Pediatric Inflammatory Diseases of the Respiratory Tract: Asthma

小儿呼吸道炎症疾病：哮喘

• 批准号: 7732632
• 负责人: Dean D Metcalfe
• 金额: $ 15.33万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732632
• 关键词: Adult; Allergic; Anti-Inflammatory Agents; Anti-inflammatory; Asthma; Bronchoconstriction; Child; Childhood; Childhood Asthma; Chronic; Clinical; Data; Data Collection; Detection; Diagnostic; Disease; Disease Outcome; Europe; Exhalation; Functional disorder; Future; Glucocorticoids; Goals; Guidelines; High Prevalence; Hypersensitivity; Immunologics; Inflammation; Inflammatory; Institutes; Intervention; Invasive; Longitudinal Studies; Lung Inflammation; Lung diseases; Maintenance; Measurement; Measures; Mediator of activation protein; Methods; Morbidity - disease rate; Nitric Oxide; Outcome; Patients; Pattern; Persons; Pharmacotherapy; Pneumonia; Recurrence; Respiratory Tract Diseases; Sampling; Severities; Severity of illness; Spirometry; Stratification; Surveys; Symptoms; Techniques; airway inflammation; asthmatic patient; concept; cytokine; information gathering; interest; prevent; pulmonary function

The onset of asthma is often during childhood; and when the child is atopic, the child is more likely to continue to have asthma as an adult. Diseases such as asthma have a higher prevalence in childhood; and management that alters the morbidity of allergic diseases in children may impact disease outcomes in future years. This study examines techniques for the detection of inflammation in children with respiratory diseases due to allergy or immunologic dysfunction. Emphasis is on non-invasive methods. We will use information gathered to determine if there are inflammatory markers that may be diagnostic or representative of disease severity, and thus useful in management. Preliminary data supports the concept of ongoing airway inflammation in asymptomatic children with asthma. It also supports the existing use of nitric oxide as a marker of airway inflammation that may or may not correlate with bronchoconstriction as demonstrated by spiromertry. Furthermore, an elevated expired nitric oxide seen in association with airway inflammation may be associated with a decrease in airway pH, previously documented during an asthma exacerbation. A similar pattern was not demonstrated in healthy matched controls. Of interest, a small representative sample of exhaled breath condensate was analyzed for several inflammatory cytokines and the results are pending. We are completing the data collection in this longitudinal study of non-invasive measurements of airway inflammation in children with asthma and healthy-matched controls.

哮喘通常在儿童时期发病；当孩子有特应性时，孩子成年后更有可能继续患有哮喘。 哮喘等疾病在儿童时期的患病率较高；改变儿童过敏性疾病发病率的管理可能会影响未来几年的疾病结果。 本研究探讨了因过敏或免疫功能障碍而患有呼吸道疾病的儿童炎症的检测技术。重点是非侵入性方法。我们将利用收集到的信息来确定是否存在可以诊断或代表疾病严重程度的炎症标记物，从而有助于管理。 初步数据支持无症状哮喘儿童持续气道炎症的概念。它还支持现有的一氧化氮作为气道炎症标志物的使用，该标志物可能与肺量测定所证明的支气管收缩相关，也可能不相关。此外，与气道炎症相关的呼气一氧化氮升高可能与气道 pH 值降低有关，这在哮喘恶化期间已有记录。在健康匹配的对照中没有表现出类似的模式。 有趣的是，对呼出气冷凝物的少量代表性样本进行了几种炎症细胞因子的分析，结果正在等待中。 我们正在完成这项纵向研究的数据收集，该研究对哮喘儿童和健康匹配对照的气道炎症进行无创测量。