REGULATION OF CYTOKINE GENE EXPRESSION IN MAST CELLS

肥大细胞中细胞因子基因表达的调节

基本信息

项目摘要

It is known that rodent mast cells respond to nerve growth factor (NGF). We have now shown that both the human mast cell line HMC-1 and cultured human mast cells similarly respond to NGF as evidenced by induction of the immediate early gene c-fos through the trkA tyrosine receptor which is phosphorylated on tyrosine residues following NGF exposure. HMC-1 and human mast cells were also found to express NGF mRNA and conditioned media from HMC-1 cells stimulated neurite outgrowth, an effect blocked by anti-NGF. Similarly, we identified the receptor for alpha-melanocyte stimulating hormone (alpha-MSH), MC-1, on murine mast cells. Treatment of mast cells with alpha-MSH increased cAMP levels and down-modulated expression of mRNA for IL-1beta, TNF-alpha, and lymphotactin in activated mast cells. In an animal model of asthma, we have characterized the resident cells responsible for immediate-early IL-4 production following antigen challenge.
众所周知,啮齿动物的肥大细胞对神经有反应

项目成果

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Dean D Metcalfe其他文献

Plasma IL-6 correlates with disease category and with hematological parameters in patients with mastocytosis
  • DOI:
    10.1016/s0091-6749(02)81601-3
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Knut Brockow;Cem Akin;Mary M Huber;Dean D Metcalfe
  • 通讯作者:
    Dean D Metcalfe
Comparison of FceRI and FcγRI-dependent signaling pathways in human mast cells
  • DOI:
    10.1016/s0091-6749(02)82259-x
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Christine Tkaczyk;Yoshimishi Okayama;Dean D Metcalfe;Alasdair M Gilfillan
  • 通讯作者:
    Alasdair M Gilfillan
Serum tryptase levels combined with flow cytometric analysis of bone marrow aspirate mast cells differentiate systemic mastocytosis from idiopathic syndromes
  • DOI:
    10.1016/s0091-6749(02)81675-x
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Cem Akin;Arnold S Kirshenbaum;Dean D Metcalfe
  • 通讯作者:
    Dean D Metcalfe
Direct determination of allergen specific T cell cytokine responses during immunotherapy
  • DOI:
    10.1016/s0091-6749(02)82225-4
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    L Brigida Cayosa Hunter;Varatda Plainetr;Barbara Foster;Mary M Huber;Dean D Metcalfe;Calman Prussin
  • 通讯作者:
    Calman Prussin

Dean D Metcalfe的其他文献

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{{ truncateString('Dean D Metcalfe', 18)}}的其他基金

Developmental Immunotherapeutics for Allergic Diseases and Asthma
过敏性疾病和哮喘的发育免疫治疗
  • 批准号:
    6099081
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Fc Receptors in Mast Cell Signaling and Function
肥大细胞信号传导和功能中的 Fc 受体
  • 批准号:
    6431716
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Pathogenesis of Physical Urticaria Syndromes
物理性荨麻疹综合征的发病机制
  • 批准号:
    8946474
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
The Pathogenesis, Diagnosis, And Treatment Of Systemic Mast Cell Disorders
系统性肥大细胞疾病的发病机制、诊断和治疗
  • 批准号:
    9354692
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
The Pathogenesis, Diagnosis, And Treatment Of Systemic Mast Cell Disorders
系统性肥大细胞疾病的发病机制、诊断和治疗
  • 批准号:
    10014014
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Pathogenesis and Treatment of Anaphylaxis
过敏反应的发病机制和治疗
  • 批准号:
    10014172
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
The Pathogenesis, Diagnosis, And Treatment of Systemic Mast Cell Disorders
系统性肥大细胞疾病的发病机制、诊断和治疗
  • 批准号:
    10272016
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Molecular Biology Of Mast Cell Growth And Differentiation
肥大细胞生长和分化的分子生物学
  • 批准号:
    7732464
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
The Pathogenesis, Diagnosis, And Treatment Of Systemic Mast Cell Disorders
系统性肥大细胞疾病的发病机制、诊断和治疗
  • 批准号:
    7964210
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Activation of Mast Cells in Disease States: Pharmacological Modification
疾病状态下肥大细胞的激活:药理学修饰
  • 批准号:
    7964545
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

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