INFECTION ENHANCEMENT--AN EXPERIMENTAL MODEL OF SIDS

感染增强——小岛屿发展中国家的实验模型

• 批准号: 3310959
• 负责人: David M. Morens
• 金额: $ 14.42万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3310959
• 关键词: B lymphocyte; Pneumovirus; T lymphocyte; antiviral agents; antiviral antibody; cell mediated cytotoxicity; cellular immunity; communicable disease diagnosis; complement pathway; dengue; dengue virus; disease /disorder model; disseminated intravascular coagulation; fluorescence microscopy; host organism interaction; human tissue; immunization; immunoglobulin G; immunopathology; immunoregulation; kidney cell; lysozyme; microorganism immunology; monocyte; newborn animals; phagocytosis; plaque assay; postmortem; radiotracer; respiratory virus; sudden infant death syndrome; tissue /cell culture; virulence; virus antigen; virus infection mechanism; virus replication

This study deals with the possibility that enhanced infection results in enhanced disease. Specifically, it proposes to investigate the mediation of viral infection by non-neutralizing antibody. The infection of mononuclear phagocytes by dengue virus is the prototype for this phenomenon. The ultimate research goal is to identify effector mechanisms in dengue disease and to evaluate analogous immunopathological mechanisms and effectors which might be responsible for triggering SIDS. Because dengue shock syndrome correlates with the state of immune elimination of virus infected cells, this phase of our research will focus on the immune response to dengue, using the monkey model. In view of their possible role in SIDS, respiratory syncytial and parainfluenza viruses will be studied for immunologically enhanced infection in leukocytes, in vitro.

This study deals with the possibility that enhanced infection results in 疾病增强。 Specifically, it proposes to investigate the mediation of 非中和抗体引起的病毒感染。 单核细胞感染 phagocytes by dengue virus is the prototype for this phenomenon. The ultimate research goal is to identify effector mechanisms in dengue disease and to evaluate analogous immunopathological mechanisms and effectors which 可能是触发 SIDS 的原因。 因为登革热休克综合症 correlates with the state of immune elimination of virus infected cells, this phase of our research will focus on the immune response to dengue, using the 猴子模型。 In view of their possible role in SIDS, respiratory syncytial and parainfluenza viruses will be studied for immunologically enhanced infection in 白细胞，体外。