Biological Age and Capacity for Self-Management: Implications for Nursing

生物年龄和自我管理能力：对护理的影响

基本信息

批准号：
7256356
负责人：
KATHLEEN C INSEL
金额：
$ 7.25万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-07 至 2008-12-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The purpose of this investigation is to examine the association between biological age and executive function/working memory among individuals with hypertension. Prior investigations suggest executive function and working memory capacity are important cognitive processes essential for self-management. In addition to the importance of these processes to understanding self-management, it has been shown that executive function and working memory decline with age. This would seem to implicate age as a risk factor for failure to self-manage, for example, medications. This, however, has not been demonstrated. Several investigations suggest that chronological age is a poor predictor of self-management capacity and indeed that older adults may be better on some everyday tasks than young counterparts. While chronological age is not implicated in self-management, it is possible that biological age is a predictor of executive function/ working memory capacity in clinical populations accounting for differences in self-management. This descriptive correlational study uses telomere length as a marker for biological age and examines the association of telomere length to executive function/working memory capacity among individuals > 50 years of age self-managing one prescribed medication for hypertension. The study also identifies oxidative stress as a likely mechanism for accelerated biological aging in persons with hypertension. Oxidative stress will be quantified and associated with disease severity, biological age and executive function/working memory capacity. The study also seeks to provide converging evidence for the association between executive function/working memory capacity and medication adherence, an established self-management activity.

描述（由申请人提供）：这项调查的目的是检查高血压患者之间生物年龄与执行功能/工作记忆之间的关联。先前的调查表明，执行功能和工作记忆能力是自我管理必不可少的重要认知过程。除了这些过程对理解自我管理的重要性外，还表明执行功能和工作记忆随着年龄的增长而下降。这似乎将年龄视为无法自我管理的危险因素，例如药物。但是，这尚未得到证明。几项调查表明，按时间顺序的年龄是自我管理能力的差预测指标，实际上，老年人在某些日常任务上可能比年轻的年轻人更好。尽管按年代年龄与自我管理无关，但生物年龄可能是临床人群中执行功能/工作记忆能力的预测指标，从而考虑了自我管理的差异。这项描述性相关研究使用端粒长度作为生物年龄的标记，并研究了端粒长度与执行功能/工作记忆能力的关联> 50岁以上的人自我管理一种用于高血压的处方药。该研究还确定了氧化应激是高血压患者加速生物衰老的可能机制。氧化应激将被量化并与疾病的严重程度，生物年龄和执行功能/工作记忆能力有关。该研究还旨在为执行功能/工作记忆能力和药物依从性（已建立的自我管理活动）之间的关联提供融合的证据。