BIOMECHANICS OF MALE/FEMALE HYPERTENSIVE/ATHEROSCLEROTIC SWINE AORTA

在我们的初步和以前的研究中，我们评估了有限的方面 大鼠主动脉组织的力学和组织形态特征 正常血压和高血压狗以及正常和 动脉粥样硬化/钙化兔动脉。 在拟议的工作中，我们将把以前的工作广泛地扩展到 材料的体内外力学性能和组织形态研究 猪的胸、腹主动脉。动物模型会很大 猪(50-60公斤)。猪是研究人类的理想动物模型 心血管系统与健康和疾病。我们将使用四组 猪(每组6头)，第一组为对照组(血压正常和 非动脉粥样硬化)。第二组将是高血压组 在那里，猪会被戈德布拉特钳制成高血压 技术。在第三组中，我们将产生饮食诱导 动脉硬化。第四组动物将同时患有高血压 还有动脉粥样硬化。每组将有男性和女性 动物(各6只)。 我们建议的研究的显著优点可列举如下：1) 猪是人类心血管研究中最合适的动物模型， 2)动物模型的研究大多采用雄性动物。我们 将在我们的研究中包括公猪和母猪，3)因为大多数 患有心血管疾病的患者是老年人，而且大多数老年人 这两种疾病(高血压和动脉粥样硬化)都存在，我们的模型是 制造出同时患有高血压和动脉粥样硬化的动物 更适合研究人类心血管疾病，4)我们将生产 动脉粥样硬化的力学性能的重要数据和 高血压/动脉粥样硬化血管。迫切需要这样的数据来 建立有限元模型模拟人体血管成形术 病变的动脉。我们的长期目标是扩展这种有限元 对一个成功预测结果的临床系统的分析 血管成形术，以减少或消除再狭窄。

In our preliminary and previous studies, we have evaluated limited aspects of mechanical and histomorphological properties of aortic tissues from normotensive and hypertensive dogs and from normal and atherosclerotic/calcified rabbit aortas. In the proposed work, we will extend our previous work to extensively study the in-vivo and in-vitro mechanical properties and histomorphology of porcine thoracic and abdominal aortas. The animal model would be large pigs (50-60 Kg). The pig is an ideal animal model to study the human cardiovascular system in health and disease. We will use four groups of pigs (6 each), the first group will be the control group (normotensive and non-atherosclerotic). The second group will be the hypertensive group where the pigs will be rendered hypertensive using the Goldblatt clamping technique. In the third group, we will produce diet-induced atherosclerosis. The fourth group of animals will have both hypertension and also atherosclerosis. Each group will have both male and female animals (6 each). The significant advantages of our proposed study can be listed as: 1) The pig is the most appropriate animal model in human cardiovascular studies, 2) most studies on animal models are conducted using male animals. We will include in our study, both male and female pigs, 3) since most patients having cardiovascular disease are the elderly and in most elderly both diseases (hypertension and atherosclerosis) are present, our model is producing animals with simultaneous hypertension and atherosclerosis is more appropriate to study human cardiovascular disease, 4) we will produce significant data on mechanical properties of atherosclerotic and hypertensive/atherosclerotic vessels. Such data is urgently needed to initiate finite element models to simulate the angioplasty of human diseased arteries. Our long-term goal is to extend this finite element analysis to an in line clinical system to successfully predict the results of angioplasty in order to reduce or eliminate re-stenosis.