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Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)

新发传染病研究中心协调中心 (EIDRC CC)

基本信息

批准号：
10616668
负责人：
Michael Anthony Moody
金额：
$ 245.09万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-18 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10616668
关键词：
Address Affect Area Award Benchmarking Biological Assay Biology Central Africa Central America Childhood Collaborations Communicable Diseases Communication Consensus Coordination and Collaboration Country Data Disease Disease Outbreaks Doctor of Philosophy Emerging Communicable Diseases Ensure Epidemic Event Frequencies Funding Geographic Locations Goals Health Home Human Infectious Diseases Research Information Management Infrastructure International Joints Knowledge Laboratories Leadership Location Medical Medical Research Mentors Morbidity - disease rate National Institute of Allergy and Infectious Disease Performance Persons Principal Investigator Privatization Procedures Process Protocols documentation Reagent Research Research Design Research Infrastructure Research Personnel Resource Sharing Resources Scientist Security Site Southeastern Asia Specialist Specimen System Testing Training United States United States National Institutes of Health Universities Vaccines ZIKA career cloud based data acquisition data quality disease transmission electronic data capture system experience flexibility high risk improved mortality next generation programs quality assurance repository response social media success usability web site

项目摘要

PROJECT SUMMARY/ABSTRACT Emerging and re-emerging infectious disease (EID) outbreaks that are occurring with increasing frequency in high-risk areas in South/Central America, West/Central Africa, and Southeast Asia are a threat to the United States. Documented gaps in research infrastructure limit the capacity to rapidly respond to these outbreaks. To address this challenge, the National Institute of Allergy and Infectious Diseases (NIAID) is establishing the Emerging Infectious Disease Research Centers Network (EIDRC-Net) to improve knowledge of EIDs; leverage existing NIAID international efforts; and develop the capacity to mount effective, flexible, and rapid outbreak research responses. RTI International and Duke University propose to establish the EIDRC Coordination Center (EIDRC CC). The RTI-Duke CC will support the EIDRC-Net, which will comprise the EIDRCs, research sites, the CC, and NIAID by realizing the following aims: (1) enhance EIDRC coordination and collaboration by providing administrative, communications, logistical, and operational support; (2) amplify NIAID's capabilities and reach by coordinating and supporting a sustainable, scalable, and adaptable research infrastructure to optimize resources and knowledge sharing during inter-outbreak periods and to respond rapidly and effectively during outbreaks; (3) ensure quality and consistency of study data by using rigorous data and specimen management systems with built-in data quality assurance; (4) ensure quality of biospecimens, assays, and reagents through harmonization of standard operating procedures across EIDRC-Net sites and ongoing audit of cross-network procedures; and (5) develop the next generation of investigators and in-country scientists by establishing a pilot research program that identifies, funds, and mentors high-quality EIDRC applicants. By successfully accomplishing our five specific aims, the RTI-Duke team will shift the outbreak research response paradigm by establishing scalable systems, processes, and resources that not only provide the necessary infrastructure to facilitate EIDRC-Net performance and carry out CC core functions during inter-outbreak periods, but also can be enhanced and expanded to bolster CC research surge response activities during outbreaks. The EIDRC CC team will be co-led by multiple Principal Investigators Donald Brambilla, PhD (RTI), a biostatistician with advanced training in biology and an experienced CC leader, and Michael Anthony (Tony) Moody, MD (Duke), a pediatric infectious disease specialist and Chief Medical Officer of the Duke Human Vaccine Institute. Together they bring extensive scientific expertise, leadership, administrative experience, and international research expertise, including in geographic locations most relevant to the study of EIDs. This partnership also leverages the operational efficiency of RTI, a large nonprofit research organization with regional and project offices in over 75 countries, with the scientific rigor of Duke University, a premier university known for its cutting-edge medical research and home to a state-of-the-art, NIAID-funded Regional Biocontainment Laboratory.

项目总结/文摘