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SPORE for Translational Approaches to Brain Cancer

SPORE 用于脑癌转化方法

基本信息

批准号：
10626391
负责人：
MACIEJ S LESNIAK
金额：
$ 204.5万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-17 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626391
关键词：
Address Anabolism Autologous B-Lymphocytes Biogenesis Biological Markers Brain Brain Neoplasms CD8-Positive T-Lymphocytes Canis familiaris Catheters Cells Cellular Stress Characteristics Clinical Data Clinical Trials Complex DNA Damage Data Diagnosis Disease Enzymes Faculty Future Glioblastoma Glioma Goals Human IMPDH2 gene Immune response Immunity Immunotherapeutic agent Incidence Individual Inflammatory Infusion procedures Injections Interferon Type II Interferons Intracranial Neoplasms MGMT gene Malignant - descriptor Malignant Glioma Malignant Neoplasms Malignant neoplasm of brain Maximum Tolerated Dose Modeling Molecular Monitor Mus N-Acetylcysteinamide Nature Neoplasms Newly Diagnosed Operative Surgical Procedures Organ Outpatients Pathway interactions Patient Selection Patient-Focused Outcomes Patients Persons Phase Physiologic pulse Positron-Emission Tomography Prediction of Response to Therapy Predisposition Primary Brain Neoplasms Prognosis Public Health Purines Radiation Records Recurrence Research Research Personnel STING agonists Science System T-Lymphocyte TNFRSF5 gene Talents Testing Therapeutic Time Translations Treatment Efficacy Treatment outcome Tumor Antigens Vaccines anti-PD-L1 arm biomarker identification chemoradiation cohort conditionally replicative adenovirus cytotoxicity efficacy evaluation first-in-human human study improved improved outcome interdisciplinary approach manufacture member mouse model mycophenolate mofetil nerve stem cell novel novel therapeutics oncolytic adenovirus oncolytic virotherapy pre-clinical pre-clinical research prevent programs response response biomarker safety and feasibility sensor standard of care statistics success survivorship temozolomide therapeutic vaccine translational approach treatment optimization tumor

项目摘要

OVERALL: SUMMARY The overall objective of the Northwestern Brain Tumor SPORE is to improve outcomes for brain tumor patients. Of the various primary intracerebral neoplasms, glioblastoma (GBM) is the most common. GBM patients that receive standard-of-care treatment have a median survival of 20 months, and 5-year survival is extremely rare. Progress in developing better treatments for this lethal tumor has been disappointing. A major contributor to this lack of therapeutic improvement is the delicate nature of the organ in which this cancer occurs. There are significant limitations to how aggressively GBM patients can be treated surgically, and the efficacy of systemically administered therapies are often compromised due to limited access to the brain. To address the public health problem that is associated with glioblastoma, we have assembled a talented team of investigators with extensive backgrounds in brain tumor research and therapy. All members of this team have professional records indicating success in directing their own programs of research. Together, these faculty initiated group interactions in order to bring a team science approach to bear upon the study and treatment of GBM, and for which a multidisciplinary approach is needed for achieving meaningful progress.

总体:总结

项目成果

期刊论文数量（58）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma.

DOI：
10.1016/j.celrep.2023.112127
发表时间：
2023-02-28
期刊：
Cell reports
影响因子：
8.8
作者：
通讯作者：

Neuro-oncology at the American Society for Clinical Oncology 2022 Annual Meeting.

美国临床肿瘤学会 2022 年年会上的神经肿瘤学。

DOI：
10.1093/nop/npac071
发表时间：
2022
期刊：
Neuro-oncology practice
影响因子：
2.7
作者：
Lukas,RimasV;Chmura,StevenJ;Parney,IanF;Mammoser,Aaron;Smith,SonaliM;Li,Jing
通讯作者：
Li,Jing

Prohibitin Expression in Antigen-Presenting Cells: Implications for Inciting Trigger in CNS IgG4-Related Disease.

抗原呈递细胞中的抑制素表达：对中枢神经系统 IgG4 相关疾病的刺激触发的影响。

DOI：
10.29011/2574-7754.101607
发表时间：
2024
期刊：
Annals of case reports
影响因子：
0
作者：
Najem,Hinda;Arrieta,VictorA;Duffy,Joseph;Tripathi,Shashwat;Zannikou,Markella;Dhiantravan,Silpol;Miska,Jason;McCortney,Kathleen;Steffens,Alicia;Walshon,Jordain;LeeChang,Catalina;Dahdaleh,NaderS;Sonabend,AdamM;Smith,Zachary;H
通讯作者：
H

2018 Richards Medal Address: Rational Vaccinology: In Pursuit of the Perfect Vaccine.

2018 年理查兹奖章演讲：理性疫苗学：追求完美疫苗。