Digital Technology to Support Adherence to Hypertension Medications for Older Adults with Mild Cognitive Impairment
数字技术支持患有轻度认知障碍的老年人坚持高血压药物治疗
基本信息
- 批准号:10618618
- 负责人:
- 金额:$ 86.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-04 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationActivities of Daily LivingAddressAdherenceAdoptionAdultAgeAndroidAntihypertensive AgentsAttentionBlood PressureCOVID-19 pandemicCOVID-19 pandemic effectsCaringCerebrovascular DisordersChronicCognitionCognitiveCollaborationsCommunitiesCompensationCompetenceControl GroupsDementiaDeteriorationDevelopmentDoseDrug PrescriptionsEducationEducational InterventionElderlyEnsureEvaluationFailureFamilyFriendsFutureHealthHealth PersonnelHealth ProfessionalHealth systemHealthcareHeart failureHumanHypertensionImpaired cognitionImpairmentIndividualInterventionInterviewLearning SkillMedication ManagementMemoryMonitorMyocardial InfarctionOutcomePersonsPharmaceutical PreparationsPopulationPopulations at RiskQuality of lifeRandomized, Controlled TrialsReminder SystemsRiskSelf DeterminationSelf ManagementSelf MedicationStandardizationStrokeStructureSupport SystemSystemTechnologyTestingTimeVulnerable Populationscardiovascular risk factorcognitive abilitycognitive functioncognitive skillcomorbiditydementia riskdesigndigitaldigital healthdigital interventiondigital technologydigital treatmentefficacy evaluationefficacy studyexperiencegroup interventionheuristicshigh riskimprovedlonely individualsmHealthmHealth self-managementmedication compliancemedication nonadherencemembermild cognitive impairmentpreservationprocedural memoryprospective memoryrandomized, clinical trialsrate of changeremote monitoringsupport toolstheoriestoolusabilityuser centered designweb portal
项目摘要
Abstract
Mild cognitive impairment (MCI) is characterized by mild impairment in one or more cognitive functions and is
associated with an increased risk for failure to take prescribed medications. Hypertension is prevalent among
persons with MCI (PwMCI) and nonadherence to medications increases the risk of accelerated cognitive
decline through cerebrovascular disease. Adherence is often only 46% or lower among PwMCI. Further, the
COVID-19 pandemic has resulted in the isolation of these individuals from care partners (friends, family, and
healthcare workers) who assist with medication management, uncovering the urgent need for developing self-
management tools. We have previously developed a theory-based mobile health (mHealth) system called
Medication Education, Decision Support, Reminding, and Monitoring (MEDSReM) to support adherence in
cognitively normal older adults, which can be adapted for PwMCI. No existing studies have evaluated the
benefits of mHealth self-management tools to support hypertension medication adherence for PwMCI. In order
for such digital interventions to be beneficial, they have to be carefully designed/adapted to meet the unique
capabilities and limitations of PwMCI. User-centered technology has been shown to promote independence
and autonomy by compensating for lost cognitive skills. In this proposal, we are poised to address the unique
needs for digital technology use in this at-risk population of PwMCI based on user-centered design to guide the
development of Medication Education, Decision Support, Reminding, and Monitoring-Memory (MEDSReM-M)
system, conduct iterative usability testing to optimize the system for PwMCI, and examine the efficacy to
support hypertension medication adherence. In Aim 1, facilitators and barriers for use of MEDSReM will be
identified by interviewing PwMCI and their care partners, after they are shown the self-management system to
guide the development of MEDSReM-M. Then using heuristic evaluations and cognitive walkthroughs, and
through iterative usability testing with PwMCI, we will test, redesign, and optimize the system for PwMCI. In
Aim 2 we will conduct a randomized controlled trial involving 100 PwMCI to test the effects of MEDSReM-M
relative to an standardized educational control group on outcomes including adherence to hypertension
medications, blood pressure, self-determination (competence and autonomy), and technology acceptance. We
will then test predictors of the rate of change in medication adherence over 3 months to inform future large-
scale deployment. Taking a human factors approach to identify needs and requirements for technological
support to take medications as intended, and iterative testing for the usability of MEDSReM-M among PwMCI
with a consequent RCT, will result in a digital health intervention system that has the potential to reduce
cognitive decline associated with cardiovascular risks, save healthcare dollars, and promote autonomy and
quality of life in this vulnerable population.
摘要
轻度认知障碍(MCI)的特征在于一种或多种认知功能的轻度障碍,
与不服用处方药的风险增加有关。高血压在以下人群中普遍存在:
MCI(PwMCI)患者和不依从药物治疗的患者会增加加速认知功能障碍的风险。
因脑血管疾病而衰退。PwMCI患者的依从性通常仅为46%或更低。此夕h
COVID-19大流行导致这些人与护理伙伴(朋友、家人和
医疗保健工作者)谁协助药物管理,发现迫切需要发展自我,
管理工具。我们以前开发了一个基于理论的移动的健康(mHealth)系统,称为
药物教育、决策支持、提醒和监测(MEDSReM),以支持
认知正常的老年人,这可以适应PwMCI。目前尚无研究评价
移动健康自我管理工具的好处,以支持PwMCI的高血压药物依从性。为了
为了使这种数字干预措施有益,必须仔细设计/调整,以满足独特的
PwMCI的能力和局限性。以用户为中心的技术已被证明可以促进独立性
和自主性来弥补失去的认知能力。在这份提案中,我们准备解决独特的
基于以用户为中心的设计,在PwMCI高危人群中使用数字技术的需求,
开发药物教育、决策支持、提醒和引导记忆(MEDSReM-M)
系统,进行迭代可用性测试,以优化系统的PwMCI,并检查有效性,
支持高血压药物治疗依从性。在目标1中,使用MEDSReM的促进因素和障碍将
通过采访PwMCI及其护理伙伴确定,在向他们展示自我管理系统后,
指导MEDSReM-M的开发。然后使用启发式评估和认知步行,
通过与PwMCI的迭代可用性测试,我们将为PwMCI测试、重新设计和优化系统。在
目的2:我们将进行一项涉及100例PwMCI的随机对照试验,以测试MEDSReM-M的效果
相对于标准化教育对照组的结局,包括对高血压的依从性
药物,血压,自我决定(能力和自主权)和技术接受。我们
然后,将测试3个月内药物依从性变化率的预测因素,以告知未来的大型
规模部署。采取人为因素办法,确定技术需求和要求,
支持按预期服药,并在PwMCI中对MEDSReM-M的可用性进行迭代测试
与随后的随机对照试验,将导致数字健康干预系统,有可能减少
与心血管风险相关的认知能力下降,节省医疗费用,促进自主性,
这一弱势群体的生活质量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KATHLEEN C INSEL其他文献
KATHLEEN C INSEL的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KATHLEEN C INSEL', 18)}}的其他基金
Digital Technology to Support Adherence to Hypertension Medications for Older Adults with Mild Cognitive Impairment
数字技术支持患有轻度认知障碍的老年人坚持高血压药物治疗
- 批准号:
10363162 - 财政年份:2022
- 资助金额:
$ 86.65万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
7839534 - 财政年份:2009
- 资助金额:
$ 86.65万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
7695022 - 财政年份:2008
- 资助金额:
$ 86.65万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
7877972 - 财政年份:2008
- 资助金额:
$ 86.65万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
8092862 - 财政年份:2008
- 资助金额:
$ 86.65万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
7579519 - 财政年份:2008
- 资助金额:
$ 86.65万 - 项目类别:
Biological Age and Capacity for Self-Management: Implications for Nursing
生物年龄和自我管理能力:对护理的影响
- 批准号:
7256356 - 财政年份:2006
- 资助金额:
$ 86.65万 - 项目类别:
Biological Age and Capacity for Self-Management: Implications for Nursing
生物年龄和自我管理能力:对护理的影响
- 批准号:
7134805 - 财政年份:2006
- 资助金额:
$ 86.65万 - 项目类别:
相似海外基金
Determining 4-Dimensional Foot Loading Profiles of Healthy Adults across Activities of Daily Living
确定健康成年人日常生活活动的 4 维足部负荷曲线
- 批准号:
2473795 - 财政年份:2024
- 资助金额:
$ 86.65万 - 项目类别:
Studentship
Developing a trunk function assessment for hemiplegics. -For improving activities of daily living-
开发偏瘫患者的躯干功能评估。
- 批准号:
23K10540 - 财政年份:2023
- 资助金额:
$ 86.65万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Relation with the activities of daily living and the subjective values among people with social withdrawal
社交退缩者日常生活活动与主观价值观的关系
- 批准号:
23K16596 - 财政年份:2023
- 资助金额:
$ 86.65万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
CRII: RI: Understanding Activities of Daily Living in Indoor Scenarios
CRII:RI:了解室内场景中的日常生活活动
- 批准号:
2245652 - 财政年份:2023
- 资助金额:
$ 86.65万 - 项目类别:
Standard Grant
Sources of vulnerability among those using homecare despite having no limitations in Activities of Daily Living. An intersectionality analysis
尽管日常生活活动没有限制,但使用家庭护理的人的脆弱性来源。
- 批准号:
499112 - 财政年份:2023
- 资助金额:
$ 86.65万 - 项目类别:
Operating Grants
Association between Nursing Care and Prognosis and Activities of Daily Living in Acute Stroke patients by using Big Data.
利用大数据研究急性脑卒中患者的护理与预后和日常生活活动的关系。
- 批准号:
23K16412 - 财政年份:2023
- 资助金额:
$ 86.65万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Effects of a model of nurses-occupational therapists collaborative practice on activities of daily living in elderly patients
护士-职业治疗师合作实践模式对老年患者日常生活活动的影响
- 批准号:
22K17540 - 财政年份:2022
- 资助金额:
$ 86.65万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Synergizing home health rehabilitation therapy to optimize patients’ activities of daily living
协同家庭健康康复治疗,优化患者的日常生活活动
- 批准号:
10429480 - 财政年份:2022
- 资助金额:
$ 86.65万 - 项目类别:
Assessing a Novel Virtual Environment that Primes Individuals Living with AD/ADRD to Accomplish Activities of Daily Living.
评估一种新颖的虚拟环境,该环境可以帮助 AD/ADRD 患者完成日常生活活动。
- 批准号:
10668160 - 财政年份:2022
- 资助金额:
$ 86.65万 - 项目类别:
Synergizing home health rehabilitation therapy to optimize patients’ activities of daily living
协同家庭健康康复治疗,优化患者的日常生活活动
- 批准号:
10621820 - 财政年份:2022
- 资助金额:
$ 86.65万 - 项目类别: