NITROUS OXIDE CONSCIOUS SEDATION--ANXIOYSIS

一氧化二氮清醒镇静——焦虑

• 批准号: 3425483
• 负责人: RAYMOND MARK QUOCK
• 金额: $ 2.22万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1992-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425483
• 关键词: analgesia; anesthesia; chlordiazepoxide; drug metabolism; laboratory rat; morphine; nitrous oxide; opiate alkaloid; sedative /hypnotic

Nitrous oxide is widely used for production of conscious sedation in clinical dentistry. This clinical application of low concentrations of nitrous oxide specifically for reduction of anxiety is unique to dentistry. Nitrous oxide also possesses prominent analgesic and weak anesthetic properties that have been widely studied. However, its anxiolytic effect has not been well investigate and the underlying mechanism(s) of action remain(s) unknown. Recent research suggests that an apparent anxiolytic effect of nitrous oxide is demonstrable in the mouse staircase test, a relatively new anxiety paradigm. This application proposes pilot experiments to determine the feasibility of future basic research into the mechanism of anxiolytic effect of nitrous oxide. The goals of this proposed research are to study 2 established and validated experimental paradigms (the social interaction test and the defensive burying test in rats): (1) a concentration-dependent anxiolytic effect of nitrous oxide and comparison with chlordiazepoxide (an anxiolytic standard) and morphine (an analgesic standard); and (2) sensitivity of the effects of these 3 drug challenges (nitrous oxide, chlordiazepoxide and morphine) to interaction with opioid and benzodiazepine receptor blockers. Carried to a successful conclusion, this proposed research will make possible further and more sophisticated investigations for characterization of the anxiolytic effect of nitrous oxide and elucidation of its mechanism(s) of action. The long term objective of this research is to continue a systematic analysis of the pharmacological properties of nitrous oxide. The findings of such research should advance our understanding of the pharmacology of nitrous oxide and contribute to more efficacious or judicious clinical use of nitrous oxide in dentistry and medicine.

一氧化二氮被广泛用于生产清醒镇静

项目成果

Benzodiazepine receptor mediation of behavioral effects of nitrous oxide in mice.

苯二氮卓受体介导一氧化二氮对小鼠行为的影响。

• DOI: 10.1007/bf02245153
• 发表时间: 1992
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Quock,RM;Emmanouil,DE;Vaughn,LK;Pruhs,RJ
• 通讯作者: Pruhs,RJ

Nitrous oxide induces an anxiolytic-like effect in the conditioned defensive burying paradigm, which can be reversed with a benzodiazepine receptor blocker.

一氧化二氮在条件性防御性掩埋范式中会产生类似抗焦虑的作用，这种作用可以用苯二氮卓受体阻滞剂逆转。

• DOI: 10.1007/bf02245699
• 发表时间: 1993
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Czech,DA;Quock,RM
• 通讯作者: Quock,RM

Benzodiazepine receptor-mediated behavioral effects of nitrous oxide in the rat social interaction test.

大鼠社交互动测试中一氧化二氮受体介导的苯二氮卓受体介导的行为效应。

• DOI: 10.1016/0091-3057(93)90335-q
• 发表时间: 1993
• 期刊: Pharmacology, biochemistry, and behavior
• 作者: Quock,RM;Wetzel,PJ;Maillefer,RH;Hodges,BL;Curtis,BA;Czech,DA
• 通讯作者: Czech,DA