Novel signalling pathways leading to the activation of glomerular parietal epithelial cells

导致肾小球壁上皮细胞激活的新信号通路

• 批准号: nhmrc : GNT1128582
• 负责人: Dr Victor Puelles
• 金额: $ 40.88万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-signalling-pathways-epithelial-cells/1347702
• 关键词: Novel; signalling; pathways; leading; activation

Chronic kidney disease (CKD) is a major health problem in Australia. CKD patients have very limited therapeutic options. The majority of diseases that lead to CKD are associated scarring of the renal filters. Parietal epithelial cells reside in these filters and play key roles in scarring development. However, the molecular mechanisms that lead to scarring in these renal filters remain unclear. This proposal aims to identify molecular pathways that may serve as future therapeutic targets.

慢性肾脏病(CKD)是澳大利亚的一个主要健康问题。CKD患者的治疗选择非常有限。大多数导致慢性肾脏病的疾病都与肾滤器的瘢痕形成有关。壁上皮细胞存在于这些滤器中，在瘢痕形成过程中起着关键作用。然而，导致这些肾滤器瘢痕形成的分子机制尚不清楚。这项提议旨在确定可能作为未来治疗靶点的分子途径。