BIOMECHANICS OF MALE/FEMALE HYPERTENSIVE/ATHEROSCLEROTIC SWINE AORTA

在我们的初步和以前的研究中，我们评估了有限的方面， 主动脉组织的机械和组织形态学特性 正常血压和高血压犬以及正常和 动脉粥样硬化/钙化的兔动脉。 在拟议的工作中，我们将把以前的工作扩展到广泛的领域， 研究其在体内和体外的力学性能和组织形态学 猪的胸腹部动脉瘤 动物模型会很大 猪（50-60公斤）。 猪是研究人的理想动物模型 心血管系统的健康和疾病。 我们将使用四组 猪（每组6只），第一组为对照组（血压正常， 非动脉粥样硬化）。 第二组将是高血压组 用戈德布拉特钳夹法使猪高血压 法 在第三组中，我们将产生饮食诱导的 动脉粥样硬化 第四组动物同时患有高血压 以及动脉粥样硬化。 每一组都有雄性和雌性 动物（6只）。 我们提出的研究的显着优势可以列出：1） 猪是人类心血管研究中最合适的动物模型， 2)大多数关于动物模型的研究使用雄性动物进行。 我们 在我们的研究中，将包括雄性和雌性猪，3）因为大多数 患有心血管疾病的患者是老年人 这两种疾病（高血压和动脉粥样硬化）都存在，我们的模型是 同时产生高血压和动脉粥样硬化的动物， 更适合研究人类心血管疾病，4）我们将生产 动脉粥样硬化的机械特性的重要数据， 高血压/动脉粥样硬化血管。 迫切需要这些数据， 建立有限元模型，模拟人体血管成形术 动脉病变 我们的长期目标是扩展这个有限元 在线临床系统分析，以成功预测结果 血管成形术，以减少或消除再狭窄。

In our preliminary and previous studies, we have evaluated limited aspects of mechanical and histomorphological properties of aortic tissues from normotensive and hypertensive dogs and from normal and atherosclerotic/calcified rabbit aortas. In the proposed work, we will extend our previous work to extensively study the in-vivo and in-vitro mechanical properties and histomorphology of porcine thoracic and abdominal aortas. The animal model would be large pigs (50-60 Kg). The pig is an ideal animal model to study the human cardiovascular system in health and disease. We will use four groups of pigs (6 each), the first group will be the control group (normotensive and non-atherosclerotic). The second group will be the hypertensive group where the pigs will be rendered hypertensive using the Goldblatt clamping technique. In the third group, we will produce diet-induced atherosclerosis. The fourth group of animals will have both hypertension and also atherosclerosis. Each group will have both male and female animals (6 each). The significant advantages of our proposed study can be listed as: 1) The pig is the most appropriate animal model in human cardiovascular studies, 2) most studies on animal models are conducted using male animals. We will include in our study, both male and female pigs, 3) since most patients having cardiovascular disease are the elderly and in most elderly both diseases (hypertension and atherosclerosis) are present, our model is producing animals with simultaneous hypertension and atherosclerosis is more appropriate to study human cardiovascular disease, 4) we will produce significant data on mechanical properties of atherosclerotic and hypertensive/atherosclerotic vessels. Such data is urgently needed to initiate finite element models to simulate the angioplasty of human diseased arteries. Our long-term goal is to extend this finite element analysis to an in line clinical system to successfully predict the results of angioplasty in order to reduce or eliminate re-stenosis.