1-ZIA-DC-000088 Cellular and Molecular Pathogenesis of Hearing Restoration in Adult Inner Ear The NIDCD and collaborative protocols supported by the core include: OH93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment with Enlarged Vestibular Aqueducts 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 12-DC-0152 - Normative values in audiovestibular testing 17-DC-0138 - Cisplatin and statins in ototoxcity 18-DC-0051 - NIDCD Biospecimens protocol 20-DC-0047 - Natural History and Genome Editing in Dominant Hearing Loss 21-DC-0002- Phase III Interventional Study using Atorvastatin to Reduce Cisplatin-Induced Hearing Loss 21-C-0009 - A Natural History Study of Children and Adults with Olfactory Neuroblastoma 000077 Clinical Data and Specimens in head and neck disorders 000141 Hearing Instability Phenotyping 15-D-0129 Dose-Escalation Study Evaluating the Safety of a Single Administration of an Adeno-Associated Virus Vector Encoding Human Aquaporin-1 in Irradiation-Induced Parotid Salivary Hypofunction 04C0165 - Data Collection, Clinical Care and Interventions in CCR, NCI 001572 - A Phase II Study of Bevacizumab in Adults with Recurrent Respiratory Papillomatosis (RRP) 21C0013: PRGN-2012 in Recurrent Respiratory Papillomatosis 20C0024: Neoadjuvant IO for head and neck squamous cell carcinoma 20C0104: Combo Immunotx in HPV oropharyngeal squamous cell carcinoma 000462: ASP-1929 Photoimmunotherapy The NIDCD Core for Clinical Research and Care supports over 3,000 outpatient clinic evaluations per year. Core otolaryngologists perform 50-100 major surgical cases annually. Staff mentor medical students during senior clinical clerkships. The Otolaryngologist Surgeon Scientist Career Development Program is coordinated through the OCD.