Project-001
项目-001
基本信息
- 批准号:10863455
- 负责人:
- 金额:$ 89.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-08 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:Accident and Emergency departmentAdherenceAdolescentAlgorithmsBehaviorBiometryBostonCaringCause of DeathCessation of lifeClinicalCollaborationsCommunitiesCountryDataData ReportingData ScienceData ScientistDecision MakingDedicationsDevelopmentEconomicsEducationElectronic Health RecordEmergency Department patientEmergency department visitEvaluationGeneral HospitalsGoalsGrantHealth PersonnelHealth systemHealthcare SystemsHospital AdministrationHospitalizationHospitalsInpatientsInterventionLearningMassachusettsMethodsPatient Self-ReportPatient riskPatientsPersonsPreventionProbabilityPsychiatryPsychologyPublic Health SchoolsRandomizedResearchResearch PersonnelResearch Project GrantsRiskSafetyScientific Advances and AccomplishmentsScientistSocietiesStructureSuicideSuicide attemptSuicide preventionTarget PopulationsTechnologyTestingTimeTrainingTranslatingUniversitiesVisionVisitWomanWorkacute careadaptive interventionalternative treatmentbiomedical informaticscareerclinical careclinical decision supportclinical decision-makingclinical practicecommunity buildingcommunity partnershipcomputer sciencedigitaldigital platformeffective therapyeffectiveness testinghealth care settingshealth datahigh riskimplementation effortsimprovedinnovationinnovative technologiesinpatient psychiatric settingsmachine learning algorithmmachine learning prediction algorithmmedical schoolsmemberminority childrennoveloutreachpopulation healthpractice settingpredictive modelingprogramsrandomized trialrisk predictionrisk stratificationsocial health determinantsstatisticssuicidal behaviorsuicidal risksuicide ratetherapy developmenttooltreatment optimizationtrial design
项目摘要
Suicide is one of the leading causes of death worldwide and the 10th leading cause of death in the US. A major
barrier to suicide prevention has been that the cutting-edge scientific advances that have occurred in the past
few decades have not yet been translated and implemented into clinical practice settings. We propose the
development of a practice-based Center for Suicide Research and Prevention (CSRP) that will support the
development, deployment, and evaluation of practice-ready and deployment-focused interventions aimed at
improving the identification and effective treatment of those at risk of suicide. This Center will be a collaborative
effort between researchers, clinicians, and stakeholders at Mass General Brigham (MGB) and Harvard
University. Our focus is on improving the identification and prevention of suicide-related behaviors (SRBs)
among patients presenting for treatment at emergency departments (EDs) and psychiatric inpatient units.
Decades of research have shown that 50% of people who die by suicide are seen in a healthcare setting within
one month before their death, 40% visit an ED the year before their death, and the suicide rate is highest in the
weeks immediately following discharge from a psychiatric inpatient hospitalization. Our first aim is to build and
maintain a cohesive and innovative transdisciplinary Center dedicated to advancing suicide prevention. This
will be accomplished via the work of our proposed Administrative Core and Methods Core. Our second aim
is to conduct four practice-focused research projects that target prediction and prevention of suicidal behaviors
in ED and inpatient settings. Our Signature Project (SIG) will implement a previously-develop machine learning
prediction algorithm based on electronic health record (EHR) and self-report data collected in the ED and
randomly assign the clinicians of 4,000 patients to receive (experimental condition) or not receive (control
condition) the predicted probability that their patient will make a suicide attempt after ED discharge. We will test
the impact of this intervention on the suicide attempt rate and clinician decision-making. The SIG also will
examine clinician acceptability and adherence, prediction model improvement, and the development of
treatment optimization rules regarding patients' likelihood of benefiting from hospitalization versus alternative
treatments. Our three Exploratory Projects (EXP): (EXP1) will use the SIG prediction model to identify ED
patients at risk of suicidal behavior and experimentally test the effectiveness of an enhanced outreach
intervention administered in collaboration with a community partner – Samaritans of Boston; (EXP2) will
implement and test EHR-based risk algorithms in two inpatient units with a special focus on the use of social
determinants of health to improve prediction among under-represented adolescents; and (EXP3) will test a
just-in-time adaptive intervention using an innovative micro-randomized trial design to connect at-risk patients
with care when needed most. The third aim of the Center is to support education, dissemination, and
implementation efforts that will have a significant and sustained effect on suicide prevention.
自杀是世界上最主要的死亡原因之一,在美国是第十大死亡原因。一个主要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MATTHEW K NOCK其他文献
MATTHEW K NOCK的其他文献
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{{ truncateString('MATTHEW K NOCK', 18)}}的其他基金
Intensive longitudinal study of suicidal behaviors and related health outcomes
对自杀行为和相关健康结果的深入纵向研究
- 批准号:
10629711 - 财政年份:2022
- 资助金额:
$ 89.09万 - 项目类别:
Intensive longitudinal study of suicidal behaviors and related health outcomes
对自杀行为和相关健康结果的深入纵向研究
- 批准号:
9981830 - 财政年份:2018
- 资助金额:
$ 89.09万 - 项目类别:
Intensive longitudinal study of suicidal behaviors and related health outcomes
对自杀行为和相关健康结果的深入纵向研究
- 批准号:
10224900 - 财政年份:2018
- 资助金额:
$ 89.09万 - 项目类别:
Multilevel Biomarkers for Suicidal Behavior: From Interpersonal Stress to Gene Expression in a Longitudinal Study of Adolescent Girls
自杀行为的多级生物标志物:青春期女孩纵向研究中从人际压力到基因表达
- 批准号:
9265135 - 财政年份:2015
- 资助金额:
$ 89.09万 - 项目类别:
Stress Responses as Prospective Predictors of Girls' Suicidality and Self-Injury
压力反应作为女孩自杀和自残的前瞻性预测因素
- 批准号:
8384855 - 财政年份:2009
- 资助金额:
$ 89.09万 - 项目类别:
Stress Responses as Prospective Predictors of Girls' Suicidality and Self-Injury
压力反应作为女孩自杀和自残的前瞻性预测因子
- 批准号:
7773013 - 财政年份:2009
- 资助金额:
$ 89.09万 - 项目类别:
Stress Responses as Prospective Predictors of Girls' Suicidality and Self-Injury
压力反应作为女孩自杀和自残的前瞻性预测因子
- 批准号:
7992405 - 财政年份:2009
- 资助金额:
$ 89.09万 - 项目类别:
Stress Responses as Prospective Predictors of Girls' Suicidality and Self-Injury
压力反应作为女孩自杀和自残的前瞻性预测因子
- 批准号:
8197059 - 财政年份:2009
- 资助金额:
$ 89.09万 - 项目类别:
Stress Responses as Prospective Predictors of Girls' Suicidality and Self-Injury
压力反应作为女孩自杀和自残的前瞻性预测因素
- 批准号:
8582568 - 财政年份:2009
- 资助金额:
$ 89.09万 - 项目类别:
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