REFRACTIVE INDEX BASED FIBER OPTIC CHEMICAL SENSORS

基于折射率的光纤化学传感器

• 批准号: 2193700
• 负责人: Rudolf W. Seitz
• 金额: $ 10.62万
• 依托单位: UNIVERSITY OF NEW HAMPSHIRE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2193700
• 关键词: biomedical equipment development; biosensor device; fiber optics; lasers; molecular film; polymers; polystyrenes

DESCRIPTION: The Objective of the proposed research is to develop a new technology for fiber optic chemical sensors that can be applied to invasive biomedical measurements. The chemical sensing element is a thin (ca. 5 micrometers) film of a polymer coated onto the tip of an optical fiber. The polymer will be toughened, lightly crosslinked polystyrene chemically modified so that it swells and changes refractive index as a function of concentration of an analyte. Changes in refractive index will be measured as changes in the intensity of light reflected at the fiber/polymer and polymer/sample interfaces using a referenced, time-resolved measurement. The light source will be a laser diode pulsed at a frequency on the order of 10kHz. The proposed sensing technology is expected to be stable with respect to calibration since it involves a very thin layer of polymer and response times will be short. The proposed approach involves neither photoexcitation nor photodegradation as other fiber optic chemical sensors usually do and can be applied in the near infrared range in order to take advantage of technology developed for fiber optic communications. It will initially be developed with 100/140 micrometer core/cladding glass-on-glass optical fibers that can be miniaturized further for invasive measurements. A single inexpensive instrument is capable of several measurements as long as the length of fiber between the source and each measurement site differs. The polymer coating which is a toughened polystyrene formulation developed by the group can undergo repeated swelling and shrinking cycles without degrading mechanically and will be derivatized with an amine functional group to make a PH sensor, a dicarboxylate group to make a calcium sensor and boronic acid to make a sensor that responds to carbohydrates.

描述：拟议研究的目的是开发一种新的 光纤化学传感器技术，可应用于侵入性 生物医学测量 化学传感元件是薄的（约100毫米）。 5 微米）的聚合物膜涂覆到光纤的尖端上。 的 聚合物将增韧，轻度交联聚苯乙烯化学 改性以使其膨胀并改变折射率， 分析物的浓度。 将测量折射率的变化 随着在纤维/聚合物处反射的光的强度的变化， 聚合物/样品界面使用参考的时间分辨测量。 光源将是以大约1000 W的频率脉冲的激光二极管。 10 kHz。 所提出的传感技术预计将是稳定的， 关于校准，因为它涉及非常薄的聚合物层， 响应时间将很短。 拟议的办法既不涉及 与其它光纤化学传感器一样， 通常在近红外范围内使用， 光纤通信技术的优势。 它将 最初用100/140微米芯/包层玻璃对玻璃开发 可以进一步小型化以用于侵入式测量的光纤。 一台便宜的仪器能够进行多次测量， 因为光源和每个测量位置之间的光纤长度不同。 聚合物涂料是一种增韧的聚苯乙烯配方， 可以经历反复的膨胀和收缩循环， 机械降解，并将用胺官能衍生化， 一个二羧酸酯基团用于制备钙传感器， 和硼酸来制造一个对碳水化合物有反应的传感器。