Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)
新发传染病研究中心协调中心 (EIDRC CC)
基本信息
- 批准号:10879862
- 负责人:
- 金额:$ 40.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-18 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAreaAwardBenchmarkingBiological AssayBiologyCentral AfricaCentral AmericaChildhoodCollaborationsCommunicable DiseasesCommunicationConsensusCoordination and CollaborationCountryDataDiseaseDisease OutbreaksDoctor of PhilosophyEmerging Communicable DiseasesEnsureEpidemicEventFrequenciesFundingGeographic LocationsGoalsHealthHomeHumanInfectious Diseases ResearchInformation ManagementInfrastructureInternationalJointsKnowledgeLaboratoriesLeadershipLocationMedicalMedical ResearchMentorsMorbidity - disease rateNational Institute of Allergy and Infectious DiseasePerformancePersonsPrincipal InvestigatorPrivatizationProceduresProcessProtocols documentationReagentResearchResearch DesignResearch InfrastructureResearch PersonnelResource SharingResourcesScientistSecuritySiteSoutheastern AsiaSpecialistSpecimenSystemTestingTrainingUnited StatesUnited States National Institutes of HealthUniversitiesVaccinesZIKAcareercloud baseddata acquisitiondata qualitydisease transmissionelectronic data capture systemexperienceflexibilityhigh riskimprovedmortalitynext generationprogramsquality assurancerepositoryresponsesocial mediasuccessusabilityweb site
项目摘要
PROJECT SUMMARY/ABSTRACT
Emerging and re-emerging infectious disease (EID) outbreaks that are occurring with increasing frequency in
high-risk areas in South/Central America, West/Central Africa, and Southeast Asia are a threat to the United
States. Documented gaps in research infrastructure limit the capacity to rapidly respond to these outbreaks.
To address this challenge, the National Institute of Allergy and Infectious Diseases (NIAID) is establishing
the Emerging Infectious Disease Research Centers Network (EIDRC-Net) to improve knowledge of EIDs;
leverage existing NIAID international efforts; and develop the capacity to mount effective, flexible, and rapid
outbreak research responses. RTI International and Duke University propose to establish the EIDRC
Coordination Center (EIDRC CC). The RTI-Duke CC will support the EIDRC-Net, which will comprise the
EIDRCs, research sites, the CC, and NIAID by realizing the following aims: (1) enhance EIDRC coordination
and collaboration by providing administrative, communications, logistical, and operational support; (2)
amplify NIAID's capabilities and reach by coordinating and supporting a sustainable, scalable, and adaptable
research infrastructure to optimize resources and knowledge sharing during inter-outbreak periods and to
respond rapidly and effectively during outbreaks; (3) ensure quality and consistency of study data by using
rigorous data and specimen management systems with built-in data quality assurance; (4) ensure quality of
biospecimens, assays, and reagents through harmonization of standard operating procedures across
EIDRC-Net sites and ongoing audit of cross-network procedures; and (5) develop the next generation of
investigators and in-country scientists by establishing a pilot research program that identifies, funds, and
mentors high-quality EIDRC applicants. By successfully accomplishing our five specific aims, the RTI-Duke
team will shift the outbreak research response paradigm by establishing scalable systems, processes, and
resources that not only provide the necessary infrastructure to facilitate EIDRC-Net performance and carry
out CC core functions during inter-outbreak periods, but also can be enhanced and expanded to bolster CC
research surge response activities during outbreaks. The EIDRC CC team will be co-led by multiple Principal
Investigators Donald Brambilla, PhD (RTI), a biostatistician with advanced training in biology and an
experienced CC leader, and Michael Anthony (Tony) Moody, MD (Duke), a pediatric infectious disease
specialist and Chief Medical Officer of the Duke Human Vaccine Institute. Together they bring extensive
scientific expertise, leadership, administrative experience, and international research expertise, including in
geographic locations most relevant to the study of EIDs. This partnership also leverages the operational
efficiency of RTI, a large nonprofit research organization with regional and project offices in over 75
countries, with the scientific rigor of Duke University, a premier university known for its cutting-edge medical
research and home to a state-of-the-art, NIAID-funded Regional Biocontainment Laboratory.
项目概要/摘要
新发和再发传染病 (EID) 的爆发频率越来越高
南美洲/中美洲、西非/中非和东南亚的高风险地区对美国构成威胁
国家。研究基础设施方面记录的差距限制了快速应对这些疫情的能力。
为了应对这一挑战,国家过敏和传染病研究所 (NIAID) 正在建立
新兴传染病研究中心网络 (EIDRC-Net),以提高对 EID 的了解;
利用现有的 NIAID 国际努力;并培养有效、灵活、快速的安装能力
疫情研究应对措施。 RTI International 与杜克大学提议成立 EIDRC
协调中心(EIDRC CC)。 RTI-Duke CC 将支持 EIDRC-Net,其中包括
EIDRC、研究中心、CC 和 NIAID 通过实现以下目标: (1) 加强 EIDRC 协调
通过提供行政、通信、后勤和运营支持进行协作; (2)
通过协调和支持可持续、可扩展和适应性强的项目,扩大 NIAID 的能力和影响范围
研究基础设施,以优化爆发期间的资源和知识共享,并
疫情爆发期间迅速有效地做出反应; (3)通过使用保证研究数据的质量和一致性
严格的数据和样本管理系统,具有内置的数据质量保证; (四)保证质量
通过统一标准操作程序来提供生物样本、分析方法和试剂
EIDRC-Net 站点和跨网络程序的持续审计; (5) 开发下一代
通过建立试点研究计划来识别、资助和资助研究人员和国内科学家
指导高质量的 EIDRC 申请人。通过成功实现我们的五个具体目标,RTI-Duke
团队将通过建立可扩展的系统、流程和
资源不仅提供必要的基础设施来促进 EIDRC-Net 的性能并承载
可以在两次爆发期间发挥 CC 的核心功能,但也可以增强和扩展以支持 CC
研究疫情暴发期间的激增应对活动。 EIDRC CC 团队将由多位负责人共同领导
研究人员 Donald Brambilla 博士 (RTI),一位接受过高级生物学培训的生物统计学家,
经验丰富的 CC 领导者,以及儿科传染病医学博士 Michael Anthony (Tony) Moody
杜克人类疫苗研究所专家兼首席医疗官。他们共同带来了广泛的
科学专业知识、领导力、管理经验和国际研究专业知识,包括
与 EID 研究最相关的地理位置。这种伙伴关系还利用了运营
RTI 是一家大型非营利性研究组织,在超过 75 个地区设有区域和项目办事处
杜克大学是一所以其尖端医学而闻名的一流大学,具有严谨的科学性
该研究中心是 NIAID 资助的最先进的区域生物防护实验室的所在地。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael Anthony Moody其他文献
Michael Anthony Moody的其他文献
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{{ truncateString('Michael Anthony Moody', 18)}}的其他基金
Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)
新发传染病研究中心协调中心 (EIDRC CC)
- 批准号:
10396064 - 财政年份:2020
- 资助金额:
$ 40.49万 - 项目类别:
Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)
新发传染病研究中心协调中心 (EIDRC CC)
- 批准号:
10891936 - 财政年份:2020
- 资助金额:
$ 40.49万 - 项目类别:
Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)
新发传染病研究中心协调中心 (EIDRC CC)
- 批准号:
10616668 - 财政年份:2020
- 资助金额:
$ 40.49万 - 项目类别:
A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidum.
针对梅毒螺旋体外膜蛋白的全球梅毒疫苗。
- 批准号:
10618184 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
Prevalence of syphilis and other sexually transmitted infections in men and transgender women who have sex with men in Cali, Colombia
哥伦比亚卡利男男性行为者和跨性别女性梅毒和其他性传播感染的患病率
- 批准号:
10559087 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidum.
针对梅毒螺旋体外膜蛋白的全球梅毒疫苗。
- 批准号:
9923544 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
Monoclonal antibodies against surface epitopes of Treponema pallidum outer membrane proteins
抗梅毒螺旋体外膜蛋白表面表位的单克隆抗体
- 批准号:
10618194 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidum.
针对梅毒螺旋体外膜蛋白的全球梅毒疫苗。
- 批准号:
10765594 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidum.
针对梅毒螺旋体外膜蛋白的全球梅毒疫苗。
- 批准号:
10806303 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidum.
针对梅毒螺旋体外膜蛋白的全球梅毒疫苗。
- 批准号:
10399442 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
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