Pediatric Inflammatory Diseases of the Respiratory Tract: Asthma

小儿呼吸道炎症疾病：哮喘

• 批准号: 7732632
• 负责人: Dean D Metcalfe
• 金额: $ 15.33万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732632
• 关键词: Adult; Allergic; Anti-Inflammatory Agents; Anti-inflammatory; Asthma; Bronchoconstriction; Child; Childhood; Childhood Asthma; Chronic; Clinical; Data; Data Collection; Detection; Diagnostic; Disease; Disease Outcome; Europe; Exhalation; Functional disorder; Future; Glucocorticoids; Goals; Guidelines; High Prevalence; Hypersensitivity; Immunologics; Inflammation; Inflammatory; Institutes; Intervention; Invasive; Longitudinal Studies; Lung Inflammation; Lung diseases; Maintenance; Measurement; Measures; Mediator of activation protein; Methods; Morbidity - disease rate; Nitric Oxide; Outcome; Patients; Pattern; Persons; Pharmacotherapy; Pneumonia; Recurrence; Respiratory Tract Diseases; Sampling; Severities; Severity of illness; Spirometry; Stratification; Surveys; Symptoms; Techniques; airway inflammation; asthmatic patient; concept; cytokine; information gathering; interest; prevent; pulmonary function

The onset of asthma is often during childhood; and when the child is atopic, the child is more likely to continue to have asthma as an adult. Diseases such as asthma have a higher prevalence in childhood; and management that alters the morbidity of allergic diseases in children may impact disease outcomes in future years. This study examines techniques for the detection of inflammation in children with respiratory diseases due to allergy or immunologic dysfunction. Emphasis is on non-invasive methods. We will use information gathered to determine if there are inflammatory markers that may be diagnostic or representative of disease severity, and thus useful in management. Preliminary data supports the concept of ongoing airway inflammation in asymptomatic children with asthma. It also supports the existing use of nitric oxide as a marker of airway inflammation that may or may not correlate with bronchoconstriction as demonstrated by spiromertry. Furthermore, an elevated expired nitric oxide seen in association with airway inflammation may be associated with a decrease in airway pH, previously documented during an asthma exacerbation. A similar pattern was not demonstrated in healthy matched controls. Of interest, a small representative sample of exhaled breath condensate was analyzed for several inflammatory cytokines and the results are pending. We are completing the data collection in this longitudinal study of non-invasive measurements of airway inflammation in children with asthma and healthy-matched controls.

哮喘的发作通常是在童年时期。当孩子原住了时，孩子更有可能继续成年。 哮喘等疾病在童年时期患病率更高；和改变儿童过敏性疾病发病率的管理可能会影响未来几年的疾病结果。 这项研究检查了由于过敏或免疫功能障碍而导致呼吸道疾病儿童炎症检测的技术。重点是非侵入性方法。我们将使用收集的信息来确定是否有炎症标记可能是诊断或代表疾病严重程度的，因此在管理中有用。 初步数据支持哮喘无症状儿童正在进行的气道炎症的概念。它还支持现有的一氧化氮用作气道炎症的标记，这种炎症可能与支气管收缩相关，如螺旋形炎症所证明。此外，与气道炎症相关的升高的一氧化氮可能与气道pH值的降低有关，这是在哮喘加重过程中以前记录的。在健康匹配的对照中未证明类似的模式。 值得注意的是，分析了几种炎症细胞因子的呼出呼吸凝结物的少量代表性样本，结果正在等待。 我们正在完成这项对哮喘和健康匹配对照儿童气道炎症无创测量的纵向研究中的数据收集。