Harvard Chemical Biology PhD Program

哈佛大学化学生物学博士项目

• 批准号: 10618154
• 负责人: Emily Patricia Balskus
• 金额: $ 53.05万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618154
• 关键词: Biology; Chemicals; Doctor of Philosophy; programs

Project Summary This application requests support for the PhD Program in Chemical Biology at Harvard University. This profoundly interdisciplinary program trains highly talented students to carry out independent research at the forefront of chemical biology, addressing biological and medical problems using concepts and experimental approaches drawn from many areas of chemistry and biology and developing novel, broadly relevant technologies. The training program offers an extraordinary range of training opportunities in chemical biology. Faculty members at Harvard’s Cambridge campus offer world-class expertise in the disciplines spanning organic chemistry and the molecular life sciences, while faculty members at the Harvard Medical School (HMS) offer outstanding strengths at the interface between the molecular life sciences and biomedical problems. In addition, the Broad Institute of Harvard and MIT is a leader in technology development relevant to genomics, therapeutic discovery and medicine. The Program thus represents a mechanism to transfer concepts and technologies from chemistry to biology, medicine and genomics and vice versa. Students enter the program from a variety of backgrounds. Required coursework in the first year, provides core training in kinetics, chemical structure and reactivity as well as the application of thermodynamic concepts in the context of biology. Students are also required to take courses focused on reproducible research, statistics, and record-keeping as well as teamwork, communication and ethics. A unifying theme of first year coursework and discussions is the role of chemical tools and approaches in dissecting biological pathways. Students also take elective courses in synthetic organic chemistry, microbiology, cell biology, structural biology, genetics and genomics, proteomics, metabolomics and systems biology. They are exposed to an unusual range of technologies and concepts in chemical biology through coursework, interactions with faculty and other students, and Program events such as the Program retreat and Student Data Club. In addition, they develop communication skills, gain teaching experience and receive training in responsible conduct of research. Trainees are also supported in exploring a wide range of careers inside and outside academia. The previous grant supported 10 trainees and we request support for 10 trainees in this new proposal. The Program aims to attract a diverse community of talented students and give them intensive, personalized support as they develop an interdisciplinary understanding of biological questions and chemical concepts and approaches, and gain independence in posing and answering such questions. The program pays particular attention to rigor and reproducibility, training students in the physicochemical basis of the measurements they make and in appropriate techniques, and common pitfalls, in scientific analysis. Training for communication across disciplines and to the lay public is foundational for the Program and is emphasized throughout each student’s career. Communication is also foundational for multiple types of future careers.

项目摘要 该申请要求支持哈佛大学化学生物学博士学位计划。这 深刻的跨学科计划训练备受才华的学生，在 化学生物学的最前沿，使用概念和实验来解决生物学和医学问题 方法来自许多化学和生物学领域，并开发了新颖的，广泛相关的 技术。该培训计划为化学生物学提供了非凡的培训机会。 哈佛大学剑桥校园的教职员工在学科中提供世界一流的专业知识 有机化学和分子生命科学，而哈佛医学院（HMS）的教职员工 在分子生命科学与生物医学问题之间的界面上提供了出色的优势。在 此外，哈佛大学广泛研究所是与基因组学有关的技术发展领导者， 治疗发现和医学。因此，该程序代表了转移概念和的机制 从化学到生物学，医学和基因组学的技术，反之亦然。 学生从各种背景中输入该计划。第一年所需的课程工作提供核心 动力学，化学结构和反应性以及热力学概念的应用 生物学的背景。还要求学生参加专注于可重复的研究，统计数据， 以及记录保存以及团队合作，沟通和道德规范。第一年课程的统一主题 讨论是化学工具和方法在解剖生物途径中的作用。 学生还参加合成有机化学，微生物学，细胞生物学，结构的选修课程 生物学，遗传学和基因组学，蛋白质组学，代谢组学和系统生物学。他们暴露于 通过课程工作，与教师的互动，化学生物学中不寻常的技术和概念范围 以及其他学生，以及计划务虚会和学生数据俱乐部等计划活动。另外，他们 发展沟通技巧，获得教学经验并接受负责任的培训 研究。还支持学员探索学术界内外的各种职业。这 以前的赠款支持10名学员，我们在这项新提案中要求支持10名学员。 该计划旨在吸引一个由才华横溢的学生组成的潜水员社区，并为他们提供密集，个性化的 在对生物学问题和化学概念的跨学科理解时，他们的支持以及 方法，并在提出和回答此类问题时获得独立性。该计划特别支付 注意严谨性和可重复性，以物理基础的测量来培训学生 在科学分析中制作并采用适当的技术和常见的陷阱。沟通培训 跨学科和外行公众是该计划的基础，并且在每个方面都得到强调 学生的职业。交流也是多种未来职业的基础。