SMOKING AND DIETARY ANTECEDENTS OF PARKINSON DISEASE

帕金森病的吸烟和饮食因素

• 批准号: 3417281
• 负责人: David M. Morens
• 金额: $ 13万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1994-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3417281
• 关键词: MAO inhibitors; Parkinson's disease; aging; antioxidants; ascorbate; carbon monoxide poisoning; copper; dietary constituent; disease /disorder prevention /control; ethanol; free radical oxygen; human subject; interview; medical records; mercury poisoning; nervous system disorder epidemiology; neuropsychological tests; nutrition related tag; occupational hazard; postmortem; retinoids; selenium; tobacco abuse; tocopherols

This epidemiologic study examines the possible relationship between smoking, diet, and other health habits, and the risk of developing Parkinson disease. By using nested case-control methods, and cohort methods, we will evaluate all living and dead subjects in the 8,000-man Honolulu Heart Program cohort. We will link health status, as determined by the ongoing (1991 - 1993) rescreening of subjects, to histories of diet, smoking, and occupational/personal exposures documented at the program's inception in 1965. The information from this study should provide clues to the causes of, and the pathogenesis of Parkinson disease, including information bearing on the theory that Parkinson disease is an exaggerated or atypical form of the normal aging process in which free radical damage to neural cells results from various metabolic, toxic, genetic, or dietary causes. The study may also suggest avenues for further research and interventions to prevent Parkinson disease, or to delay its progression, by dietary and lifestyle measures.

这项流行病学研究考察了两种疾病之间可能的关系 吸烟、饮食和其他健康习惯，以及发展的风险 帕金森氏症。采用嵌套式病例对照方法和队列研究 方法，我们将评估8000人中所有活着和死亡的受试者 火奴鲁鲁心脏计划队列。我们将链接健康状态，因为 由正在进行的(1991-1993年)对受试者的重新筛选确定为 饮食、吸烟和职业/个人接触史 在1965年该计划开始时被记录在案。信息来自 这项研究应提供线索的原因和发病机制。 帕金森病，包括与以下理论有关的信息 帕金森病是一种夸张的或非典型的正常衰老 自由基致神经细胞损伤的过程 代谢、毒性、遗传或饮食方面的各种原因。这项研究可能 还提出了进一步研究和干预的途径，以防止 帕金森病，或通过饮食和生活方式延缓病情进展 措施。