A DICHOTOMOUS SAMPLER FOR TRIG AEROSOL AND VAPOR

异氰酸酯是一种重要的商业化学品， 聚氨酯和某些杀虫剂的生产。此外，本发明还提供了一种方法， 各种形式的异氰酸酯化合物在热处理过程中释放出来， 聚氨酯材料的分解。记录了异氰酸酯 致敏物，引起职业性哮喘，过敏性肺炎， 以及肺功能每年加速下降。所述化合物 其特征在于高度的化学反应性，并且一些具有 较高成形表面和相对较低的蒸气压 温度这些性质导致某些异氰酸酯 在大气中分解成气相和颗粒相。的 化合物的物理状态会影响其 在呼吸道中的沉积/吸附，以及指示 适当的取样技术和工程控制方法。这 该项目需要开发一个二分取样器， 反应性异氰酸酯基团（TRIG）蒸气和颗粒， 用于收集气相的环形扩散器， 通过经处理的过滤器收集冷凝相。 分析 将通过HPLC采集TRIG。 三种常见的衍生剂 （甲氨基-甲基蒽，甲氧基苯基-哌嗪，色胺）将 使用一系列的方法对TRIG的可靠测定进行评估， 十三种异氰酸酯模型化合物。显示最多的试剂 将使用对模型异氰酸酯的一致分析响应 在二分采样器中。采样器将在以下方面进行优化： 其临界长度和取样流量，以及其性能 将使用以下试验气氛对特性进行全面评估： 气溶胶和气相异氰酸酯，并与撞击器和过滤器进行比较 抽样方法采样器将用于表征TRIG， 两个聚氨酯泡沫塑料厂和两个异氰酸酯厂的工作场所空气 制造工厂。这项工作将导致一个更彻底的 了解TRIG在大气中的行为，并将提供 一个强大的工具，为未来的研究的潜在差异， 生物活性及汽相和凝相行为 异氰酸酯。

The isocyanates are an important class of commercial chemicals used in the production of polyurethanes and certain pesticides. In addition, various forms of isocyanate compounds are emitted during the thermal decomposition of urethane materials. Isocyanates are documented sensitizers, causing occupational asthma, hypersensitivity pneumonitis, and accelerated annual decline in lung function. The compounds are characterized by a high degree of chemical reactivity, and some have a high for surfaces and relatively low vapor pressures at ambient temperatures. These properties result in a tendency for some isocyanates to partition into gaseous and particulate phases in the atmosphere. The physical state of the compound will affect its site of deposition/adsorption in the respiratory tract, as well as dictate the appropriate sampling techniques and engineering control methods. This project entails the development of a dichotomous sampler for total reactive isocyanate group (TRIG) vapor and particulate consisting of an annular diffusional denuder for collection of the vapor phase, backed up by a treated filter for collection of the condensed phase. Analysis of collected TRIG will be by HPLC. Three common derivatizing agents (methyamino-methylanthracene, methoxyphenyl-piperazine, tryptamine) will be evaluated for reliable determination of TRIG using a series of thirteen model isocyanate compounds. The reagent exhibiting the most consistent analytical response to the model isocyanates will be utilized in the dichotomous sampler. The sampler will be optimized in terms of its critical length and sampling flow rate, and its performance characteristics will be thoroughly evaluated using test atmospheres of aerosol and vapor phase isocyanate, and compared to impinger and filter sampling methods. The sampler will be used to characterize TRIG in workplace atmosphere at two polyurethane foam plants and two isocyanate manufacturing plants. This work will result in a more thorough understanding of the behavior of TRIG in the atmosphere, and will offer a powerful tool for future studies of the potential differences in the biological activities and behaviors of vapor and condensed phase isocyanate.