REGULATION OF CYTOKINE GENE EXPRESSION IN MAST CELLS
肥大细胞中细胞因子基因表达的调节
基本信息
- 批准号:6098983
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
It is known that rodent mast cells respond to nerve
growth factor (NGF). We have now shown that both the human
mast cell line HMC-1 and cultured human mast cells similarly
respond to NGF as evidenced by induction of the immediate early
gene c-fos through the trkA tyrosine receptor which is
phosphorylated on tyrosine residues following NGF exposure.
HMC-1 and human mast cells were also found to express NGF
mRNA and conditioned media from HMC-1 cells stimulated neurite
outgrowth, an effect blocked by anti-NGF. Similarly, we identified
the receptor for alpha-melanocyte stimulating hormone
(alpha-MSH), MC-1, on murine mast cells. Treatment of mast cells
with alpha-MSH increased cAMP levels and down-modulated
expression of mRNA for IL-1beta, TNF-alpha, and lymphotactin in
activated mast cells. In an animal model of asthma, we have
characterized the resident cells responsible for immediate-early IL-4
production following antigen challenge.
众所周知,啮齿类动物的肥大细胞会对神经元产生反应,
生长因子(NGF)。我们现在已经证明,
肥大细胞系HMC-1和培养的人肥大细胞类似地
对NGF的反应,如通过诱导即刻早期
基因c-fos通过trkA酪氨酸受体,
在NGF暴露后酪氨酸残基上磷酸化。
HMC-1和人肥大细胞也表达NGF
HMC-1细胞的mRNA和条件培养基刺激神经突
生长,抗神经生长因子阻断的效果。同样,我们发现
α-黑素细胞刺激激素受体
(α-MSH),MC-1,对鼠肥大细胞的作用。肥大细胞的治疗
与α-MSH增加cAMP水平和下调
IL-1 β、TNF-α和巨噬细胞趋化因子mRNA表达
激活的肥大细胞在哮喘的动物模型中,
表征了负责立即早期IL-4的驻留细胞,
抗原攻击后的生产。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dean D Metcalfe其他文献
Plasma IL-6 correlates with disease category and with hematological parameters in patients with mastocytosis
- DOI:
10.1016/s0091-6749(02)81601-3 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Knut Brockow;Cem Akin;Mary M Huber;Dean D Metcalfe - 通讯作者:
Dean D Metcalfe
Comparison of FceRI and FcγRI-dependent signaling pathways in human mast cells
- DOI:
10.1016/s0091-6749(02)82259-x - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Christine Tkaczyk;Yoshimishi Okayama;Dean D Metcalfe;Alasdair M Gilfillan - 通讯作者:
Alasdair M Gilfillan
Serum tryptase levels combined with flow cytometric analysis of bone marrow aspirate mast cells differentiate systemic mastocytosis from idiopathic syndromes
- DOI:
10.1016/s0091-6749(02)81675-x - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
Cem Akin;Arnold S Kirshenbaum;Dean D Metcalfe - 通讯作者:
Dean D Metcalfe
Direct determination of allergen specific T cell cytokine responses during immunotherapy
- DOI:
10.1016/s0091-6749(02)82225-4 - 发表时间:
2002-01-01 - 期刊:
- 影响因子:
- 作者:
L Brigida Cayosa Hunter;Varatda Plainetr;Barbara Foster;Mary M Huber;Dean D Metcalfe;Calman Prussin - 通讯作者:
Calman Prussin
Dean D Metcalfe的其他文献
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{{ truncateString('Dean D Metcalfe', 18)}}的其他基金
Developmental Immunotherapeutics for Allergic Diseases and Asthma
过敏性疾病和哮喘的发育免疫治疗
- 批准号:
6099081 - 财政年份:
- 资助金额:
-- - 项目类别:
The Pathogenesis, Diagnosis, And Treatment Of Systemic Mast Cell Disorders
系统性肥大细胞疾病的发病机制、诊断和治疗
- 批准号:
7964210 - 财政年份:
- 资助金额:
-- - 项目类别:
Activation of Mast Cells in Disease States: Pharmacological Modification
疾病状态下肥大细胞的激活:药理学修饰
- 批准号:
7964545 - 财政年份:
- 资助金额:
-- - 项目类别:
Clinical and Immunological Evaluation of Children with Allergic Disease
儿童过敏性疾病的临床和免疫学评估
- 批准号:
7964522 - 财政年份:
- 资助金额:
-- - 项目类别:
Pediatric Inflammatory Diseases of the Respiratory Tract: Asthma
小儿呼吸道炎症疾病:哮喘
- 批准号:
7732632 - 财政年份:
- 资助金额:
-- - 项目类别:
Molecular Biology Of Mast Cell Growth And Differentiation
肥大细胞生长和分化的分子生物学
- 批准号:
7732464 - 财政年份:
- 资助金额:
-- - 项目类别:
The Pathogenesis, Diagnosis, And Treatment Of Systemic Mast Cell Disorders
系统性肥大细胞疾病的发病机制、诊断和治疗
- 批准号:
10014014 - 财政年份:
- 资助金额:
-- - 项目类别:
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