INFECTION ENHANCEMENT--AN EXPERIMENTAL MODEL OF SIDS

感染增强——小岛屿发展中国家的实验模型

• 批准号: 3310958
• 负责人: David M. Morens
• 金额: $ 1.23万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3310958
• 关键词: B lymphocyte; Pneumovirus; T lymphocyte; antiviral agents; antiviral antibody; cell mediated cytotoxicity; cellular immunity; communicable disease diagnosis; complement pathway; dengue; dengue virus; disease /disorder model; disseminated intravascular coagulation; fluorescence microscopy; host organism interaction; human tissue; immunization; immunoglobulin G; immunopathology; immunoregulation; kidney cell; lysozyme; microorganism immunology; monocyte; newborn animals; phagocytosis; plaque assay; postmortem; radiotracer; respiratory virus; sudden infant death syndrome; tissue /cell culture; virulence; virus antigen; virus infection mechanism; virus replication

This study deals with the possibility that enhanced infection results in enhanced disease. Specifically, it proposes to investigate the mediation of viral infection by non-neutralizing antibody. The infection of mononuclear phagocytes by dengue virus is the prototype for this phenomenon. The ultimate research goal is to identify effector mechanisms in dengue disease and to evaluate analogous immunopathological mechanisms and effectors which might be responsible for triggering SIDS. Because dengue shock syndrome correlates with the state of immune elimination of virus infected cells, this phase of our research will focus on the immune response to dengue, using the monkey model. In view of their possible role in SIDS, respiratory syncytial and parainfluenza viruses will be studied for immunologically enhanced infection in leukocytes, in vitro.

这项研究探讨了感染增强导致 增强的疾病 具体而言，它建议调查调解， 非中和抗体引起的病毒感染。 单核细胞感染 登革病毒的吞噬细胞是这种现象的原型。 最终的研究目标是确定登革热疾病的效应机制 并评估类似的免疫病理学机制和效应物， 可能是引发婴儿猝死综合症的原因 因为登革热休克综合症 与病毒感染细胞的免疫清除状态相关， 我们的研究阶段将集中在登革热的免疫反应，使用 猴子模型 鉴于它们在SIDS中的可能作用，呼吸道合胞体和 将研究副流感病毒的免疫增强感染， 白细胞，体外。

项目成果

Antiviral effects if ribavirin and 6-mercapto-9-tetrahydro-2-furylpurine against dengue viruses in vitro.

利巴韦林和 6-巯基-9-四氢-2-呋喃基嘌呤在体外对登革热病毒具有抗病毒作用。

• DOI: 10.1016/0166-3542(82)90027-4
• 发表时间: 1982
• 期刊: Antiviral research
• 影响因子: 7.6
• 作者: Koff,WC;ElmJr,JL;Halstead,SB
• 通讯作者: Halstead,SB

Heterogeneity of infection enhancement of dengue 2 strains by monoclonal antibodies.

单克隆抗体增强登革热 2 株感染的异质性。

• 发表时间: 1984
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Halstead,SB;Venkateshan,CN;Gentry,MK;Larsen,LK
• 通讯作者: Larsen,LK

Propagation of dengue viruses in murine cell cultures.

登革热病毒在小鼠细胞培养物中的繁殖。

• DOI: 10.4269/ajtmh.1981.30.461
• 发表时间: 1981
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Koff,W;ElmJr,JL;Halstead,SB
• 通讯作者: Halstead,SB

Study of the distribution of antibody-dependent enhancement determinants on dengue 2 isolates using dengue 2-derived monoclonal antibodies.

使用登革热 2 衍生的单克隆抗体研究登革热 2 分离株上抗体依赖性增强决定簇的分布。

• DOI: 10.1002/jmv.1890220207
• 发表时间: 1987
• 期刊: Journal of medical virology
• 影响因子: 12.7
• 作者: Morens,DM;Larsen,LK;Halstead,SB
• 通讯作者: Halstead,SB

Dengue shock syndrome in an American traveler with primary dengue 3 infection.

一名原发性登革热 3 感染的美国旅行者出现登革热休克综合征。

• DOI: 10.4269/ajtmh.1987.36.424
• 发表时间: 1987
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Morens,DM;Sather,GE;Gubler,DJ;Rammohan,M;Woodall,JP
• 通讯作者: Woodall,JP