Biology, Biomechanics and Atherosclerosis

生物学、生物力学和动脉粥样硬化

• 批准号: 6897323
• 负责人: William Robert Taylor
• 金额: $ 136.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6897323
• 关键词: apoptosis; atherosclerosis; atherosclerotic plaque; biomechanics; blood vessel prosthesis; cardiovascular function; clinical research; coronary disorder; electrocardiography; free radical oxygen; genetically modified animals; hemodynamics; human tissue; inflammation; laboratory mouse; magnetic resonance imaging; mechanical stress; method development; oscillatory blood flow; oxidative stress; phenotype; tissue /cell culture; vascular endothelium; vascular smooth muscle

DESCRIPTION (provided by the applicant): Cardiovascular disease remains the number one cause of death in the United States today. In addition to a plethora of genetic and environmental factors, the diet and lifestyle of Western populations continues to have a profound negative impact on the prevalence of atherosclerotic disease. Significant advances have been made in the management and treatment of the clinical sequalae of this disease process. However, many of these treatments are geared towards the management of catastrophic clinical events. Our understanding of the basic biology of the atherosclerotic lesion is still lacking in terms of a complete and fundamental understanding of the basic biology of the atherosclerotic lesion. The proposed Bioengineering Research Partnership (BRP) will be dedicated to establishing a consortium of investigators from Emory University School of Medicine and The Georgia Institute of Technology devoted to obtaining a greater understanding of the biology and engineering of this fundamental problem of great clinical importance. This BRP will expand upon established collaborations to incorporate expertise in basic vascular biology, imaging technologies, fluid mechanics, arterial wall mechanics, cardiac surgery, and interventional cardiology. We shall make use of explanted human hearts obtained from cardiac transplant recipients to provide a unique, model system to study living, human arteries with established atherosclerosis. The in vivo studies will be augmented by a series of cell culture studies designed to explicitly examine the effects of defined mechanical forces on inflammatory responses and apoptosis in a controlled setting. Finally, the impact of placement of clinically used coronary artery stents on the mechanical and subsequent biological responses of the arterial wall will be examined.

描述（由申请人提供）：心血管疾病