RESPIRATOR TOLERANCE

呼吸机耐受性的决定因素似乎是 多因素的 本研究将采用人体样本组方法， 评估的综合影响，将 检查几种类型的呼吸器负荷的影响， 了解工人容忍的机制 使用呼吸器。 人类受试者小组将参加一项 系列讲话 结局指标将包括生理指标 变量（例如，呼吸计时、通气、呼吸工作）， 主观耐受性（通过视觉模拟量表测量）和工作 性能能力。 对负荷的心理生理敏感性（两者 电阻和压力偏置）也将被测量。 研究将 在实验室环境中，在规定的实地课程中进行 （在此期间，受试者可以自行定步调）和在工作场所。 呼吸器替代负载和实际呼吸器将 使用，并将使用几种类型的练习。 的 预测器之间的相互关系（例如， 呼吸机负荷，用力类型）和结果测量将 评估以确定呼吸器效应的机制， 为人类小组开发准确和合理简单的方法 来测试制冷机 实验设计允许复杂的 通过让每个受试者参与一系列研究进行分析 并通过随时间重复某些实验条件。 次级项目将处理其他具体问题。 的影响 生理压力偏置（如许多SCBA发生的）， 主观、工作表现和肺容量测量将 测试. 一群自我认同的工人， 不容忍的破坏者将参与。 制冷剂的使用 在模拟的“紧急使用”情况下， 与常规使用相比。

The determinants of respirator tolerance appear to be multifactorial. This study will utilize a human panel method for the assessment of the integrated effects of respirators and will examine the effects of several types of respirator loads to gain understanding of the mechanisms by which workers tolerate respirator use. Panels of human subjects will participate in a series of studies. Outcome measures will include physiologic variables (e.g., respiratory timing, ventilation, ventilatory work), subjective tolerance (measured by visual analog scales), and work performance ability. Psychophysiologic sensitivity to loads (both resistive and pressure bias) will be measured as well. Studies will be performed in a laboratory setting, in a prescribed field course (during which the subject may self pace), and at worksites. Respirator surrogate loads and actual respirators will be employed, and several types of exercise will be employed. The inter-relationships between and among the predictor (e.g., respirator load, exertion type) and outcome measures will be assessed to define mechanisms of respirator effects and to develop accurate and reasonably simple means for human panels to test respirators. The experimental design permits complex analyses by having each subject participate in a series of studies and by repeating certain experimental conditions over time. Subprojects will address additional specific problems. The effects of pressure biasing (as occurs with many SCBA's) upon physiologic, subjective, work performance, and lung volume measures will be tested. A group of self-identified workers who are particularly intolerant of respirators will participate. The use of respirators in simulated "emergency use" situations will be assessed in comparison to more routine use.