Biological Age and Capacity for Self-Management: Implications for Nursing
生物年龄和自我管理能力:对护理的影响
基本信息
- 批准号:7256356
- 负责人:
- 金额:$ 7.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-07-07 至 2008-12-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingAcuteAddressAdherenceAgeAge-YearsBiological AgingBiological MarkersCellsChronicClinicalCognitiveCognitive agingConditionDiscipline of NursingElderlyFailureHypertensionImpaired healthIndividualInvestigationLengthLiteratureLongevityMeasuresMethodsMonitorOxidative StressPerformancePersonsPharmaceutical PreparationsPopulationProcessPurposeRateRisk FactorsSelf CareSelf ManagementSeveritiesSeverity of illnessShort-Term MemorySourceTelomere ShorteningThinkingVascular SystemVascular remodelingWorkage relatedbasecognitive functiondistractionexecutive functionmedication compliancemiddle agetelomereyoung adult
项目摘要
DESCRIPTION (provided by applicant): The purpose of this investigation is to examine the association between biological age and executive function/working memory among individuals with hypertension. Prior investigations suggest executive function and working memory capacity are important cognitive processes essential for self-management. In addition to the importance of these processes to understanding self-management, it has been shown that executive function and working memory decline with age. This would seem to implicate age as a risk factor for failure to self-manage, for example, medications. This, however, has not been demonstrated. Several investigations suggest that chronological age is a poor predictor of self-management capacity and indeed that older adults may be better on some everyday tasks than young counterparts. While chronological age is not implicated in self-management, it is possible that biological age is a predictor of executive function/ working memory capacity in clinical populations accounting for differences in self-management. This descriptive correlational study uses telomere length as a marker for biological age and examines the association of telomere length to executive function/working memory capacity among individuals > 50 years of age self-managing one prescribed medication for hypertension. The study also identifies oxidative stress as a likely mechanism for accelerated biological aging in persons with hypertension. Oxidative stress will be quantified and associated with disease severity, biological age and executive function/working memory capacity. The study also seeks to provide converging evidence for the association between executive function/working memory capacity and medication adherence, an established self-management activity.
描述(由申请人提供):本研究的目的是检查高血压患者的生物学年龄与执行功能/工作记忆之间的关联。先前的研究表明,执行功能和工作记忆容量是自我管理所必需的重要认知过程。除了这些过程对理解自我管理的重要性之外,已经表明执行功能和工作记忆随着年龄的增长而下降。这似乎暗示年龄是无法自我管理的风险因素,例如药物。然而,这一点尚未得到证明。几项调查表明,实际年龄是自我管理能力的一个很差的预测因素,事实上,老年人在一些日常任务上可能比年轻人做得更好。虽然实际年龄不涉及自我管理,但生物学年龄可能是临床人群中自我管理差异的执行功能/工作记忆能力的预测因子。这项描述性相关性研究使用端粒长度作为生物学年龄的标志,并检查了端粒长度与> 50岁的个体自我管理一种处方药物治疗高血压的执行功能/工作记忆能力的相关性。该研究还确定氧化应激是高血压患者加速生物衰老的可能机制。将量化氧化应激,并将其与疾病严重程度、生物学年龄和执行功能/工作记忆能力相关联。该研究还试图为执行功能/工作记忆能力与药物依从性(一种既定的自我管理活动)之间的关联提供汇聚证据。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
White matter hyperintensities and medication adherence.
- DOI:10.1177/1099800408322216
- 发表时间:2008-10
- 期刊:
- 影响因子:2.5
- 作者:Insel KC;Reminger SL;Hsiao CP
- 通讯作者:Hsiao CP
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KATHLEEN C INSEL其他文献
KATHLEEN C INSEL的其他文献
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{{ truncateString('KATHLEEN C INSEL', 18)}}的其他基金
Digital Technology to Support Adherence to Hypertension Medications for Older Adults with Mild Cognitive Impairment
数字技术支持患有轻度认知障碍的老年人坚持高血压药物治疗
- 批准号:
10363162 - 财政年份:2022
- 资助金额:
$ 7.25万 - 项目类别:
Digital Technology to Support Adherence to Hypertension Medications for Older Adults with Mild Cognitive Impairment
数字技术支持患有轻度认知障碍的老年人坚持高血压药物治疗
- 批准号:
10618618 - 财政年份:2022
- 资助金额:
$ 7.25万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
7839534 - 财政年份:2009
- 资助金额:
$ 7.25万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
7695022 - 财政年份:2008
- 资助金额:
$ 7.25万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
7877972 - 财政年份:2008
- 资助金额:
$ 7.25万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
8092862 - 财政年份:2008
- 资助金额:
$ 7.25万 - 项目类别:
Multifaceted Prospective Memory Intervention to Improve Medication Adherence
多方面的前瞻性记忆干预可提高药物依从性
- 批准号:
7579519 - 财政年份:2008
- 资助金额:
$ 7.25万 - 项目类别:
Biological Age and Capacity for Self-Management: Implications for Nursing
生物年龄和自我管理能力:对护理的影响
- 批准号:
7134805 - 财政年份:2006
- 资助金额:
$ 7.25万 - 项目类别:
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