EPIDEMIOLOGY OF ALZHEIMER DISEASE IN A TOTAL POPULATION

总人口中阿尔茨海默病的流行病学

• 批准号: 3121040
• 负责人: DAVID S KNOPMAN
• 金额: $ 41.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3121040
• 关键词: Alzheimer's disease; aluminum; brain disorder diagnosis; data collection methodology /evaluation; disease /disorder proneness /risk; environmental contamination; family genetics; gender difference; human morbidity; human old age (65+); human population study; human subject; interview; longitudinal human study; mass screening; mental health epidemiology; occupations; patient /disease registry; socioeconomics

An epidemiologic study of Alzheimer's disease (AD) based on a large population [that of the Saquenay-Lac-Saint-Jean (SLSJ) region of Quebec] with several unique and important features, including a computerized population database and one of the world's largest aluminum refineries, is proposed. The first phase of this study has 5 aims: (1) to validate a key informant ascertainment methodology for identifying cases of AD by means of a prevalence survey of 2 geographic regions in SLSJ; (2) to estimate age- and sex-specific prevalence rates of dementia and AD; (3) to follow prevalent cases in order to confirm diagnoses clinically and through autopsy; (4) to identify a fixed cohort of approximately 1,900 non-demented individuals that will be utilized in incidence, risk factor and survival studies; and (5) to perform a population-based case control study of AD focusing on family history od dementia, education and aluminum as risk factors. A 3-stage procedure will be utilized to identify cases. Stage 1 will provide initial identification of dementia suspects (by a network of key informants in year 1; by population screening in years 2 and 3). At stage 2, suspects will be assessed by specially-trained geriatricians and general practitioners to determine whether they meet DSM-IIIR criteria for dementia. At state 3, individuals considered to have dementia will receive a complete workup to determine the disease responsible for the dementia. Key informants will include both health professionals and lay persons. The prevalence survey will utilize a stratified random sample of 2,000 individuals over 64 identified from the socialized health care registry of Quebec. This sample will be screened, and those individuals who fail the screen will be evaluated in stages 2 and 3 for dementia. Non-demented subjects, who will comprise approximately 95% of the sample, will be re- evaluated and followed for development of dementia. Informants for cases of possible and probable AD and for 2 matched controls drawn from the non- demented population will participate in the case-control study. Other non- demented subjects will be administered the risk factor and family history questionnaires to study risk factors in relation to later development of AD.

阿尔茨海默病（AD）的流行病学研究基于一个大型的 人口[魁北克Saquenay-Lac-Saint-Jean（SLSJ）地区] 具有几个独特而重要的功能，包括计算机化的 人口数据库和世界上最大的铝精炼厂之一，是 提出了 本研究第一阶段有五个目的：（1）验证一个密钥 通过以下方式确定反倾销案件的线人确定方法 SLSJ中2个地理区域的患病率调查;（2）估计年龄- 痴呆和AD的性别特异患病率;（3）随访 流行病例，以确认临床诊断，并通过 （4）确定一个固定的队列，约有1，900名非痴呆症患者， 将在发病率、风险因素和生存率中使用的个体 研究;（5）进行基于人群的AD病例对照研究 关注痴呆症家族史、教育和铝作为风险因素 因素 将采用3阶段程序识别病例。 阶段1 将提供痴呆症嫌疑人的初步识别（通过一个网络， 第1年的关键信息提供者;第2年和第3年的人口筛查）。 在 第二阶段，怀疑人士将由受过专门训练的老人科医生进行评估， 全科医生，以确定他们是否符合DSM-IIIR标准， 痴呆 在状态3，被认为患有痴呆症的个人将接受 一个完整的检查来确定导致痴呆的疾病。 主要的举报人将包括保健专业人员和非专业人员。 的 流行率调查将使用2，000个分层随机样本 从社会化保健登记处确定的64岁以上的个人， 魁北克。 这个样本将被筛选，那些没有通过测试的人将被淘汰。 将在第2和第3阶段对痴呆症进行评估。 非痴呆 受试者将占样本的约95%，将重新 评估并跟踪痴呆症的发展。 案件举报人 可能和很可能的AD和2个来自非AD的匹配对照， 痴呆人群将参与病例对照研究。 其他非 将向痴呆受试者提供风险因素和家族史 调查问卷，以研究与以后发展有关的风险因素， AD.