1/2 The University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research

1/2 马萨诸塞大学波士顿分校 - 丹娜法伯/哈佛大学癌症中心 U54 癌症差异研究全面合作伙伴关系

• 批准号: 10870936
• 负责人: ADAN COLON-CARMONA
• 金额: $ 25.53万
• 依托单位: UNIVERSITY OF MASSACHUSETTS BOSTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-28 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10870936
• 关键词: Address; Advanced Malignant Neoplasm; Astronomy; Biological; Biological Sciences; Biology; Boston; Cancer Center; Communication; Communities; Community Developments; Couples; Coupling; Data; Data Science; Discipline; Education; Educational workshop; Genomics; Goals; Human; Immersion; Interdisciplinary Education; Investments; Knowledge; Malignant Neoplasms; Massachusetts; Mentors; Multilingualism; Parents; Program Development; Program Sustainability; Research; Resource Development; Science; Scientist; Students; Training; Training and Education; Translating; Translations; Underrepresented Minority; Universities; cancer health disparity; community building; design; education research; experience; genome sciences; genomic data; innovation; insight; institutional capacity; outreach; skills; training opportunity; undergraduate student

The goal of the parent University of Massachusetts Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) U54 CA156734 Partnership is to “pursue Partnership activities and research that will bridge the divides in cancer disparities science, research education, and outreach through innovative research, training, and practice.” This NOSI will extend these activities into the data science space by coupling the need to embrace new paradigms for computational research to equally urgent requirements to diversify and grow the computational genomics data sciences (CGDS) research workforce. This will be pursued through the accomplishment of 3 Specific Aims designed as a three-part educational and community development program: 1) Build a CGDS immersion workshop for undergraduate students of diverse backgrounds; 2) Develop complementary courses in CGDS, and 3) Aim 3: Build a data science community through mentored research and an inclusive “data club.” The scientific goal of this project is to resource the development and implementation of interdisciplinary education and training in biological data sciences that will enable the translation of data into biological insights to address cancer and cancer disparities. The community goal of this project is to offer many opportunities for training, education, and community building, including experiences specifically aimed at expanding participation of underrepresented minorities in genomics-focused biology and data science. The accomplishment of these goals will build a sustainable program to train diverse students as “multilingual” scientists with a broad range of skills and knowledge in both data and biological sciences that can effectively communicate and exchange ideas across disciplines to advance cancer- and cancer disparities-focused genomic sciences research.

母大学马萨诸塞州波士顿大学（UMass Boston）和达纳法伯/哈佛的目标是 癌症中心（DF/HCC）U 54 CA 156734合作伙伴关系是“追求合作伙伴关系的活动和研究， 将弥合癌症差异科学，研究教育和推广的鸿沟， 研究、培训和实践。”该NOSI将通过以下方式将这些活动扩展到数据科学领域 将接受新的计算研究范式的需要与同样紧迫的需求相结合 多样化和增长计算基因组学数据科学（CGDS）的研究队伍。这将是 通过实现三个具体目标来实现，这三个目标是一个由三部分组成的教育和 社区发展计划：1）为本科生建立CGDS沉浸式研讨会， 多样化的背景; 2）开发CGDS的补充课程，以及3）目标3：建立数据科学 社区通过指导研究和包容性的“数据俱乐部”。这个项目的科学目标是 为制定和实施生物数据方面的跨学科教育和培训提供资源 将数据转化为生物学见解以解决癌症和癌症的科学 差距。该项目的社区目标是提供许多培训、教育和 社区建设，包括专门旨在扩大 少数群体在以基因组学为重点的生物学和数据科学领域的代表性不足。完成这些 目标将建立一个可持续的计划，以培养不同的学生作为“多语言”的科学家， 一系列的技能和知识，在数据和生物科学，可以有效地沟通， 跨学科交流思想，以推进以癌症和癌症易感性为重点的基因组科学 research.

项目成果

CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation.

• DOI: 10.1038/s41598-018-21506-7
• 发表时间: 2018-02-22
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Patalano S;Rodríguez-Nieves J;Colaneri C;Cotellessa J;Almanza D;Zhilin-Roth A;Riley T;Macoska J
• 通讯作者: Macoska J

Stochastic Modeling of Gene Regulation by Noncoding Small RNAs in the Strong Interaction Limit.

强相互作用限制下非编码小 RNA 基因调控的随机建模。

• DOI: 10.1016/j.bpj.2018.04.044
• 发表时间: 2018
• 期刊: Biophysical journal
• 影响因子: 3.4
• 作者: Kumar,Niraj;Zarringhalam,Kourosh;Kulkarni,RahulV
• 通讯作者: Kulkarni,RahulV

Cyclin-dependent kinase 21 is a novel regulator of proliferation and meiosis in the male germline of zebrafish.

• DOI: 10.1530/rep-18-0386
• 发表时间: 2019-04
• 期刊: Reproduction
• 影响因子: 3.8
• 作者: Kaitlyn A. Webster;Katrin Henke;Delaney M Ingalls;Adeeba Nahrin;M. Harris;K. Siegfried

Stochastic gene expression conditioned on large deviations.

• DOI: 10.1088/1478-3975/aa6d89
• 发表时间: 2017-05-23
• 期刊: Physical biology
• 影响因子: 2
• 作者: Horowitz JM;Kulkarni RV
• 通讯作者: Kulkarni RV

Photodynamic Stromal Depletion Enhances Therapeutic Nanoparticle Delivery in 3D Pancreatic Ductal Adenocarcinoma Tumor Models.

光动力基质消耗增强 3D 胰腺导管腺癌肿瘤模型中的治疗性纳米颗粒递送。

• DOI: 10.1111/php.13663
• 发表时间: 2023
• 期刊: Photochemistry and photobiology
• 影响因子: 3.3
• 作者: Karimnia,Vida;Stanley,MElizabeth;Fitzgerald,ChristianT;Rizvi,Imran;Slack,FrankJ;Celli,JonathanP
• 通讯作者: Celli,JonathanP