SMOKING AND DIETARY ANTECEDENTS OF PARKINSON DISEASE

帕金森病的吸烟和饮食因素

• 批准号: 3417280
• 负责人: David M. Morens
• 金额: $ 14.91万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1994-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3417280
• 关键词: MAO inhibitors; Parkinson's disease; aging; antioxidants; ascorbate; carbon monoxide poisoning; copper; dietary constituent; disease /disorder prevention /control; ethanol; free radicals; human subject; interview; medical records; mercury poisoning; nervous system disorder epidemiology; neuropsychological tests; occupational hazard; postmortem; retinoids; selenium; tobacco abuse; tocopherols

This epidemiologic study examines the possible relationship between smoking, diet, and other health habits, and the risk of developing Parkinson disease. By using nested case-control methods, and cohort methods, we will evaluate all living and dead subjects in the 8,000-man Honolulu Heart Program cohort. We will link health status, as determined by the ongoing (1991 - 1993) rescreening of subjects, to histories of diet, smoking, and occupational/personal exposures documented at the program's inception in 1965. The information from this study should provide clues to the causes of, and the pathogenesis of Parkinson disease, including information bearing on the theory that Parkinson disease is an exaggerated or atypical form of the normal aging process in which free radical damage to neural cells results from various metabolic, toxic, genetic, or dietary causes. The study may also suggest avenues for further research and interventions to prevent Parkinson disease, or to delay its progression, by dietary and lifestyle measures.

这项流行病学研究探讨了 吸烟、饮食和其他健康习惯，以及发展 帕金森病。 采用巢式病例对照方法， 方法，我们将评估8,000人中所有活着和死去的受试者， 檀香山心脏项目队列。 我们将链接健康状态， 由正在进行的（1991 - 1993）受试者再筛选确定， 饮食、吸烟和职业/个人暴露史 在1965年该计划开始时就有记录。 的信息 这项研究应该提供线索的原因和发病机制， 帕金森病，包括信息轴承的理论， 帕金森病是正常衰老的一种夸张或非典型形式， 自由基损伤神经细胞的过程， 各种代谢、毒性、遗传或饮食原因。 这项研究可能 还提出了进一步研究和干预的途径，以防止 帕金森病，或延缓其进展，通过饮食和生活方式 措施