Biological Age and Capacity for Self-Management: Implications for Nursing

生物年龄和自我管理能力:对护理的影响

基本信息

  • 批准号:
    7256356
  • 负责人:
  • 金额:
    $ 7.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-07-07 至 2008-12-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The purpose of this investigation is to examine the association between biological age and executive function/working memory among individuals with hypertension. Prior investigations suggest executive function and working memory capacity are important cognitive processes essential for self-management. In addition to the importance of these processes to understanding self-management, it has been shown that executive function and working memory decline with age. This would seem to implicate age as a risk factor for failure to self-manage, for example, medications. This, however, has not been demonstrated. Several investigations suggest that chronological age is a poor predictor of self-management capacity and indeed that older adults may be better on some everyday tasks than young counterparts. While chronological age is not implicated in self-management, it is possible that biological age is a predictor of executive function/ working memory capacity in clinical populations accounting for differences in self-management. This descriptive correlational study uses telomere length as a marker for biological age and examines the association of telomere length to executive function/working memory capacity among individuals > 50 years of age self-managing one prescribed medication for hypertension. The study also identifies oxidative stress as a likely mechanism for accelerated biological aging in persons with hypertension. Oxidative stress will be quantified and associated with disease severity, biological age and executive function/working memory capacity. The study also seeks to provide converging evidence for the association between executive function/working memory capacity and medication adherence, an established self-management activity.
描述(由申请人提供):本研究的目的是检查高血压患者的生物学年龄与执行功能/工作记忆之间的关联。先前的研究表明,执行功能和工作记忆容量是自我管理所必需的重要认知过程。除了这些过程对理解自我管理的重要性之外,已经表明执行功能和工作记忆随着年龄的增长而下降。这似乎暗示年龄是无法自我管理的风险因素,例如药物。然而,这一点尚未得到证明。几项调查表明,实际年龄是自我管理能力的一个很差的预测因素,事实上,老年人在一些日常任务上可能比年轻人做得更好。虽然实际年龄不涉及自我管理,但生物学年龄可能是临床人群中自我管理差异的执行功能/工作记忆能力的预测因子。这项描述性相关性研究使用端粒长度作为生物学年龄的标志,并检查了端粒长度与> 50岁的个体自我管理一种处方药物治疗高血压的执行功能/工作记忆能力的相关性。该研究还确定氧化应激是高血压患者加速生物衰老的可能机制。将量化氧化应激,并将其与疾病严重程度、生物学年龄和执行功能/工作记忆能力相关联。该研究还试图为执行功能/工作记忆能力与药物依从性(一种既定的自我管理活动)之间的关联提供汇聚证据。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
White matter hyperintensities and medication adherence.
  • DOI:
    10.1177/1099800408322216
  • 发表时间:
    2008-10
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Insel KC;Reminger SL;Hsiao CP
  • 通讯作者:
    Hsiao CP
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KATHLEEN C INSEL其他文献

KATHLEEN C INSEL的其他文献

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{{ truncateString('KATHLEEN C INSEL', 18)}}的其他基金

Digital Technology to Support Adherence to Hypertension Medications for Older Adults with Mild Cognitive Impairment
数字技术支持患有轻度认知障碍的老年人坚持高血压药物治疗
  • 批准号:
    10363162
  • 财政年份:
    2022
  • 资助金额:
    $ 7.25万
  • 项目类别:
Digital Technology to Support Adherence to Hypertension Medications for Older Adults with Mild Cognitive Impairment
数字技术支持患有轻度认知障碍的老年人坚持高血压药物治疗
  • 批准号:
    10618618
  • 财政年份:
    2022
  • 资助金额:
    $ 7.25万
  • 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
  • 批准号:
    7839534
  • 财政年份:
    2009
  • 资助金额:
    $ 7.25万
  • 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
  • 批准号:
    7695022
  • 财政年份:
    2008
  • 资助金额:
    $ 7.25万
  • 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
  • 批准号:
    7877972
  • 财政年份:
    2008
  • 资助金额:
    $ 7.25万
  • 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
  • 批准号:
    8092862
  • 财政年份:
    2008
  • 资助金额:
    $ 7.25万
  • 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
  • 批准号:
    7579519
  • 财政年份:
    2008
  • 资助金额:
    $ 7.25万
  • 项目类别:
Biological Age and Capacity for Self-Management: Implications for Nursing
生物年龄和自我管理能力:对护理的影响
  • 批准号:
    7134805
  • 财政年份:
    2006
  • 资助金额:
    $ 7.25万
  • 项目类别:
Cognitive Aging and Everyday Remembering
认知老化和日常记忆
  • 批准号:
    6401105
  • 财政年份:
    2001
  • 资助金额:
    $ 7.25万
  • 项目类别:

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