SYNAPTIC TRANSMISSION IN TRIGEMINAL SUBNUCLEUS CAUDALIS

三叉神经尾亚核的突触传递

• 批准号: 3425522
• 负责人: LI-YEN M HUANG
• 金额: $ 1.98万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425522
• 关键词: action potentials; afferent nerve; analgesia; laboratory rat; medulla oblongata; neural information processing; neural transmission; oral facial pain; pain; synapses; thalamus

This research project is concerned with the functional role of the trigeminal (V) spinal subnucleus caudalis in the processing of pain information. Our long term goal is to determine how pain information is transmitted and regulated in the central nervous system. The specific goal of this proposal is to examine primary afferent-evoked synaptic responses and the action potential in trigeminothalamic neurons in thin medulla slices. The ionic currents and single channel activities of trigeminothalamic neurons will be measured using patch clamp recording techniques. The information obtained will enhance our understanding of the role that trigeminal system has in processing pain-related messages and will facilitate the designing of the therapy for the treatment of orofacial pain.

这项研究项目涉及到的功能作用 三叉神经脊束核尾侧亚核在痛觉加工中的作用 信息。我们的长期目标是确定疼痛信息是如何 在中枢神经系统中传递和调节。具体目标 这项建议的目的是检查初级传入诱发的突触反应 薄髓内三叉神经丘脑神经元的动作电位 切片。 三叉神经丘脑的离子电流和单通道活动 神经元将使用膜片钳记录技术进行测量。这个 所获得的信息将加深我们对 三叉神经系统在处理与疼痛相关的信息和意志 促进口腔颌面外科治疗方案的设计 疼痛。