Monoclonal antibodies against surface epitopes of Treponema pallidum outer membrane proteins

抗梅毒螺旋体外膜蛋白表面表位的单克隆抗体

• 批准号: 10618194
• 负责人: Michael Anthony Moody
• 金额: $ 57.37万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618194
• 关键词: Affect; Algorithms; Animal Model; Animals; Antibodies; Antigens; B-Lymphocytes; Bacteriophages; Binding; Cell Lineage; Clinical; Clinical Trials; Collaborations; Collection; Data; Diagnostic tests; Disease; Economically Deprived Population; Epitopes; Extracellular Protein; Genetic; Genomics; Goals; HIV-1 vaccine; Human; Immune; Immune Tolerance; Immunologic Factors; Immunology; In Vitro; Infection; Knowledge; Latent Syphilis; Libraries; Macrophage; Mediating; Membrane Proteins; Modeling; Monoclonal Antibodies; Mus; Natural History; Order Spirochaetales; Oryctolagus cuniculus; Outcome; Patients; Peripheral Blood Mononuclear Cell; Persons; Phage Display; Public Health; Reagent; Research Technics; Sampling; Sexually Transmitted Diseases; Specificity; Speed; Surface; Syphilis; Techniques; Testing; Treponema pallidum; Treponema pallidum subspecies pallidum; Vaccine Design; Variant; Work; design; effective therapy; expectation; extracellular; human monoclonal antibodies; immunogenicity; longitudinal human study; low socioeconomic status; men who have sex with men; novel; novel vaccines; passive antibodies; pressure; programs; syphilis vaccine; vaccine candidate; vaccine development; vaccine strategy; vaccinology

ABSTRACT-Project 3: Immunology Syphilis is a sexually transmitted infection caused by Treponema pallidum that remains a significant public health threat. Despite effective testing and treatment algorithms, the rate of syphilis infections is increasing in the US, especially among economically disadvantaged persons. Development of a vaccine will speed elimination of this disease and reduce the burden of syphilis complications including congenital disease. This overall goal of this program is to develop syphilis vaccine candidates, and this project is designed to characterize the immunological factors associated with protection. This project will isolate, characterize, and test monoclonal antibodies against syphilis derived from clinical samples obtained by our collaborators as well as antibodies that are developed in vitro using phage display techniques. The outcome of this work will be a new set of vaccine candidates that can be advanced to clinical trials.

项目3：免疫学 梅毒是一种由梅毒螺旋体引起的性传播感染， 健康威胁。尽管有有效的检测和治疗算法，梅毒感染率仍在上升， 美国，尤其是经济上处于不利地位的人。疫苗的研制将加速 消除这种疾病并减轻包括先天性疾病在内的梅毒并发症的负担。这 该计划的总体目标是开发梅毒候选疫苗，该项目旨在 表征与保护相关的免疫因素。该项目将分离，表征， 我们也从合作者获得的临床样本中检测抗梅毒的单克隆抗体 作为使用噬菌体展示技术在体外开发的抗体。这项工作的成果将是一个 一组新的候选疫苗，可以推进到临床试验。